Mark A Smith Selected Research

Alzheimer Disease (Alzheimer's Disease)

08/2008	Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis.
04/2008	Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease.
02/2008	Alzheimer disease and the role of free radicals in the pathogenesis of the disease.
01/2008	Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer's disease.
01/2008	Retinoblastoma Protein Phosphorylation at Multiple Sites is Associated with Neurofibrillary Pathology in Alzheimer Disease.
01/2008	Menopause, estrogen, and gonadotropins in Alzheimer's disease.
12/2007	Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease.
12/2007	Evidence for the role of luteinizing hormone in Alzheimer disease.
12/2007	The role of novel chitin-like polysaccharides in Alzheimer disease.
10/2007	Iron: the Redox-active center of oxidative stress in Alzheimer disease.
09/2007	The contribution of luteinizing hormone to Alzheimer disease pathogenesis.
09/2007	Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.
06/2007	Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
02/2007	Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain.
02/2007	Prevention and treatment of Alzheimer disease and aging: antioxidants.
01/2007	Gonadotropins: a cohesive gender-based etiology of Alzheimer disease.
01/2007	Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
12/2006	Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
12/2006	Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
10/2006	Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance.
07/2006	Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
03/2006	Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
01/2006	Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.
01/2006	Heme deficiency in Alzheimer's disease: a possible connection to porphyria.
01/2006	Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss!
01/2006	Targeting gonadotropins: an alternative option for Alzheimer disease treatment.
01/2006	The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease.
01/2006	The fallacy of amyloid and cognition in Alzheimer's disease.
10/2005	Chitin-like polysaccharides in Alzheimer's disease brains.
09/2005	Nanoparticle and other metal chelation therapeutics in Alzheimer disease.
06/2005	Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease.
06/2005	Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
06/2005	Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?
04/2005	Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis.
04/2005	The gonadotropin connection in Alzheimer's disease.
03/2005	Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease.
02/2005	Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
02/2005	Insulin signaling, diabetes mellitus and risk of Alzheimer disease.
10/2004	Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.
08/2004	Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?
08/2004	Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease.
07/2004	Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
07/2004	Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
06/2004	Homocysteine and Alzheimer's disease: a modifiable risk?
06/2004	Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
05/2004	The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease.
04/2004	Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
04/2004	Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species.
03/2004	Oxidative stress and redox-active iron in Alzheimer's disease.
03/2004	Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
01/2004	Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection.
01/2004	The role of metabotropic glutamate receptors in Alzheimer's disease.
08/2003	Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
06/2003	Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
05/2003	Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?
03/2003	Estrogen replacement and risk of Alzheimer disease.
03/2003	Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.
11/2002	Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology.
09/2002	Differential regulation of glutamate receptors in Alzheimer's disease.
09/2002	The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
07/2002	Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis.
07/2002	The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
06/2002	Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle.
05/2002	Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
01/2002	Iron: a pathological mediator of Alzheimer disease?

Articles by Research Topic

Disease

65	Alzheimer Disease (Alzheimer's Disease) 08/2008 - 01/2002
5	Neuroblastoma 05/2008 - 06/2004
4	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2006 - 01/2002
3	Dementia (Dementias) 02/2005 - 11/2002
2	Psychotic Disorders (Schizoaffective Disorder) 02/2008 - 10/2007
2	Parkinson Disease (Parkinson's Disease) 01/2008 - 04/2006
1	Dissociative Disorders (Fugue) 08/2008
1	Tauopathies 01/2008
1	Schizophrenia (Dementia Praecox) 10/2007
1	Bipolar Disorder (Mania) 10/2007
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2007
1	Anoxia (Hypoxia) 01/2007
1	Glioma (Gliomas) 12/2006
1	Nervous System Diseases (Neurological Disorders) 10/2006
1	Porphyrias 01/2006
1	DNA Damage 09/2005
1	Diabetes Mellitus 02/2005
1	Cerebral Hemorrhage 02/2003
1	Parkinsonian Disorders (Parkinsonism) 02/2003
1	Hemorrhage 11/2002
1	Wounds and Injuries (Trauma) 09/2002
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2002

Drug/Important Bio-Agent (IBA)

13	Amyloid (Amyloid Fibrils)IBA 12/2007 - 05/2002
11	IronIBA 10/2007 - 01/2002
7	GonadotropinsIBA 01/2008 - 01/2004
4	Luteinizing Hormone (Lutropin)FDA LinkGeneric 12/2007 - 11/2002
3	Estrogens (Estrogen)FDA Link 01/2008 - 08/2004
3	alpha-SynucleinIBA 01/2008 - 07/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2006 - 05/2004
3	RNA (Ribonucleic Acid)IBA 01/2006 - 11/2002
3	CopperIBA 07/2004 - 01/2002
2	quetiapine (Seroquel)FDA Link 02/2008 - 10/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2008 - 03/2005
2	PolysaccharidesIBA 12/2007 - 10/2005
2	ChitinIBA 12/2007 - 10/2005
2	Heme (Haem)IBA 01/2006 - 10/2004
2	Histones (Histone)IBA 09/2005 - 05/2003
1	AntigensIBA 08/2008
1	SB 415286IBA 05/2008
1	Hydrogen Peroxide (Hydroperoxide)IBA 05/2008
1	tau Proteins (tau Protein)IBA 04/2008
1	Free RadicalsIBA 02/2008
1	Retinoblastoma ProteinIBA 01/2008
1	Leucine (L-Leucine)FDA Link 01/2008
1	Phosphotransferases (Kinase)IBA 01/2008
1	Carbon MonoxideIBA 10/2007
1	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 10/2007
1	Thioctic Acid (Lipoic Acid)IBA 09/2007
1	Cysteine (L-Cysteine)FDA Link 09/2007
1	AntioxidantsIBA 02/2007
1	OsteopontinIBA 02/2007
1	TrichosanthinIBA 01/2007
1	IsoprostanesIBA 01/2007
1	karyopherin alpha 2IBA 12/2006
1	Transforming Growth Factor beta (TGF-beta)IBA 12/2006
1	ClusterinIBA 11/2006
1	Chelating AgentsIBA 10/2006
1	catechol (pyrocatechol)IBA 04/2006
1	PresenilinsIBA 03/2006
1	steroidogenic acute regulatory proteinIBA 01/2006
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2006
1	Cyclin-Dependent Kinase 2IBA 09/2005
1	QuinonesIBA 06/2005
1	Ribosomal RNAIBA 06/2005
1	mitogen and stress-activated protein kinase 1IBA 02/2005
1	Testosterone (Sustanon)FDA LinkGeneric 02/2005
1	Insulin (Novolin)FDA Link 02/2005
1	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 10/2004
1	HormonesIBA 08/2004
1	Glycogen Synthase (Synthase I)IBA 06/2004
1	HomocysteineIBA 06/2004
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2004
1	metabotropic glutamate receptor 2IBA 04/2004
1	Cyclin BIBA 03/2004
1	Amyloid beta-ProteinIBA 02/2004
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2004
1	Wiskott-Aldrich Syndrome Protein FamilyIBA 08/2003
1	MelatoninIBA 06/2003
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 02/2003
1	Protons (Proton)IBA 02/2003
1	Glutamic Acid (Glutamate)FDA Link 09/2002
1	Glutamate Receptors (Glutamate Receptor)IBA 09/2002
1	Protein Kinases (Protein Kinase)IBA 09/2002
1	CholesterolIBA 07/2002
1	Cell Cycle ProteinsIBA 06/2002
1	Nucleic AcidsIBA 04/2002

Therapy/Procedure

2	Estrogen Replacement Therapy 01/2004 - 03/2003
1	Therapeutics 09/2005