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Charles D Smith Selected Research

3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amide

12/2015The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
12/2015Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
9/2015Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.
1/2014Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
10/2013Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
1/2012Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
12/2011Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.
4/2011Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
4/2011Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
3/2011Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
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Charles D Smith Research Topics

Disease

39Neoplasms (Cancer)
12/2015 - 01/2003
8Alzheimer Disease (Alzheimer's Disease)
01/2015 - 06/2006
7Inflammation
12/2015 - 11/2006
7Dementia (Dementias)
10/2014 - 11/2004
5Prostatic Neoplasms (Prostate Cancer)
12/2015 - 07/2008
4Frontotemporal Lobar Degeneration (Semantic Dementia)
07/2015 - 06/2006
4Parkinson Disease (Parkinson's Disease)
11/2013 - 02/2005
4Adenocarcinoma
12/2011 - 04/2010
4Muscular Diseases (Myopathy)
03/2008 - 06/2006
3Lymphoma (Lymphomas)
09/2015 - 01/2009
3Sclerosis
07/2015 - 05/2011
3Anoxia (Hypoxia)
11/2013 - 01/2012
3Arthritis (Polyarthritis)
10/2013 - 03/2009
3Carcinoma (Carcinomatosis)
12/2011 - 05/2010
3Breast Neoplasms (Breast Cancer)
04/2011 - 06/2008
3Hematologic Neoplasms (Hematological Malignancy)
01/2011 - 06/2009
3Melanoma (Melanoma, Malignant)
06/2008 - 03/2005
3Osteitis Deformans (Paget's Disease of Bone)
02/2007 - 06/2006
3Frontotemporal Dementia
02/2007 - 06/2006
2Epilepsy (Aura)
07/2015 - 10/2005
2Ischemia
11/2013 - 01/2012
2Hepatocellular Carcinoma (Hepatoma)
08/2011 - 03/2011
2Giardiasis
08/2011 - 08/2011
2Colonic Neoplasms (Colon Cancer)
08/2011 - 10/2010
2Weight Loss (Weight Reduction)
11/2010 - 01/2003
2Disease Progression
04/2010 - 04/2008
2Leukemia
06/2009 - 01/2009
1Gliosis
07/2015
1Arteriolosclerosis
07/2015
1Lung Neoplasms (Lung Cancer)
06/2015
1Hypothyroidism
01/2015
1Thyroid Neoplasms (Thyroid Cancer)
01/2015
1Primary Effusion Lymphoma
01/2014
1Reperfusion Injury
11/2013
1Asthma (Bronchial Asthma)
10/2013
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2013
1Cerebral Hemorrhage
05/2013

Drug/Important Bio-Agent (IBA)

163- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA
12/2015 - 04/2010
13sphingosine kinaseIBA
12/2015 - 09/2003
12SphingosineIBA
12/2015 - 01/2011
11sorafenib (BAY 43-9006)FDA Link
01/2013 - 08/2006
9Phosphotransferases (Kinase)IBA
12/2015 - 03/2005
7sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
12/2015 - 11/2011
6Proteins (Proteins, Gene)IBA
12/2015 - 11/2006
6Protein Kinases (Protein Kinase)IBA
01/2010 - 03/2005
5Biological Markers (Surrogate Marker)IBA
07/2015 - 06/2006
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2013 - 11/2006
4Small Interfering RNA (siRNA)IBA
10/2013 - 03/2005
4P-GlycoproteinIBA
07/2011 - 01/2003
4ApolipoproteinsIBA
05/2011 - 03/2006
3EnzymesIBA
12/2015 - 04/2010
3CeramidesIBA
09/2015 - 11/2011
3HormonesIBA
01/2015 - 04/2011
3Doxorubicin (Adriamycin)FDA LinkGeneric
08/2011 - 01/2003
3Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
04/2007 - 02/2005
3CDC48 proteinIBA
02/2007 - 06/2006
2Eosine Yellowish-(YS) (Eosin)IBA
07/2015 - 05/2011
2protein TDP-43 (TDP-43)IBA
07/2015 - 02/2007
2Messenger RNA (mRNA)IBA
01/2012 - 07/2006
2Quinacrine (Mepacrine)IBA
08/2011 - 08/2011
2Fluorouracil (Carac)FDA LinkGeneric
08/2011 - 08/2011
2Antimitotic AgentsIBA
07/2011 - 07/2007
2DNA (Deoxyribonucleic Acid)IBA
07/2011 - 05/2011
2Serine (L-Serine)FDA Link
01/2011 - 01/2010
2Threonine (L-Threonine)FDA Link
01/2011 - 01/2010
2proto-oncogene proteins pimIBA
01/2011 - 01/2010
2Dextran SulfateIBA
10/2010 - 04/2008
2Apolipoprotein E4IBA
10/2010 - 07/2010
2olsalazine (Dipentum)FDA Link
04/2010 - 04/2008
2UbiquitinIBA
02/2007 - 06/2006
2Apolipoproteins E (ApoE)IBA
01/2007 - 03/2006
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2006 - 03/2005
2N- 1- benzyl- 2,3- dihydro- 1H- pyrrolo(2,3- b)quinolin- 4- yl- 2- phenylacetamideIBA
03/2004 - 01/2003
1SphingolipidsIBA
12/2015
1Androgen Receptors (Androgen Receptor)IBA
12/2015
1dihydroceramide desaturaseIBA
12/2015
1NexusIBA
10/2015
1Hematoxylin (Haematoxylon)IBA
07/2015
1Telomerase (Telomerase Reverse Transcriptase)IBA
06/2015
1Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
01/2015
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
01/2014
1Tetracycline (Achromycin)FDA LinkGeneric
11/2013
1Minocycline (Cyclops)FDA LinkGeneric
11/2013
1mitochondrial calcium uniporterIBA
11/2013
1compound 20IBA
11/2013
1Propidium (Propidium Iodide)IBA
11/2013
1Doxycycline (Vibramycin)FDA LinkGeneric
11/2013
1Iodoacetic AcidIBA
11/2013
1Ru 360IBA
11/2013
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
05/2013
1SulfurIBA
03/2013
1mapatumumabIBA
01/2013
1AntibodiesIBA
01/2013
1lexatumumabIBA
01/2013

Therapy/Procedure

14Heterologous Transplantation (Xenotransplantation)
12/2015 - 07/2007
6Drug Therapy (Chemotherapy)
11/2013 - 01/2003
3Oral Administration
12/2015 - 04/2010
3Therapeutics
04/2010 - 11/2006
1Castration
12/2015
1Estrogen Replacement Therapy
01/2013