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Diogo O Souza Selected Research

Quinolinic Acid

2/2010Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model.
1/2008Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines.
4/2005In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine.
2/2005Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
1/2005Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice.
1/2005Effects of chronic administered guanosine on behavioral parameters and brain glutamate uptake in rats.
4/2004Anticonvulsant effect of GMP depends on its conversion to guanosine.
8/2003Effects of undernutrition on glutamatergic parameters in rat brain.

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Diogo O Souza Research Topics

Disease

13Seizures (Seizure)
08/2011 - 01/2003
8Schizophrenia (Dementia Praecox)
01/2015 - 10/2002
6Pain (Aches)
11/2015 - 10/2008
6Ischemia
10/2014 - 06/2002
6Bipolar Disorder (Mania)
04/2011 - 12/2004
6Malnutrition
07/2008 - 06/2002
5Alzheimer Disease (Alzheimer's Disease)
01/2013 - 04/2003
4Brain Diseases (Brain Disorder)
02/2015 - 10/2003
4Brain Injuries (Brain Injury)
09/2013 - 09/2004
4Epilepsy (Aura)
08/2011 - 01/2005
4Body Weight (Weight, Body)
10/2010 - 04/2006
3Anoxia (Hypoxia)
03/2014 - 04/2004
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2013 - 10/2006
3Dementia (Dementias)
01/2013 - 01/2003
3Nervous System Diseases (Neurological Disorders)
01/2012 - 09/2002
2Diabetes Mellitus
06/2015 - 02/2012
2Brain Ischemia (Cerebral Ischemia)
10/2014 - 10/2003
2Stroke (Strokes)
10/2014 - 07/2003
2Insulin Resistance
12/2013 - 02/2012
2Memory Disorders (Memory Loss)
01/2012 - 01/2010
2Amnesia (Dissociative Amnesia)
10/2011 - 01/2007
2Hyperalgesia
02/2010 - 02/2009
2Parkinson Disease (Parkinson's Disease)
08/2009 - 01/2005
2Vertigo (Positional Vertigo)
07/2005 - 01/2005
2Catalepsy
07/2005 - 01/2005
2Migraine Disorders (Migraine)
07/2005 - 01/2005
2Chronic Disease (Chronic Diseases)
07/2004 - 01/2002
1Reperfusion Injury
11/2015
1Labor Pain
11/2015
1Pancreatitis
05/2015
1Sepsis (Septicemia)
05/2015
1Anxiety Disorders (Anxiety Disorder)
01/2015
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/2014
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2013
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
01/2011
1Metabolic Diseases (Metabolic Disease)
10/2010
1Glucose Intolerance
10/2010

Drug/Important Bio-Agent (IBA)

18Glutamic Acid (Glutamate)FDA Link
01/2015 - 01/2003
12GuanosineIBA
04/2010 - 04/2004
9PurinesIBA
11/2015 - 04/2004
8Quinolinic AcidIBA
02/2010 - 08/2003
7AdenosineFDA LinkGeneric
11/2015 - 10/2002
7N-Methylaspartate (NMDA)IBA
01/2015 - 01/2003
7GuanineIBA
02/2010 - 04/2004
6Dizocilpine Maleate (Dizocilpine)IBA
02/2010 - 01/2003
5Caffeine (No Doz)FDA LinkGeneric
01/2013 - 04/2003
5Biological Markers (Surrogate Marker)IBA
01/2010 - 01/2002
55'-Guanylic Acid (GMP)IBA
10/2008 - 06/2002
5S-100 calcium-binding protein beta subunitIBA
12/2007 - 12/2004
4ebselenIBA
11/2004 - 09/2002
3OxygenIBA
11/2015 - 10/2003
3Glucose (Dextrose)FDA LinkGeneric
11/2015 - 10/2003
3Glutamate Receptors (Glutamate Receptor)IBA
02/2015 - 06/2002
3RiluzoleFDA LinkGeneric
11/2013 - 01/2003
3Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
01/2013 - 01/2010
3Purinergic P1 Receptors (Adenosine Receptor)IBA
01/2013 - 01/2007
3Kainic Acid (Kainate)IBA
08/2011 - 06/2002
3LithiumIBA
04/2011 - 06/2007
3AdenineFDA LinkGeneric
02/2010 - 10/2008
3Phosphopyruvate Hydratase (Enolase)IBA
01/2010 - 01/2005
3Neurotransmitter Agents (Neurotransmitter)IBA
07/2008 - 11/2002
3Amphetamine (Amfetamine)FDA LinkGeneric
07/2005 - 01/2003
21,4-dihydropyridine (dihydropyridine)IBA
02/2015 - 10/2014
2Cytochromes c (Cytochrome c)IBA
10/2014 - 10/2014
2Excitatory Amino AcidsIBA
10/2014 - 02/2009
2Insulin (Novolin)FDA Link
01/2012 - 10/2011
2Brain-Derived Neurotrophic Factor (BDNF)IBA
04/2011 - 01/2007
2Uric Acid (Urate)IBA
08/2010 - 04/2010
2InosineFDA Link
04/2010 - 09/2004
2Excitatory Amino Acid AgentsIBA
02/2010 - 12/2007
2Proteins (Proteins, Gene)IBA
01/2010 - 08/2004
2Adenosine Diphosphate (ADP)IBA
12/2008 - 09/2004
2Allopurinol (Remid)FDA LinkGeneric
08/2008 - 01/2003
2Superoxide DismutaseIBA
06/2007 - 02/2004
2Calcium Channels (Calcium Channel)IBA
07/2005 - 01/2005
2Guanosine Diphosphate (GDP)IBA
01/2005 - 09/2004
2dendrotoxinIBA
01/2005 - 01/2005
2SeleniumIBA
11/2004 - 10/2003
1AlloxanIBA
06/2015
1Taurocholic Acid (Sodium Taurocholate)IBA
05/2015
1BenzodiazepinesIBA
02/2015
1mitochondrial permeability transition poreIBA
10/2014
1Diazepam (Valium)FDA LinkGeneric
10/2014
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
03/2014
1PC 12IBA
03/2014
1Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
12/2013
1OxidoreductasesIBA
09/2013
1triphenyltetrazoliumIBA
09/2013
1Amyloid (Amyloid Fibrils)IBA
01/2013
1Streptozocin (Streptozotocin)FDA Link
01/2013
1Non-alcoholic Fatty Liver DiseaseIBA
02/2012
1Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
08/2011
1DAPIIBA
08/2011
1Methylphenidate (Ritalin)FDA LinkGeneric
01/2011
1olanzapine (Zyprexa)FDA Link
10/2010
1GhrelinIBA
09/2010

Therapy/Procedure

4Therapeutics
04/2011 - 06/2007
2Ligation
05/2015 - 02/2010
1Intraperitoneal Injections
06/2015
1Oral Administration
10/2014