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Atsushi Sugiyama Selected Research

Halothane (Fluothane)

7/2015Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes.
6/2015Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.
4/2006Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
10/2004Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.
5/2004Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.
2/2004In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
8/2003Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.
8/2002Torsadegenic action of the antipsychotic drug sulpiride assessed using in vivo canine models.

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Atsushi Sugiyama Research Topics

Disease

18Atrioventricular Block
07/2015 - 08/2002
13Torsades de Pointes (Torsade de Pointes)
07/2015 - 04/2002
9Long QT Syndrome
06/2015 - 04/2003
5Heart Failure
08/2015 - 12/2002
5Tachycardia (Tachyarrhythmias)
01/2015 - 07/2002
5Bradycardia
01/2011 - 05/2004
5Neoplasms (Cancer)
02/2006 - 05/2002
4Infection
12/2011 - 04/2002
4Cardiac Arrhythmias (Arrythmia)
01/2011 - 01/2004
4Stomach Neoplasms (Stomach Cancer)
03/2004 - 04/2002
3Heart Arrest (Cardiac Arrest)
06/2015 - 07/2002
3Gastritis
12/2011 - 02/2003
3Atrial Fibrillation
06/2008 - 05/2005
2Hypertension (High Blood Pressure)
06/2015 - 05/2005
2Macular Degeneration (Age-Related Maculopathy)
01/2015 - 09/2014
2Human Influenza (Influenza)
09/2013 - 01/2013
2Premature Cardiac Complexes (Extrasystoles)
01/2011 - 01/2005
2Anoxia (Hypoxia)
04/2005 - 08/2004
2Ventricular Tachycardia
06/2003 - 04/2002
2Carcinoma (Carcinomatosis)
04/2003 - 11/2002
1Death (Near-Death Experience)
07/2015
1Left Ventricular Dysfunction
07/2015
1Parkinson Disease (Parkinson's Disease)
06/2015
1Cataract (Cataracts)
01/2015
1Acidosis
01/2014
1Hepatocellular Carcinoma (Hepatoma)
02/2013
1Retinal Perforations
01/2012
1Hyperalgesia
01/2012
1Neuralgia (Stump Neuralgia)
01/2012
1Stomach Ulcer (Gastric Ulcer)
12/2011
1Duodenal Ulcer (Curling's Ulcer)
12/2011
1Autoimmune Diseases (Autoimmune Disease)
04/2010
1Sinus Tachycardia
02/2010
1Cardiovascular Diseases (Cardiovascular Disease)
02/2010
1Type 2 Diabetes Mellitus (MODY)
11/2006
1Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
11/2006
1Chronic Pancreatitis
02/2006

Drug/Important Bio-Agent (IBA)

8Halothane (Fluothane)FDA Link
07/2015 - 08/2002
5Messenger RNA (mRNA)IBA
01/2011 - 02/2003
4MS 551IBA
01/2014 - 06/2003
4Amiodarone (Amiodarona)FDA LinkGeneric
10/2008 - 08/2002
4sparfloxacin (AT 4140)FDA Link
01/2006 - 06/2003
3cilnidipineIBA
06/2007 - 10/2004
3OxidoreductasesIBA
02/2006 - 04/2005
3tranilast (N 5')IBA
10/2004 - 02/2004
3sematilideIBA
06/2003 - 04/2002
2CytokinesIBA
01/2015 - 04/2005
2Retinaldehyde (Retinal)IBA
01/2015 - 09/2014
2Oseltamivir (Tamiflu)FDA Link
09/2013 - 01/2013
2pilsicainideIBA
01/2013 - 07/2009
2Ion Channels (Ion Channel)IBA
01/2011 - 06/2008
2Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
01/2011 - 10/2005
2salicylhydroxamic acid (SHAM)IBA
11/2008 - 07/2007
2Bepridil (Vascor)FDA Link
10/2008 - 06/2008
2Isoproterenol (Isoprenaline)FDA LinkGeneric
06/2007 - 07/2002
2Acetylcholine (Acetylcholine Chloride)FDA Link
06/2007 - 07/2002
2Terfenadine (Seldane)IBA
03/2006 - 06/2003
2Thymidine PhosphorylaseIBA
01/2006 - 11/2002
2Carbon MonoxideIBA
04/2005 - 04/2003
2Mexiletine (Mexitil)FDA LinkGeneric
01/2004 - 08/2003
2Sulpiride (neogama)IBA
06/2003 - 08/2002
1ONO-AE1-329IBA
08/2015
1Phosphodiesterase 3 InhibitorsIBA
08/2015
1Azithromycin (Zithromax)FDA LinkGeneric
07/2015
1ApomorphineIBA
06/2015
1Dopamine (Intropin)FDA LinkGeneric
06/2015
1Fluvoxamine (Luvox)FDA LinkGeneric
02/2015
1ranibizumab (Lucentis)FDA Link
01/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2015
1Complement Factor H (Factor H)IBA
09/2014
1Steroid 12-alpha-Hydroxylase (CYP8B1)IBA
02/2013
1Conotoxins (Conotoxin)IBA
01/2012
1gabapentin (Neurontin)FDA LinkGeneric
01/2012
1MucinsIBA
12/2011
1trefoil factorIBA
12/2011
1milnacipran (Ixel)FDA Link
12/2010
1Imipramine (Janimine)FDA LinkGeneric
12/2010
1Tacrolimus (Prograf)FDA LinkGeneric
04/2010
1Amlodipine (Norvasc)FDA LinkGeneric
02/2010
1azelnidipineIBA
02/2010
1Pentamidine (NebuPent)FDA LinkGeneric
08/2009
1Charybdotoxin (ChTX)IBA
11/2008
1iberiotoxinIBA
11/2008
1candesartanIBA
02/2007
1Mitochondrial DNA (mtDNA)IBA
11/2006
1Proline (L-Proline)FDA Link
11/2006
1NADH DehydrogenaseIBA
11/2006
1Serine (L-Serine)FDA Link
11/2006
1Histamine (Histamine Dihydrochloride)FDA Link
03/2006
1RNA (Ribonucleic Acid)IBA
02/2006
1PolysaccharidesIBA
02/2006

Therapy/Procedure

3Oral Administration
01/2011 - 06/2003
2Gastrectomy
01/2006 - 05/2002
2Combination Drug Therapy (Combination Chemotherapy)
08/2002 - 05/2002
1Acupuncture Points (Acupuncture Point)
06/2015
1Electroacupuncture
01/2015
1Vitrectomy
01/2012
1Ligation
01/2012
1Organ Transplantation
04/2010
1Transdermal Patch
07/2009