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Donald F Smee Selected Research

Antiviral Agents (Antivirals)

1/2015Enhanced efficacy of cidofovir combined with vaccinia immune globulin in treating progressive cutaneous vaccinia virus infections in immunosuppressed hairless mice.
11/2013Favipiravir (T-705), a novel viral RNA polymerase inhibitor.
12/2012Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs.
10/2012Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents.
1/2011Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir.
1/2011Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances.
6/2010Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.
1/2010Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice.
1/2010Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.
6/2008C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection.
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Donald F Smee Research Topics

Disease

62Infection
09/2015 - 05/2002
32Human Influenza (Influenza)
09/2015 - 05/2002
7Vaccinia
01/2015 - 09/2004
7Body Weight (Weight, Body)
11/2014 - 05/2002
6Cowpox
01/2013 - 05/2002
5Weight Loss (Weight Reduction)
09/2015 - 01/2011
5Respiratory Tract Infections (Respiratory Tract Infection)
01/2011 - 05/2002
4Influenza in Birds (Avian Flu)
11/2011 - 04/2006
3Fever (Fevers)
10/2011 - 01/2006
3Virus Diseases (Viral Diseases)
06/2010 - 03/2006
3Smallpox (Variola)
01/2008 - 06/2003
3Monkeypox
06/2003 - 05/2002
2Arenaviridae Infections
09/2015 - 01/2010
2Yellow Fever
11/2014 - 11/2013
2Severe Acute Respiratory Syndrome
04/2011 - 01/2004
1Viral Hemorrhagic Fevers (Viral Hemorrhagic Fever)
09/2015
1Viremia
11/2014
1Phlebotomus Fever (Sandfly Fever)
11/2013
1Poliomyelitis (Polio)
11/2013
1Rift Valley Fever
11/2013
1Dengue (Dengue Fever)
01/2012
1RNA Virus Infections
10/2011
1Thrombocytopenia (Thrombopenia)
10/2011
1Hemorrhagic Fever with Renal Syndrome (HFRS)
01/2011
1Carcinoma (Carcinomatosis)
06/2008
1Hepatitis
04/2008
1Pneumonia (Pneumonitis)
04/2008
1Schizophrenia (Dementia Praecox)
02/2008
1Autistic Disorder (Autism)
02/2008

Drug/Important Bio-Agent (IBA)

17cidofovir (Vistide)FDA Link
01/2015 - 05/2002
16Ribavirin (Virazole)FDA LinkGeneric
01/2012 - 05/2002
15Oseltamivir (Tamiflu)FDA Link
08/2014 - 09/2004
13Antiviral Agents (Antivirals)IBA
01/2015 - 07/2002
116-fluoro-3-hydroxy-2-pyrazinecarboxamideIBA
09/2015 - 06/2009
8Neuraminidase (Sialidase)IBA
06/2014 - 05/2002
7InterferonsIBA
01/2013 - 01/2003
6peramivirIBA
06/2014 - 05/2002
5Amantadine (Aman)FDA LinkGeneric
01/2012 - 10/2002
4Interferon-alpha (Interferon Alfa)FDA Link
01/2013 - 01/2003
4N-methanocarbathymidineIBA
01/2008 - 01/2007
4OxygenIBA
03/2007 - 05/2002
3Zanamivir (Relenza)FDA Link
06/2014 - 10/2002
3Dihydrotachysterol (AT 10)IBA
01/2013 - 01/2006
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2011 - 06/2002
3cyanovirin NIBA
12/2008 - 08/2003
3purineIBA
12/2006 - 05/2002
2ST-246IBA
01/2015 - 01/2008
2Viral RNAIBA
11/2013 - 06/2009
2DNA-Directed RNA Polymerases (RNA Polymerase)IBA
04/2012 - 06/2009
2thiazole-4-carboxamide adenine dinucleotide (TCAD)IBA
01/2012 - 01/2010
2T 1106IBA
05/2010 - 01/2009
2carbodineIBA
04/2010 - 12/2008
2CytosineIBA
04/2010 - 05/2002
2Interferon-gamma (Interferon, gamma)IBA
01/2010 - 06/2006
2DNA (Deoxyribonucleic Acid)IBA
12/2007 - 03/2006
2S 2242IBA
12/2006 - 05/2002
2oseltamivir carboxylateIBA
01/2006 - 10/2002
2Interferon InducersIBA
01/2003 - 01/2003
2Cyclopentanes (Cyclopentane)IBA
06/2002 - 05/2002
1Alanine Transaminase (SGPT)IBA
11/2014
1AdenosineFDA LinkGeneric
11/2014
1Drug CombinationsIBA
06/2014
1antineoplaston A10 (A 10)IBA
01/2013
12-deoxy-2,3-dehydro-N-acetylneuraminic acidIBA
12/2012
1pyrimidineIBA
01/2012
1everolimusFDA Link
01/2012
1Butyric Acid (Butanoic Acid)IBA
01/2012
1Small Interfering RNA (siRNA)IBA
01/2012
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
10/2011
1imiquimod (Aldara)FDA LinkGeneric
06/2011
1AcetylglucosamineIBA
04/2011
1stinging nettle lectinIBA
04/2011
1TeaIBA
01/2011
1RNA (Ribonucleic Acid)IBA
01/2011
1IntegrinsIBA
01/2011
1Ribose (D-Ribose)IBA
04/2010
1Aurintricarboxylic AcidIBA
01/2010
1Sulfamethazine (Sulfadimidine)IBA
01/2010
1PyrazinamideFDA LinkGeneric
01/2010
1aristeromycinIBA
01/2010
1Ethacrynic Acid (Etacrynic Acid)FDA Link
01/2010
1EnzymesIBA
06/2009
1PlacebosIBA
12/2008
1Interleukin-6 (Interleukin 6)IBA
04/2008
1CytokinesIBA
04/2008
1ChemokinesIBA
04/2008
1salicylhydroxamic acid (SHAM)IBA
02/2008
1Semaphorin-3AIBA
02/2008
1Thymidine KinaseIBA
01/2008
1triphosphoric acid (triphosphate)IBA
01/2008
1Ethyl Ether (Ether)IBA
01/2008
1ProdrugsIBA
01/2008
19- (3- hydroxy- 2- phosphonylmethoxypropyl)adenineIBA
01/2008
1Idoxuridine (Stoxil)FDA LinkGeneric
01/2008
1Bromodeoxyuridine (BrdU)IBA
01/2008
1Mitoxantrone (Novantrone)FDA LinkGeneric
12/2007

Therapy/Procedure

3Drug Therapy (Chemotherapy)
01/2011 - 01/2003
2Aftercare (After-Treatment)
11/2014 - 12/2008
1Combination Drug Therapy (Combination Chemotherapy)
10/2010
1Oral Administration
01/2008