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Takao Shimizu Selected Research

Leukotriene B4

1/2015The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.
8/2013Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.
5/2012Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway.
9/2008Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis.
7/2008Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin.
2/2007Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation.
10/2005Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses.
9/2005Leukotriene B4 receptor and the function of its helix 8.
8/2002Leukotriene B4 receptors.

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Takao Shimizu Research Topics

Disease

23Inflammation
02/2015 - 05/2002
6Pain (Aches)
01/2015 - 07/2004
6Hypersensitivity (Allergy)
03/2012 - 10/2005
6Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
04/2010 - 09/2005
5Neoplasms (Cancer)
01/2014 - 02/2003
4Bone Resorption
12/2009 - 05/2003
4Asthma (Bronchial Asthma)
12/2009 - 01/2002
3Obesity
02/2015 - 06/2003
3Hemorrhage
11/2013 - 08/2002
3Ischemia
08/2013 - 06/2003
3Reperfusion Injury
08/2013 - 06/2003
3Fibrosis (Cirrhosis)
10/2012 - 05/2006
3Anaphylaxis (Anaphylactic Shock)
03/2012 - 04/2008
3Multiple Sclerosis
12/2009 - 10/2008
3Infection
01/2006 - 07/2003
2Insulin Resistance
04/2010 - 06/2003
2Pulmonary Fibrosis (Hamman Rich Syndrome)
12/2009 - 05/2002
2Idiopathic Pulmonary Fibrosis
12/2009 - 05/2002
2Osteoporosis
03/2008 - 07/2004
2Pneumococcal Pneumonia
01/2006 - 02/2004
2Lissencephaly
11/2005 - 08/2003
1Fever (Fevers)
01/2015
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2014
1Pathologic Constriction (Stenosis)
11/2014
1Acute Lung Injury
08/2014
1Wounds and Injuries (Trauma)
06/2014
1Psoriasis (Pustulosis Palmaris et Plantaris)
05/2014
1Hydronephrosis
01/2014
1False Aneurysm (Pseudoaneurysm)
11/2013
1Rupture
11/2013
1Parkinson Disease (Parkinson's Disease)
09/2013
1Atrophy
05/2013
1Autoimmune Diseases (Autoimmune Disease)
01/2013
1Neoplasm Metastasis (Metastasis)
11/2012
1Pneumothorax
11/2012
1Breast Neoplasms (Breast Cancer)
11/2012
1Ulcer
11/2012
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2012
1Myocardial Infarction
05/2012
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
01/2012

Drug/Important Bio-Agent (IBA)

13Phospholipases (Phospholipase)IBA
01/2015 - 05/2002
12platelet activating factor receptorIBA
09/2013 - 03/2002
11Platelet Activating FactorIBA
02/2015 - 01/2002
9Leukotriene B4IBA
01/2015 - 08/2002
6Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA
01/2015 - 10/2005
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 06/2003
5EnzymesIBA
07/2010 - 06/2004
4CytokinesIBA
05/2014 - 05/2003
4Arachidonic Acid (Vitamin F)IBA
10/2012 - 07/2010
4EicosanoidsIBA
12/2011 - 05/2002
4GTP-Binding Proteins (G-Protein)IBA
10/2010 - 07/2003
4Prostaglandins E (PGE)IBA
07/2010 - 05/2003
3Dinoprostone (PGE2)FDA Link
01/2015 - 05/2003
3Group IV Phospholipases A2IBA
10/2012 - 09/2005
3Immunoglobulin G (IgG)IBA
03/2012 - 04/2008
3CollagenIBA
12/2009 - 05/2002
2Formaldehyde (Formol)FDA Link
01/2015 - 09/2007
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
06/2014 - 02/2010
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2014 - 02/2010
2prostaglandin-E synthaseIBA
01/2014 - 12/2009
2Proteins (Proteins, Gene)IBA
10/2012 - 12/2009
2IgG Receptors (Fc gamma RI)IBA
03/2012 - 04/2011
2Immunoglobulin E (IgE)IBA
03/2012 - 04/2008
2Phospholipases A2 (Phospholipase A2)IBA
12/2011 - 05/2003
2Small Interfering RNA (siRNA)IBA
10/2010 - 07/2010
2AdiponectinIBA
04/2010 - 06/2003
2Bleomycin (Blenoxane)FDA LinkGeneric
12/2009 - 05/2002
2indium-bleomycinIBA
12/2009 - 05/2002
2modipafantIBA
06/2003 - 03/2002
1Messenger RNA (mRNA)IBA
02/2015
1Lipoprotein Lipase (Diacylglycerol Lipase)IBA
01/2015
1Lipase (Acid Lipase)FDA Link
01/2015
1LipopolysaccharidesIBA
01/2015
1CB1 Cannabinoid Receptor (CB1 Receptor)IBA
01/2015
1Endocannabinoids (Endocannabinoid)IBA
01/2015
12-arachidonylglycerol (2-arachidonoylglycerol)IBA
01/2015
1Pulmonary Surfactants (Pulmonary Surfactant)IBA
08/2014
1lipoxin A4IBA
08/2014
1Matrix MetalloproteinasesIBA
06/2014
112-hydroxy-5,8,10-heptadecatrienoic acidIBA
06/2014
1ChemokinesIBA
05/2014
1imiquimod (Aldara)FDA LinkGeneric
05/2014
1LipidsIBA
05/2014
1ThrombospondinsIBA
01/2014
1Chromogranin AIBA
01/2014
1Tetrachlorodibenzodioxin (TCDD)IBA
01/2014
1Indomethacin (Indometacin)FDA LinkGeneric
05/2013
1AntigensIBA
01/2013
1Carbon Tetrachloride (Tetrachloromethane)IBA
10/2012
12,5-dichloro-4-bromophenol (B 2)IBA
05/2012
1IgE Receptors (Fc epsilon RI)IBA
03/2012

Therapy/Procedure

3Pancreaticoduodenectomy
11/2014 - 11/2013
2Drug Therapy (Chemotherapy)
11/2012 - 04/2005
2Ovariectomy (Oophorectomy)
12/2009 - 07/2004
1Injections
01/2015
1Stents
11/2014
1Pancreatectomy
11/2013
1Mastectomy (Mammectomy)
11/2012
1Lymph Node Excision (Lymph Node Dissection)
11/2012
1Chest Tubes (Chest Tube)
11/2012