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Stewart Shuman Selected Research

Vaccinia

4/2014Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.
2/2013Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification.
1/2012Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain.
10/2011Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
11/2008Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site.
11/2008Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.
6/2008Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.
4/2008Structure-function analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase.
12/2007Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly.
11/2006Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase.
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Stewart Shuman Research Topics

Disease

23Vaccinia
04/2014 - 02/2002
11Infection
04/2014 - 10/2006
2Bites and Stings (Sting)
04/2014 - 08/2013
2Tuberculosis (Tuberculoses)
01/2011 - 05/2004
1Starvation
10/2015
1Hypersensitivity (Allergy)
02/2013
1Myxoma (Myxomas)
01/2012
1Poxviridae Infections
01/2012
1Contagious Ecthyma (Orf)
02/2010
1Neoplasms (Cancer)
06/2006
1Kaposi Sarcoma (Kaposi's Sarcoma)
04/2005
1Breast Neoplasms (Breast Cancer)
10/2004
1Acquired Immunodeficiency Syndrome (AIDS)
02/2002

Drug/Important Bio-Agent (IBA)

15DNA (Deoxyribonucleic Acid)IBA
04/2014 - 03/2003
9Type I DNA Topoisomerases (Topoisomerase I)IBA
02/2013 - 03/2003
7RNA (Ribonucleic Acid)IBA
01/2012 - 02/2002
3Transfer RNA (tRNA)IBA
06/2012 - 08/2007
3anticodon nucleaseIBA
06/2012 - 01/2011
3Amino AcidsFDA Link
04/2005 - 02/2002
2Adenosine Monophosphate (AMP)IBA
04/2014 - 08/2013
2Phosphotransferases (Kinase)IBA
04/2014 - 02/2002
2Z-Form DNA (Z-DNA)IBA
01/2012 - 10/2011
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2011 - 10/2006
2Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)IBA
02/2010 - 02/2002
2Interleukin-6 (Interleukin 6)IBA
11/2008 - 10/2006
2ApoenzymesIBA
11/2008 - 03/2006
2Tyrosine (L-Tyrosine)FDA Link
04/2005 - 02/2002
1Acid PhosphataseIBA
10/2015
1chenodeoxycholate sulfate conjugate (CDCS)IBA
04/2014
15'-Guanylic Acid (GMP)IBA
04/2014
1Virulence Factors (Pathogenicity Factors)IBA
04/2014
1Interferon Type IIBA
04/2014
1Cyclic GMPIBA
08/2013
15,6-dimethylxanthenoneacetic acidIBA
08/2013
1InterferonsIBA
08/2013
1LigandsIBA
08/2013
1Lysine (L-Lysine)FDA Link
02/2013
1Lys Transfer RNAIBA
01/2012
1Viral RNAIBA
01/2012
1Carbon MonoxideIBA
01/2012
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2011
1Interferon-betaIBA
11/2008
1Guanosine Triphosphate (GTP)IBA
04/2008
1Mitoxantrone (Novantrone)FDA LinkGeneric
12/2007
1Cytarabine (Cytosar-U)FDA LinkGeneric
10/2006
1Poly I-CIBA
10/2006
1Interleukin-12 (IL 12)IBA
10/2006
1adjuvant P40 (P 40)IBA
10/2006
1NF-kappaB inhibitor alphaIBA
10/2006
1Interleukin-1beta (Interleukin 1 beta)IBA
10/2006
1AntigensIBA
10/2006
1adenosine N(1)-oxideIBA
10/2006
1Interferon-alpha (Interferon Alfa)FDA Link
10/2006
1CytokinesIBA
10/2006
1Interleukin-10 (Interleukin 10)IBA
10/2006
1A-Form DNA (A-DNA)IBA
06/2006
1exodeoxyribonuclease IIIIBA
06/2006
1DNA AdductsIBA
06/2006
1MicroRNAs (MicroRNA)IBA
04/2005
1acylphosphataseIBA
10/2004
1EnzymesIBA
10/2004
1carboxy-terminal domain phosphataseIBA
10/2004
1benzo(c)phenanthreneIBA
05/2004
1NogalamycinIBA
05/2004
18-hydroxyguanineIBA
10/2003
1pyreneIBA
10/2003
12-Aminopurine (2 Aminopurine)IBA
10/2003
18-hydroxyadenineIBA
10/2003
1Basic Amino Acids (Basic Amino Acid)IBA
04/2003
1vaccinia virus capping enzymeIBA
04/2003
1Alanine (L-Alanine)FDA Link
04/2003
1Benzo(a)pyreneIBA
03/2003
1RNA triphosphataseIBA
03/2003
1A-factor (Streptomyces)IBA
02/2002
1hydroxide ionIBA
02/2002