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Paula Schaiquevich Selected Research

Topotecan (Hycamtin)

10/2015Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma.
9/2014Ocular pharmacology of topotecan and its activity in retinoblastoma.
4/2014Clinical pharmacokinetics of intra-arterial melphalan and topotecan combination in patients with retinoblastoma.
5/2013Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma.
3/2013Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma.
1/2012Pharmacokinetic analysis of melphalan after superselective ophthalmic artery infusion in preclinical models and retinoblastoma patients.
1/2011Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma.
7/2010Pharmacokinetic analysis of topotecan after intra-vitreal injection. Implications for retinoblastoma treatment.
7/2009Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.
1/2008Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma.
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Paula Schaiquevich Research Topics

Disease

16Neoplasms (Cancer)
09/2015 - 11/2007
12Retinoblastoma (Glioblastoma, Retinal)
10/2015 - 07/2010
4Neutropenia
04/2014 - 01/2008
3Brain Neoplasms (Brain Tumor)
09/2013 - 09/2010
3Diarrhea
09/2010 - 01/2009
2Neuroblastoma
09/2015 - 01/2008
2Glioma (Gliomas)
09/2013 - 01/2009
2Ependymoma
09/2013 - 09/2010
2Medulloblastoma
09/2013 - 06/2009
2Exanthema (Rash)
09/2010 - 01/2009
2Thrombocytopenia (Thrombopenia)
08/2010 - 01/2008
1Body Weight (Weight, Body)
04/2014
1Uveitis
01/2013
1Fatigue
09/2010
1Leukemia
08/2010
1Hypertriglyceridemia
08/2010
1Anorexia
08/2010
1Glioblastoma (Glioblastoma Multiforme)
01/2010
1Breast Neoplasms (Breast Cancer)
10/2009
1Abdominal Pain (Pain, Abdominal)
04/2009
1Colitis
04/2009
1Hypokalemia
04/2009
1Headache (Headaches)
04/2009
1Pruritus (Itching)
01/2009

Drug/Important Bio-Agent (IBA)

11Topotecan (Hycamtin)FDA LinkGeneric
10/2015 - 11/2007
4Melphalan (Alkeran)FDA LinkGeneric
11/2014 - 01/2012
4lapatinib (GW572016)FDA Link
09/2013 - 10/2009
2irinotecan (Camptosar)FDA LinkGeneric
09/2015 - 04/2009
2Retinaldehyde (Retinal)IBA
09/2014 - 03/2013
2Carboplatin (JM8)FDA LinkGeneric
05/2014 - 01/2011
2oxaliplatin (Eloxatin)FDA LinkGeneric
09/2010 - 04/2009
2Lipase (Acid Lipase)FDA Link
04/2009 - 01/2009
1Digoxin (Digitek)FDA LinkGeneric
07/2015
1Proteins (Proteins, Gene)IBA
09/2013
1First StepIBA
01/2013
1lenalidomide (CC 5013)FDA Link
01/2011
19 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA
01/2011
1vorinostat (suberoylanilide hydroxamic acid)FDA Link
08/2010
1Tretinoin (Retinoic Acid)FDA LinkGeneric
08/2010
1epidermal growth factor receptor VIIIIBA
01/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2009
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2009
1EnzymesIBA
04/2009
1AmylasesFDA Link
04/2009
1erlotinib (CP 358,774)FDA Link
01/2009
1Phosphotransferases (Kinase)IBA
01/2009
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2009
1OSI-420IBA
01/2009

Therapy/Procedure

4Intravitreal Injections
10/2015 - 09/2014
3Drug Therapy (Chemotherapy)
05/2014 - 01/2011
3Radiotherapy
05/2014 - 01/2009
2Intraocular Injections
10/2015 - 05/2013
2Injections
10/2015 - 03/2013
2Heterologous Transplantation (Xenotransplantation)
09/2015 - 01/2011
1Therapeutics
01/2013