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Clinton F Stewart Selected Research

Topotecan (Hycamtin)

9/2015ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
3/2014Phase I dosage finding and pharmacokinetic study of intravenous topotecan and oral erlotinib in adults with refractory solid tumors.
9/2013Combination metronomic oral topotecan and pazopanib: a pharmacokinetic study in patients with gynecological cancer.
11/2012Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity.
11/2011Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study.
6/2010Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.
1/2010Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia.
7/2009Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.
7/2009Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.
5/2008Phase II study of topotecan in combination with dexamethasone, asparaginase, and vincristine in pediatric patients with acute lymphoblastic leukemia in first relapse.
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Clinton F Stewart Research Topics

Disease

56Neoplasms (Cancer)
09/2015 - 09/2002
15Brain Neoplasms (Brain Tumor)
03/2015 - 09/2002
14Glioma (Gliomas)
10/2013 - 07/2002
13Neuroblastoma
08/2012 - 09/2002
12Diarrhea
08/2012 - 01/2002
11Medulloblastoma
09/2015 - 08/2004
9Breast Neoplasms (Breast Cancer)
07/2011 - 04/2004
8Neutropenia
11/2012 - 01/2006
6Ependymoma
12/2015 - 09/2010
5Exanthema (Rash)
01/2013 - 01/2006
5Leukemia
01/2012 - 03/2002
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2013 - 03/2002
4Disease Progression
10/2013 - 06/2005
4Retinoblastoma (Glioblastoma, Retinal)
11/2012 - 04/2006
3Hemorrhage
05/2015 - 02/2008
3Hearing Loss (Hearing Impairment)
04/2015 - 06/2014
3Central Nervous System Neoplasms
04/2015 - 12/2003
3Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2012 - 05/2008
3Thrombocytopenia (Thrombopenia)
08/2010 - 01/2008
3Wilms Tumor (Wilm's Tumor)
07/2007 - 09/2004
2Osteosarcoma (Osteogenic Sarcoma)
05/2014 - 11/2004
2Pain (Aches)
10/2013 - 08/2008
2Glioblastoma (Glioblastoma Multiforme)
10/2013 - 03/2007
2Pontine Glioma
06/2013 - 11/2010
2Anorexia
01/2013 - 08/2010
2Rhabdomyosarcoma
01/2011 - 09/2002
2Colorectal Neoplasms (Colorectal Cancer)
10/2007 - 03/2004
2Infection
03/2007 - 02/2004
2Renal Insufficiency (Renal Failure)
01/2006 - 09/2004
1Melanoma (Melanoma, Malignant)
01/2015
1Deafness (Deaf Mutism)
06/2014
1Body Weight (Weight, Body)
05/2014

Drug/Important Bio-Agent (IBA)

27Topotecan (Hycamtin)FDA LinkGeneric
09/2015 - 03/2002
21irinotecan (Camptosar)FDA LinkGeneric
08/2012 - 01/2002
11gefitinib (Iressa)FDA Link
08/2012 - 10/2004
8temozolomide (Temodar)FDA LinkGeneric
01/2011 - 11/2003
6Epidermal Growth Factor Receptor (EGF Receptor)IBA
12/2010 - 09/2005
5ATP-Binding Cassette Transporters (ABC Transporters)IBA
09/2015 - 04/2006
5erlotinib (CP 358,774)FDA Link
03/2014 - 03/2007
5Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2013 - 01/2006
5Vincristine (Oncovin)FDA LinkGeneric
11/2012 - 05/2008
5Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2010 - 09/2005
4bevacizumabFDA Link
05/2015 - 07/2007
4lapatinib (GW572016)FDA Link
05/2015 - 02/2006
4Cisplatin (Platino)FDA LinkGeneric
04/2015 - 08/2008
4Phosphotransferases (Kinase)IBA
01/2015 - 01/2009
4glucuronyl glucosamine glycan sulfate (Vessel)IBA
04/2012 - 01/2007
4P-GlycoproteinIBA
06/2010 - 04/2006
3Fluorouracil (Carac)FDA LinkGeneric
12/2015 - 10/2007
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2015 - 07/2007
3Methotrexate (Mexate)FDA LinkGeneric
04/2015 - 09/2012
3Amifostine (Ethyol)FDA LinkGeneric
06/2014 - 08/2008
3Adenosine Triphosphate (ATP)IBA
03/2014 - 04/2006
3N- (4- bromo- 2- fluorophenyl)- 6- methoxy- 7- ((1- methylpiperidin- 4- yl)methoxy)quinazolin- 4- amine (ZD6474)IBA
06/2013 - 11/2010
3Lipase (Acid Lipase)FDA Link
01/2013 - 01/2009
3Dexamethasone (Maxidex)FDA LinkGeneric
11/2010 - 05/2008
3oxaliplatin (Eloxatin)FDA LinkGeneric
04/2009 - 06/2007
3Anticonvulsants (Antiepileptic Drugs)IBA
01/2009 - 07/2002
39 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA
01/2007 - 03/2002
3CamptothecinIBA
01/2006 - 04/2004
2CilengitideIBA
10/2013 - 02/2008
2Proteins (Proteins, Gene)IBA
09/2013 - 04/2006
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
06/2013 - 11/2010
23-Iodobenzylguanidine (Iobenguane)IBA
08/2012 - 01/2011
2Carboplatin (JM8)FDA LinkGeneric
04/2012 - 01/2005
2Asparaginase (Elspar)FDA Link
01/2012 - 05/2008
2nutlin 3IBA
07/2011 - 01/2011
2OSI-420IBA
01/2011 - 01/2009
2Adrenal Cortex Hormones (Corticosteroids)IBA
11/2010 - 08/2008
2tranilast (N 5')IBA
06/2010 - 01/2006
2CladribineFDA LinkGeneric
01/2010 - 10/2002
2EnzymesIBA
07/2009 - 04/2009
2Cefixime (Suprax)FDA Link
03/2009 - 02/2006
2Etoposide (VP 16)FDA LinkGeneric
02/2009 - 01/2005
2DNA (Deoxyribonucleic Acid)IBA
12/2008 - 02/2008
2laromustine (VNP40101M)IBA
02/2008 - 06/2007
2Histone Deacetylase InhibitorsIBA
08/2006 - 01/2006
25- (3- methyl- 1- triazeno)imidazole- 4- carboxamide (MTIC)IBA
12/2003 - 11/2003
14- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
09/2015
1Deoxyadenosines (Deoxyadenosine)IBA
05/2015
1Carbon MonoxideIBA
05/2015
1clofarabine (Clolar)FDA Link
05/2015
1CreatinineIBA
05/2015
1corrigendumIBA
04/2015
1aurora kinase (aurora A kinase)IBA
01/2015
1pemetrexed (MTA)FDA Link
04/2014
1gemcitabineFDA Link
04/2014
1pazopanibIBA
09/2013
1Drug CombinationsIBA
06/2013
1dipinacoline glutamateIBA
06/2013
1Platelet-Derived Growth FactorIBA
06/2013
1dasatinib (BMS 354825)FDA Link
06/2013

Therapy/Procedure

15Drug Therapy (Chemotherapy)
09/2015 - 11/2003
13Heterologous Transplantation (Xenotransplantation)
05/2015 - 09/2002
7Radiotherapy
06/2013 - 02/2006
2Hearing Aids (Hearing Aid)
06/2014 - 08/2008
2Renal Dialysis (Hemodialysis)
01/2006 - 09/2004
1Tracheostomy
05/2015
1Homologous Transplantation (Allograft)
05/2015
1Therapeutics
01/2015