Martin G Schwacha Selected Research

Hemorrhage

10/2008	Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
10/2008	Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels.
08/2008	The role of MIP-1alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage.
08/2008	Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.
08/2008	Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
06/2008	p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
06/2008	Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1.
03/2008	Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process.
01/2008	17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha.
10/2007	Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.
09/2007	Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.
07/2007	17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage.
06/2007	The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.
06/2007	Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.
05/2007	Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage.
05/2007	Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.
04/2007	G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.
03/2007	The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage.
03/2007	Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production.
03/2007	17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage.
01/2007	Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage.
01/2007	17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage.
11/2006	Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice.
09/2006	Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage.
08/2006	Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis.
05/2006	Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage.
05/2006	Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage.
03/2006	Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression.
02/2006	Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
01/2006	Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
07/2005	Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase.
02/2005	Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase.
09/2004	Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage.
06/2004	Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage.
05/2004	The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage.
12/2003	Upregulation of hepatic prolactin receptor gene expression by 17beta-estradiol following trauma-hemorrhage.
04/2003	Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis.
03/2003	Immunoprotection in proestrus females following trauma-hemorrhage: the pivotal role of estrogen receptors.
04/2002	Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage.
01/2002	Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis.

Articles by Research Topic

Disease

43	Wounds and Injuries (Trauma) 10/2008 - 01/2002
40	Hemorrhage 10/2008 - 01/2002
3	Poisoning 05/2008 - 08/2006
3	Burns 05/2008 - 07/2006
3	Sepsis (Septicemia) 08/2006 - 01/2002
2	Anoxia (Hypoxia) 09/2006 - 05/2002
2	Hemorrhagic Shock 12/2004 - 12/2003

Drug/Important Bio-Agent (IBA)

13	Estrogens (Estrogen)FDA Link 10/2008 - 05/2002
6	Estradiol (Estrace)FDA LinkGeneric 06/2008 - 04/2003
4	p38 Mitogen-Activated Protein KinasesIBA 06/2008 - 09/2006
3	Flutamide (Eulexin)FDA LinkGeneric 08/2008 - 01/2006
3	Estrogen Receptor betaIBA 09/2006 - 02/2006
2	Protein Kinases (Protein Kinase)IBA 03/2008 - 06/2007
2	Peroxidase (Myeloperoxidase)IBA 09/2007 - 02/2006
2	Endothelin-1 (Endothelin 1)IBA 01/2007 - 09/2004
2	Interleukin-6 (Interleukin 6)IBA 09/2006 - 12/2004
2	AndrostenediolIBA 08/2006 - 02/2005
2	Estrogen ReceptorsIBA 05/2006 - 03/2003
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 07/2005 - 12/2003
2	Interleukin-10 (Interleukin 10)IBA 06/2004 - 05/2004
2	Prolactin Receptors (Prolactin Receptor)IBA 12/2003 - 05/2002
2	Gonadal Steroid Hormones (Sex Hormones)IBA 04/2002 - 01/2002
1	GlycogenIBA 10/2008
1	Chemokine CCL3IBA 08/2008
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 08/2008
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 08/2008
1	neutrophil cytosol factor 67KIBA 05/2008
1	Heme Oxygenase-1IBA 05/2008
1	Protein Tyrosine PhosphatasesIBA 05/2008
1	Estrogen Receptor alphaIBA 01/2008
1	Mitogen-Activated Protein KinasesIBA 07/2007
1	Adenosine Triphosphate (ATP)IBA 05/2007
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 04/2007
1	GTP-Binding Proteins (G-Protein)IBA 04/2007
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2007
1	Toll-Like Receptors (Toll-Like Receptor)IBA 03/2007
1	Lidocaine (Xylocaine)FDA LinkGeneric 11/2006
1	src-Family KinasesIBA 09/2006
1	Interleukin-18 (Interleukin 18)IBA 08/2006
1	CorticosteroneIBA 08/2006
1	Analgesics (Analgesic Drugs)IBA 07/2006
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2006
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 02/2005

Therapy/Procedure

1	Resuscitation 10/2008