Tomoharu Shimizu Selected Research

Hemorrhage

07/2008	The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells.
09/2007	Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage.
06/2007	Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alpha.
06/2007	The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage.
03/2007	Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway.
02/2007	Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.
01/2007	17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage.
01/2007	Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage.
08/2006	17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha.
08/2006	Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis.
07/2006	A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage.
06/2006	Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage.
05/2006	Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage.
05/2006	Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage.
04/2006	Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis.
03/2006	Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression.
02/2006	Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
08/2005	Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma.
07/2005	Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase.
05/2005	Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1.
02/2005	Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase.
08/2004	Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage.

Articles by Research Topic

Disease

23	Wounds and Injuries (Trauma) 07/2008 - 08/2004
22	Hemorrhage 07/2008 - 08/2004
5	Hemorrhagic Shock 01/2008 - 01/2002
5	Sepsis (Septicemia) 12/2006 - 03/2006
1	Syndrome 10/2006
1	Shock 01/2006
1	Hepatic Insufficiency 12/2002

Drug/Important Bio-Agent (IBA)

7	AndrostenediolIBA 03/2007 - 08/2004
4	Estrogens (Estrogen)FDA Link 07/2008 - 01/2007
4	Estrogen Receptor betaIBA 06/2006 - 01/2006
3	Estrogen Receptor alphaIBA 09/2007 - 08/2006
3	Estradiol (Estrace)FDA LinkGeneric 08/2006 - 07/2005
2	phenylmethylpyrazoloneIBA 01/2008 - 05/2005
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/2007 - 02/2005
2	Flutamide (Eulexin)FDA LinkGeneric 02/2007 - 02/2006
2	Endothelin-1 (Endothelin 1)IBA 01/2007 - 05/2005
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2006 - 01/2006
1	capsazepineIBA 06/2007
1	Caspase 3 (Caspase-3)IBA 03/2007
1	AdiponectinIBA 08/2006
1	PPAR gammaIBA 07/2006
1	Estrogen ReceptorsIBA 05/2006
1	Peroxidase (Myeloperoxidase)IBA 02/2006
1	Peroxisome ProliferatorsIBA 08/2005
1	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 07/2005
1	Peptidoglycan (Murein)IBA 01/2002

Therapy/Procedure

2	Blood Component Removal (Apheresis) 12/2006 - 03/2006
1	Resuscitation 01/2008
1	Renal Dialysis (Hemodialysis) 10/2006
1	Liver Transplantation 12/2002
1	Plasmapheresis 12/2002