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Yasuaki Shimizu Selected Research

Phosphodiesterase 4 Inhibitors

1/2012Therapeutic potential of ASP3258, a selective phosphodiesterase 4 inhibitor, on chronic eosinophilic airway inflammation.
6/2011ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity.
5/2011Disease-modifying effect of ASP3258, a novel phosphodiesterase type 4 inhibitor, on subchronic cigarette smoke exposure-induced lung injury in guinea pigs.
7/2006The effects of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on T-cell-related cytokine production in vitro and in vivo.

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Yasuaki Shimizu Research Topics

Disease

7Pain (Aches)
09/2014 - 01/2010
6Inflammation
06/2013 - 01/2006
6Asthma (Bronchial Asthma)
01/2012 - 01/2006
4Arthritis (Polyarthritis)
09/2014 - 03/2007
3Vomiting
01/2012 - 07/2006
3Infection
08/2010 - 02/2005
3Hypersensitivity (Allergy)
12/2008 - 01/2006
2Fibromyalgia (Fibrositis)
07/2013 - 01/2012
2Eosinophilia
01/2012 - 08/2008
2Osteoarthritis
01/2011 - 09/2010
2Rheumatoid Arthritis
12/2008 - 03/2007
2Atopic Dermatitis (Atopic Eczema)
06/2007 - 01/2006
2Rhinitis
06/2007 - 04/2006
1Obesity
07/2013
1Central Nervous System Diseases (CNS Diseases)
07/2013
1Hyperalgesia
07/2013
1Schizophrenia (Dementia Praecox)
07/2013
1Neuralgia (Stump Neuralgia)
01/2012
1Vascular System Injuries
01/2012
1Pneumonia (Pneumonitis)
01/2012
1Chronic Obstructive Pulmonary Disease (COPD)
05/2011
1Lung Injury
05/2011
1Herpes Genitalis (Genital Herpes)
01/2011
1Disease Progression
08/2010
1Autoimmune Diseases (Autoimmune Disease)
12/2008
1Autoimmune Hepatitis
12/2008
1Graft vs Host Disease (Graft-Versus-Host Disease)
12/2008
1Leukemia
01/2008
1Experimental Arthritis
03/2007
1Edema
11/2006
1Contact Dermatitis (Eczema, Contact)
11/2006
1Nausea
07/2006
1Carcinoma (Carcinomatosis)
02/2005

Drug/Important Bio-Agent (IBA)

4AntigensIBA
06/2013 - 01/2008
4Phosphodiesterase 4 InhibitorsIBA
01/2012 - 07/2006
3RoflumilastIBA
01/2012 - 06/2011
31- (2- hydroxy- 1- phenylethyl)- 3- (4- (pyridin- 4- yl)phenyl)ureaIBA
01/2011 - 01/2010
3rho-Associated KinasesIBA
01/2011 - 01/2010
3Cyclosporine (Ciclosporin)FDA LinkGeneric
12/2008 - 11/2006
3CCR3 ReceptorsIBA
06/2007 - 01/2006
3N- (4,6- dimethylpyrimidin- 2- yl)- 4- (2- (4- methoxy- 3- methylphenyl)- 5- (4- methylpiperazin- 1- yl)- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzenesulfonamide difumarateIBA
03/2007 - 07/2006
2Analgesics (Analgesic Drugs)IBA
09/2014 - 11/2012
2Reserpine (Serpasil)FDA Link
07/2013 - 01/2012
2CilomilastIBA
01/2012 - 06/2011
2DNA Primase (Primase)IBA
01/2011 - 08/2010
2valacyclovir (valaciclovir)FDA LinkGeneric
01/2011 - 08/2010
24- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilideIBA
12/2008 - 01/2008
2LigandsIBA
09/2006 - 04/2006
1SodiumIBA
09/2014
1YM348IBA
07/2013
18- chloro- 2,3,4,5- tetrahydro- 1- methyl- 1H- 3- benzazepineIBA
07/2013
15-HT2C Serotonin ReceptorIBA
07/2013
1Formyl Peptide Receptors (Formyl Peptide Receptor)IBA
06/2013
1Dihydrotachysterol (AT 10)IBA
01/2012
1Mexiletine (Mexitil)FDA LinkGeneric
01/2012
1Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
01/2012
1OvalbuminIBA
01/2012
1Biogenic Amines (Biogenic Amine)IBA
01/2012
1Prednisolone (Predate)FDA LinkGeneric
01/2012
1SmokeIBA
05/2011
1BradykininIBA
01/2011
1Acyclovir (Aciclovir)FDA LinkGeneric
01/2011
1Urea (Carbamide)FDA LinkGeneric
09/2010
1Streptozocin (Streptozotocin)FDA Link
01/2010
12- ((4- morpholin- 4- ylphenyl)amino)- 4- ((2,3,6- trifluorobenzyl)amino)pyrimidine- 5- carboxamideIBA
08/2008
1Immunoglobulin E (IgE)IBA
01/2008
1LeukotrienesIBA
01/2008
1N- (1- ((6- fluoro- 2- naphthyl)methyl)pyrrolidin- 3- yl)- 2- (1- ((6- methylpyridazin- 3- yl)carbonyl)piperidin- 4- ylidene)acetamideIBA
06/2007
1ChemokinesIBA
06/2007
1Histamine H1 Receptors (Histamine H1 Receptor)IBA
06/2007
1Histamine (Histamine Dihydrochloride)FDA Link
06/2007
1Type 7 Cyclic Nucleotide PhosphodiesterasesIBA
03/2007
1ZymosanIBA
11/2006
1CarrageenanIBA
11/2006
1Chemokine CCL5IBA
09/2006
1CCR5 Receptors (CCR5 Receptor)IBA
09/2006
1YM 976IBA
07/2006
1Chemokine CCL24IBA
04/2006
1Chemokine CCL11IBA
01/2006
1N- (1- ((6- fluoro- 2- naphthyl)methyl)pyrrolidin- 3- yl)- 2- (1- ((3- methyl- 1- oxidopyridin- 2- yl)carbonyl)piperidin- 4- ylidene)acetamideIBA
01/2006
1Antiviral Agents (Antivirals)IBA
02/2005
1diphenyl (biphenyl)IBA
02/2005
16-(4-((biphenyl-2-ylcarbonyl) amino)benzoyl)1- N- cyclopropyl- 5,6- dihydro- 4H- thieno(3,2- d)(1)benzazepine- 2- carboxamideIBA
02/2005

Therapy/Procedure

1Intra-Articular Injections
09/2014
1Drug Therapy (Chemotherapy)
01/2012
1Anesthesia
06/2011
1Aftercare (After-Treatment)
01/2011