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Paul T Schumacker Selected Research

Reactive Oxygen Species (Oxygen Radicals)

8/2015Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent.
2/2015Reactive oxygen species in cancer: a dance with the devil.
1/2015Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn.
6/2014Mitochondria in lung biology and pathology: more than just a powerhouse.
12/2013Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling.
12/2013Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.
8/2013Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung.
8/2012Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.
11/2011Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses.
9/2011Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
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Paul T Schumacker Research Topics

Disease

34Anoxia (Hypoxia)
06/2014 - 03/2002
8Pulmonary Hypertension (Ayerza Syndrome)
09/2015 - 02/2008
8Hyperoxia
08/2015 - 02/2008
7Ischemia
04/2013 - 03/2002
5Neoplasms (Cancer)
02/2015 - 09/2006
2Fibrosis (Cirrhosis)
01/2015 - 04/2011
2Parkinson Disease (Parkinson's Disease)
04/2013 - 12/2010
2Lymphoma (Lymphomas)
01/2013 - 05/2008
2Reperfusion Injury
06/2007 - 01/2003
1Bronchopulmonary Dysplasia
08/2015
1Pulmonary Fibrosis (Hamman Rich Syndrome)
01/2015
1Asbestosis
01/2015
1Wounds and Injuries (Trauma)
06/2014
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2013
1Rupture
04/2013
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
01/2013
1Hyperglycemia
02/2012
1Lung Injury
04/2011
1Hypercapnia
02/2008

Drug/Important Bio-Agent (IBA)

31Reactive Oxygen Species (Oxygen Radicals)IBA
08/2015 - 03/2002
10OxygenIBA
08/2015 - 01/2003
7CalciumIBA
04/2013 - 10/2002
6Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA
02/2013 - 03/2002
6CatalaseIBA
08/2012 - 10/2002
5Phosphotransferases (Kinase)IBA
09/2011 - 06/2002
5AntioxidantsIBA
07/2011 - 10/2002
4Transcription Factors (Transcription Factor)IBA
11/2013 - 09/2006
4Superoxides (Superoxide)IBA
02/2013 - 06/2002
4Superoxide DismutaseIBA
08/2012 - 10/2006
3NADPH Oxidase (NAD(P)H oxidase)IBA
07/2015 - 04/2002
3Mitochondrial DNA (mtDNA)IBA
01/2015 - 09/2007
3Adenosine Triphosphate (ATP)IBA
04/2013 - 02/2007
3Adenosine Triphosphatases (ATPase)IBA
11/2011 - 02/2007
3Proteins (Proteins, Gene)IBA
04/2011 - 03/2009
3myxothiazolIBA
10/2006 - 06/2002
2Carbon MonoxideIBA
09/2015 - 02/2008
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
05/2013 - 09/2011
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
04/2013 - 07/2011
2mitochondrial permeability transition poreIBA
04/2013 - 04/2011
2Protein Kinases (Protein Kinase)IBA
08/2012 - 11/2011
2Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
08/2012 - 02/2008
2Adenosine Monophosphate (AMP)IBA
11/2011 - 09/2011
2Small Interfering RNA (siRNA)IBA
09/2011 - 03/2009
2Cysteine (L-Cysteine)FDA Link
02/2008 - 06/2002
2Rieske iron-sulfur proteinIBA
09/2007 - 06/2005
2Antimycin AIBA
10/2002 - 03/2002
2diphenyleneiodoniumIBA
10/2002 - 04/2002
2RotenoneIBA
10/2002 - 04/2002
1MicroRNAs (MicroRNA)IBA
09/2015
1CollagenIBA
01/2015
1Caspase 3 (Caspase-3)IBA
01/2015
1Crocidolite Asbestos (Blue Asbestos)IBA
01/2015
18-hydroxyguanineIBA
01/2015
1AsbestosIBA
01/2015
1Collagen Type I (Type I Collagen)IBA
01/2015
1DNA Glycosylases (DNA Glycosylase)IBA
01/2015
1titanium dioxide (Titania)FDA Link
01/2015
1Amphibole AsbestosIBA
01/2015
1TamoxifenFDA LinkGeneric
02/2014
1Sirtuin 3IBA
12/2013
1NAD (NADH)IBA
12/2013
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
05/2013
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
04/2013
1Chloroquine (Aralen)FDA LinkGeneric
01/2013
1Histone Deacetylase InhibitorsIBA
01/2013
1AdenineFDA LinkGeneric
01/2013
1CRA 024781IBA
01/2013
1Dynamins (Dynamin)IBA
02/2012
1Calcium Channels (Calcium Channel)IBA
09/2011
1L-Type Calcium Channels (Dihydropyridine Receptor)IBA
09/2011
1Calmodulin (Calcium-Dependent Activator Protein)IBA
09/2011
1Cytochromes c (Cytochrome c)IBA
07/2011
1fluorexon (calcein)IBA
07/2011
1cyclophilin DIBA
04/2011
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2011
1Proline (L-Proline)FDA Link
11/2010
1Lysine (L-Lysine)FDA Link
11/2010
1terpestacinIBA
04/2010
1EUK-134IBA
03/2010
1Glucose (Dextrose)FDA LinkGeneric
09/2009
1ThioredoxinsIBA
05/2008
1Adrenergic beta-Agonists (beta-Adrenergic Agonists)IBA
02/2008
1Isoproterenol (Isoprenaline)FDA LinkGeneric
02/2008
1sildenafil (Viagra)FDA Link
02/2008
1UbiquinoneIBA
09/2007
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2007
1Glutathione (Reduced Glutathione)IBA
06/2007
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2007
1Ouabain (G Strophanthin)IBA
02/2007
1pyrrolidine dithiocarbamic acidIBA
10/2006
1Acetylcysteine (Siran)FDA LinkGeneric
10/2006
1Glutathione PeroxidaseIBA
10/2006
1coenzyme Q10 (CoQ10)IBA
09/2006
1Oxidants (Oxidizing Agents)IBA
09/2006
1Conditioned Culture MediaIBA
09/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2005
1SYTOX GreenIBA
02/2003
1proanthocyanidinIBA
01/2003
1Fura-2 (Fura 2)IBA
10/2002
1PD 98059IBA
06/2002