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James P Stables Selected Research

Pentylenetetrazole (Metrazol)

6/2013Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.
1/2012A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
6/2011Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.
12/2010Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties.
7/20101,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.
4/2010Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives.
2/2010Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
11/2009A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones.
9/2009Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene.
4/2009Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.
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James P Stables Research Topics

Disease

33Seizures (Seizure)
06/2013 - 03/2002
11Epilepsy (Aura)
01/2012 - 08/2002
2Pain (Aches)
10/2011 - 05/2010
2Magnesium Deficiency (Deficiency, Magnesium)
12/2010 - 07/2010
2Colonic Neoplasms (Colon Cancer)
09/2007 - 10/2002
2Generalized Epilepsy
05/2007 - 01/2007
1Status Epilepticus (Complex Partial Status Epilepticus)
01/2012
1Neuralgia (Stump Neuralgia)
10/2011
1Hypothermia
12/2010
1Poisoning
07/2010
1Wounds and Injuries (Trauma)
07/2010
1Hyperalgesia
05/2010
1Carcinoma (Carcinomatosis)
03/2010
1Neoplasms (Cancer)
03/2010
1Body Weight (Weight, Body)
03/2009
1Brain Injuries (Brain Injury)
04/2008
1Lymphoid Leukemia
04/2008
1Leukemia
09/2007

Drug/Important Bio-Agent (IBA)

21Pentylenetetrazole (Metrazol)IBA
06/2013 - 03/2002
6Anticonvulsants (Antiepileptic Drugs)IBA
10/2011 - 09/2003
5N-Methylaspartate (NMDA)IBA
12/2010 - 02/2003
5lacosamideFDA Link
08/2010 - 05/2007
4Glutamic Acid (Glutamate)FDA Link
01/2012 - 08/2002
3BicucullineIBA
01/2012 - 05/2007
3gamma-Aminobutyric Acid (GABA)IBA
01/2012 - 08/2002
3PicrotoxinIBA
12/2010 - 05/2007
3StrychnineIBA
07/2008 - 09/2002
2pyrazoleIBA
06/2013 - 12/2012
2Formaldehyde (Formol)FDA Link
10/2011 - 05/2010
2Pilocarpine (Ocusert)FDA LinkGeneric
12/2010 - 08/2002
2Melphalan (Alkeran)FDA LinkGeneric
09/2007 - 10/2002
2HydrazonesIBA
03/2003 - 08/2002
1dipropylacetamide (valpromide)IBA
01/2012
1SomanIBA
01/2012
1AcetamidesIBA
10/2011
1asaroneIBA
12/2010
1Pentobarbital (Nembutal)FDA Link
12/2010
1Superoxide DismutaseIBA
12/2010
1compound 20IBA
11/2010
1compound 17IBA
11/2010
1Superoxides (Superoxide)IBA
07/2010
1Cerebral preparationIBA
07/2010
11,2-ethane bis-1-amino-4-benzamidineIBA
07/2010
1BenzamidinesIBA
07/2010
1FCE 26743IBA
05/2010
1nafimidone alcoholIBA
04/2010
1ProdrugsIBA
04/2010
1CytotoxinsIBA
03/2010
1Caspase 3 (Caspase-3)IBA
03/2010
14,4'-thiodianilineIBA
09/2009
1Bridged CompoundsIBA
09/2009
1Sodium Channels (Sodium Channel)IBA
01/2009
1Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
07/2008
1Ethosuximide (Zarontin)FDA LinkGeneric
07/2008
1rufinamideFDA Link
07/2008
1Phenytoin (Dilantin)FDA LinkGeneric
07/2008
1Phenobarbital (Luminal)FDA Link
07/2008
1lamotrigine (Lamictal)FDA LinkGeneric
06/2008
13- (2,3,5- trichlorophenyl)pyrazine- 2,6- diamineIBA
06/2008
1rosiglitazone (Avandia)FDA Link
04/2008
12-chloro-5-nitrobenzanilideIBA
04/2008
1(N- (9- fluorenylmethoxycarbonyl)- )- L- leucineIBA
04/2008
1IsoflavonesIBA
04/2008
1Leucine (L-Leucine)FDA Link
04/2008
1LigandsIBA
04/2008
1MagnesiumIBA
04/2008
1PPAR gammaIBA
04/2008
1HomocysteineIBA
05/2007
1Ion Channels (Ion Channel)IBA
01/2007
1AmidesIBA
06/2004
1Messenger RNA (mRNA)IBA
08/2003
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
08/2003
1Dizocilpine Maleate (Dizocilpine)IBA
08/2003
1SemicarbazonesIBA
03/2003
1AgmatineIBA
02/2003
14-O-carboxymethylascochlorinIBA
02/2003
1Affinity LabelsIBA
10/2002
1Amino AcidsFDA Link
10/2002
1Kainic Acid Receptors (Kainate Receptor)IBA
08/2002
1Mannich BasesIBA
08/2002
1IsatinIBA
08/2002

Therapy/Procedure

1Ligation
05/2010
1Therapeutics
12/2003