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John W Semple Selected Research

RHO(D) antibody (anti-D)

8/2011Management of immune thrombocytopenic purpura in children: potential role of novel agents.
11/2007Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells.
10/2003Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist.

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John W Semple Research Topics

Disease

17Thrombocytopenia (Thrombopenia)
12/2015 - 01/2006
11Hemorrhage
09/2012 - 01/2003
7Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
05/2008 - 01/2003
3Inflammation
12/2015 - 08/2012
3Infection
12/2015 - 06/2007
3Thrombocytopenic Purpura (Thrombopenic Purpura)
08/2011 - 10/2003
2Acute Lung Injury
12/2015 - 01/2012
2Pulmonary Edema
05/2014 - 10/2010
2Autoimmune Diseases (Autoimmune Disease)
10/2013 - 01/2003
2Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
01/2013 - 07/2005
1Genetic Predisposition to Disease (Genetic Predisposition)
04/2014
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2013
1Vascular Diseases (Vascular Disease)
08/2012
1Shock
01/2012
1Dyspnea (Shortness of Breath)
01/2012
1Nausea
08/2011
1Vomiting
08/2011
1Headache (Headaches)
08/2011
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
10/2010
1Hypothermia
10/2010
1Tetanus
09/2010
1von Willebrand Diseases (von Willebrand's Disease)
05/2008
1Hemophilia A (Haemophilia)
05/2008
1Hemophilia B (Haemophilia B)
05/2008
1Neonatal Alloimmune Thrombocytopenia
04/2006
1Postoperative Hemorrhage
06/2005
1Weight Loss (Weight Reduction)
02/2004

Drug/Important Bio-Agent (IBA)

13Inosine Triphosphate (ITP)IBA
04/2014 - 04/2006
5AntibodiesIBA
12/2015 - 06/2005
5AntigensIBA
12/2015 - 01/2003
5Fc Receptors (Fc Receptor)IBA
09/2012 - 01/2003
5Immunoglobulins (Immunoglobulin)IBA
01/2012 - 02/2004
4Intravenous Immunoglobulins (IVIG)FDA Link
01/2012 - 04/2006
4Immunoglobulin G (IgG)IBA
10/2010 - 04/2006
4AutoantibodiesIBA
07/2005 - 01/2003
3RHO(D) antibody (anti-D)IBA
08/2011 - 10/2003
2Toll-Like Receptors (Toll-Like Receptor)IBA
08/2012 - 01/2006
2ThrombinFDA Link
05/2008 - 06/2005
1C-Reactive ProteinIBA
12/2015
1Acute-Phase Proteins (Acute-Phase Protein)IBA
12/2015
1Phospholipases A2 (Phospholipase A2)IBA
10/2014
1Chemokine CXCL2IBA
05/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2012
1rituximab (Mabthera)FDA Link
08/2011
1Thrombopoietin ReceptorsIBA
08/2011
1GlucocorticoidsIBA
08/2011
1Muramidase (Lysozyme)IBA
09/2010
1Diphtheria-Tetanus VaccineIBA
09/2010
1gamma-Globulins (gamma-Globulin)IBA
02/2010
1Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
05/2008
1Factor IX (PTC)FDA LinkGeneric
05/2008
1FibrinIBA
05/2008
1Factor VIII (Coagulation Factor VIII)IBA
05/2008
1Rho(D) Immune Globulin (RhoGAM)IBA
08/2007
1Indicators and Reagents (Reagents)IBA
08/2007
1Bacterial AntibodiesIBA
06/2007
1Toll-Like Receptor 4IBA
06/2007
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2007
1Platelet Membrane Glycoprotein IIbIBA
04/2006
1Integrin beta3 (GPIIIa)IBA
04/2006
1Caspase 3 (Caspase-3)IBA
04/2006
1Glycoproteins (Glycoprotein)IBA
04/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2006
1Factor V (Coagulation Factor V)IBA
06/2005
1CytokinesIBA
10/2003

Therapy/Procedure

1Blood Transfusion (Blood Transfusions)
12/2015
1Platelet Transfusion (Blood Platelet Transfusions)
01/2014
1Intravenous Injections
10/2010
1Injections
10/2010
1Induced Hypothermia
10/2010
1Immunotherapy
01/2003