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Beat Thürlimann Selected Research

letrozole (Femara)

12/2015ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer.
9/2015Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial.
6/2015CYP19A1 polymorphisms and clinical outcomes in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial.
11/2012Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial.
3/2012CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.
11/2011Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
3/2011Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
2/2011Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trial.
1/2011Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
10/2010Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial.
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Beat Thürlimann Research Topics

Disease

45Breast Neoplasms (Breast Cancer)
12/2015 - 09/2003
16Neoplasms (Cancer)
12/2015 - 09/2003
4Neoplasm Metastasis (Metastasis)
10/2014 - 05/2007
3Hypercholesterolemia
12/2007 - 12/2005
2Osteoporosis
10/2014 - 04/2014
2Bone Fractures (Bone Fracture)
04/2008 - 02/2007
2Hemorrhage
02/2007 - 12/2005
2Hot Flashes
02/2007 - 01/2007
1Lobular Carcinoma
09/2015
1Ductal Carcinoma
09/2015
1Obesity
11/2012
1Pneumonia (Pneumonitis)
09/2012
1Disease Progression
01/2011
1Interstitial Lung Diseases (Interstitial Lung Disease)
01/2010
1Hypertension (High Blood Pressure)
12/2007
1Arthralgia (Joint Pain)
02/2007
1Heart Failure
02/2007
1Ischemia
02/2007
1Amenorrhea
01/2007
1Thromboembolism
12/2005
1Endometrial Neoplasms (Endometrial Cancer)
12/2005
1Noninfiltrating Intraductal Carcinoma (DCIS)
09/2003

Drug/Important Bio-Agent (IBA)

25TamoxifenFDA LinkGeneric
12/2015 - 09/2003
19letrozole (Femara)FDA LinkGeneric
12/2015 - 12/2005
15HormonesIBA
12/2015 - 06/2004
10Estrogens (Estrogen)FDA Link
12/2015 - 12/2005
4Aromatase InhibitorsIBA
11/2010 - 12/2007
3DNA (Deoxyribonucleic Acid)IBA
12/2015 - 03/2012
3DiphosphonatesIBA
10/2014 - 04/2010
3Aromatase (CYP19)IBA
03/2011 - 12/2005
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2009 - 10/2005
3glucuronyl glucosamine glycan sulfate (Vessel)IBA
06/2008 - 10/2005
2pegylated liposomal doxorubicinIBA
09/2012 - 01/2010
2trastuzumab (Herceptin)FDA Link
01/2011 - 04/2008
2Progesterone Receptors (Progesterone Receptor)IBA
01/2010 - 09/2007
2bevacizumabFDA Link
01/2010 - 04/2008
2Fluorouracil (Carac)FDA LinkGeneric
01/2007 - 10/2005
2Methotrexate (Mexate)FDA LinkGeneric
01/2007 - 10/2005
1Estrogen Receptor alphaIBA
12/2015
1denosumabFDA Link
10/2014
1A 17 (A-17)IBA
10/2014
1OsteocalcinIBA
04/2014
1Alkaline PhosphataseIBA
04/2014
1collagen type I trimeric cross-linked peptideIBA
04/2014
1Phenobarbital (Luminal)FDA Link
02/2013
1Biological Markers (Surrogate Marker)IBA
04/2012
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
04/2012
1Cytochrome P-450 CYP2D6 (CYP2D6)IBA
03/2012
1ibandronic acid (Boniva)FDA Link
01/2010
1RNA (Ribonucleic Acid)IBA
01/2010
1Epirubicin (Ellence)FDA LinkGeneric
01/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2009
1Estrogen ReceptorsIBA
12/2008
1OxygenIBA
04/2008
1lapatinib (GW572016)FDA Link
04/2008
1Phosphotransferases (Kinase)IBA
04/2008
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2008
1ProgesteroneFDA LinkGeneric
09/2007
1fibrinmonomerIBA
07/2007
1docetaxel (Taxotere)FDA Link
07/2007
1Transforming Growth Factor beta (TGF-beta)IBA
07/2007
1Enoxaparin (Lovenox)FDA LinkGeneric
07/2007
1Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
07/2007
1Goserelin (Zoladex)FDA Link
01/2007
1anastrozole (Arimidex)FDA LinkGeneric
06/2004

Therapy/Procedure

12Drug Therapy (Chemotherapy)
02/2014 - 09/2003
6Adjuvant Chemotherapy
01/2015 - 01/2007
2Aftercare (After-Treatment)
09/2012 - 01/2010
1Segmental Mastectomy (Lumpectomy)
02/2014
1Mastectomy (Mammectomy)
02/2014
1Complementary Therapies (Alternative Medicine)
01/2013
1Radiotherapy
05/2007