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Dennis J Slamon Selected Research

human AKT2 protein

1/2003Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

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Dennis J Slamon Research Topics

Disease

45Breast Neoplasms (Breast Cancer)
06/2015 - 02/2002
41Neoplasms (Cancer)
08/2015 - 03/2002
9Ovarian Neoplasms (Ovarian Cancer)
08/2015 - 01/2003
4Neoplasm Metastasis (Metastasis)
02/2015 - 03/2002
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2014 - 07/2010
4Retinoblastoma (Glioblastoma, Retinal)
08/2013 - 03/2002
4Disease Progression
08/2010 - 03/2004
3Fatigue
01/2015 - 07/2002
3Diarrhea
01/2011 - 02/2007
3Lung Neoplasms (Lung Cancer)
12/2010 - 06/2002
2Neutropenia
01/2015 - 04/2002
2Hepatocellular Carcinoma (Hepatoma)
05/2013 - 01/2012
2Stomach Neoplasms (Stomach Cancer)
04/2013 - 03/2010
2Exanthema (Rash)
02/2009 - 02/2007
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2004 - 03/2002
1Obesity
02/2015
1Central Nervous System Diseases (CNS Diseases)
01/2015
1Back Pain (Backache)
01/2015
1Pulmonary Embolism
01/2015
1Radiation Injuries (Radiation Sickness)
11/2014
1Testicular Neoplasms (Testicular Cancer)
02/2014
1Renal Cell Carcinoma (Grawitz Tumor)
08/2013
1Endometrial Neoplasms (Endometrial Cancer)
05/2013
1Anemia
01/2011
1Edema
01/2011

Drug/Important Bio-Agent (IBA)

26trastuzumab (Herceptin)FDA Link
05/2015 - 02/2002
10Phosphotransferases (Kinase)IBA
05/2013 - 01/2003
8DNA (Deoxyribonucleic Acid)IBA
08/2015 - 01/2005
7docetaxel (Taxotere)FDA Link
01/2014 - 05/2004
6Estrogens (Estrogen)FDA Link
02/2015 - 01/2009
5Phenobarbital (Luminal)FDA Link
02/2015 - 01/2005
5RNA (Ribonucleic Acid)IBA
02/2015 - 06/2008
5PlatinumIBA
06/2014 - 05/2004
5lapatinib (GW572016)FDA Link
01/2014 - 02/2006
5Epidermal Growth Factor Receptor (EGF Receptor)IBA
06/2013 - 12/2003
4bevacizumabFDA Link
06/2015 - 08/2010
4Paclitaxel (Taxol)FDA LinkGeneric
06/2015 - 08/2004
4Carboplatin (JM8)FDA LinkGeneric
06/2014 - 05/2004
3HormonesIBA
02/2015 - 01/2003
3Cisplatin (Platino)FDA LinkGeneric
06/2014 - 05/2004
36- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- oneIBA
08/2013 - 01/2009
3Proteins (Proteins, Gene)IBA
06/2013 - 04/2006
3Messenger RNA (mRNA)IBA
12/2010 - 02/2008
2InterferonsIBA
08/2015 - 02/2014
2TamoxifenFDA LinkGeneric
02/2015 - 04/2006
2fulvestrant (Faslodex)FDA Link
02/2015 - 03/2013
2Cyclin-Dependent Kinase 4IBA
01/2015 - 08/2013
2Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2015 - 08/2013
2Cyclin D1IBA
01/2015 - 03/2002
2Transcription Factors (Transcription Factor)IBA
06/2014 - 04/2010
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2013 - 02/2007
2Carbon MonoxideIBA
06/2013 - 04/2010
2dasatinib (BMS 354825)FDA Link
05/2013 - 11/2007
2Epidermal Growth Factor (EGF)IBA
09/2012 - 12/2004
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2012 - 03/2004
2erlotinib (CP 358,774)FDA Link
03/2010 - 02/2009
2hydrogen sulfite (bisulfite)IBA
01/2010 - 08/2005
2taxaneIBA
05/2007 - 08/2004
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2006 - 08/2004
2tyrosine receptor (receptor, tyrosine)IBA
01/2005 - 01/2003
2Complementary DNA (cDNA)IBA
01/2003 - 06/2002
1Interferon Type IIBA
08/2015
1Double-Stranded RNA (RNA, Double Stranded)IBA
08/2015
1AMG 386IBA
06/2015
1Angiopoietin-1IBA
06/2015
1LipocalinsIBA
02/2015
1exemestane (Aromasin)FDA Link
02/2015
1everolimusFDA Link
02/2015
1letrozole (Femara)FDA LinkGeneric
01/2015
1Cyclin-Dependent Kinase Inhibitor p16IBA
01/2015
1benthiocarb (Bolero)IBA
07/2014
1Insulin (Novolin)FDA Link
06/2014
1Insulin-Like Growth Factor I (IGF-1)IBA
06/2014
1AMG 479IBA
06/2014
1Insulin-Like Growth Factor II (Somatomedin A)IBA
06/2014
1pyruvate dehydrogenase (acetyl-transferring) kinase (pyruvate dehydrogenase kinase)IBA
03/2014
1Glucose (Dextrose)FDA LinkGeneric
03/2014
1Dichloroacetate (Dichloroacetic Acid)IBA
03/2014
1ChemokinesIBA
02/2014
1AntigensIBA
02/2014
1CytokinesIBA
02/2014
1aurora kinase (aurora A kinase)IBA
10/2013
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
06/2013
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2013
15- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA
06/2013
1AG 014699IBA
06/2013
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
05/2013
14- amino- 5- fluoro- 3- (5- (4- methylpiperazin- 1- yl)- 1H- benzimidazol- 2- yl)quinolin- 2(1H)- oneIBA
05/2013
1Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA
05/2013
1Estrogen Receptor Modulators (Antiestrogen)IBA
03/2013
1LigandsIBA
09/2012
1DNA topoisomerase II alphaIBA
03/2011
1AnthracyclinesIBA
03/2011

Therapy/Procedure

15Drug Therapy (Chemotherapy)
06/2014 - 07/2002
8Heterologous Transplantation (Xenotransplantation)
07/2014 - 02/2006
4Therapeutics
01/2015 - 12/2010
3Adjuvant Chemotherapy
02/2015 - 03/2006
1Immunotherapy
01/2015
1Cell Transplantation
11/2014
1Aftercare (After-Treatment)
02/2014