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Daniela Salvemini Selected Research

Peroxynitrous Acid (Peroxynitrite)

12/2014A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
11/2013Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
7/2013Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance.
8/2012Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
5/2012Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.
5/2012Anti-superoxide and anti-peroxynitrite strategies in pain suppression.
1/2012Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain.
12/2011Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.
9/2011Roles of reactive oxygen and nitrogen species in pain.
6/2011Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome.
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Daniela Salvemini Research Topics

Disease

27Pain (Aches)
10/2015 - 06/2004
18Hyperalgesia
02/2015 - 06/2004
16Inflammation
04/2013 - 05/2002
13Neuralgia (Stump Neuralgia)
09/2015 - 12/2011
8Shock
02/2009 - 11/2002
6Peripheral Nervous System Diseases (PNS Diseases)
02/2015 - 05/2012
4Hypersensitivity (Allergy)
02/2015 - 09/2008
4Neoplasms (Cancer)
06/2014 - 06/2003
4Edema
01/2013 - 06/2004
4Hypotension (Low Blood Pressure)
06/2011 - 01/2003
4Ischemia
10/2008 - 06/2002
4Reperfusion Injury
10/2008 - 07/2002
3Wounds and Injuries (Trauma)
05/2012 - 07/2009
3Body Weight (Weight, Body)
02/2009 - 06/2003
3Necrosis
09/2004 - 05/2002
3Septic Shock (Toxic Shock Syndrome)
01/2003 - 11/2002
2Melanoma (Melanoma, Malignant)
06/2011 - 06/2003
2Experimental Arthritis
12/2005 - 06/2005
2Heart Failure
01/2005 - 07/2002
2Atherosclerosis
10/2004 - 07/2003
2Sepsis (Septicemia)
10/2004 - 01/2003
1Multiple Sclerosis
07/2014

Drug/Important Bio-Agent (IBA)

30Peroxynitrous Acid (Peroxynitrite)IBA
12/2014 - 06/2002
27Superoxides (Superoxide)IBA
12/2014 - 05/2002
22Superoxide DismutaseIBA
11/2013 - 06/2002
11M 40403IBA
05/2008 - 05/2002
9CarrageenanIBA
01/2013 - 06/2004
8Morphine (MS Contin)FDA LinkGeneric
10/2015 - 04/2009
8Purinergic P1 Receptors (Adenosine Receptor)IBA
09/2015 - 05/2012
73-nitrotyrosineIBA
08/2012 - 08/2002
7Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2012 - 06/2002
7EnzymesIBA
04/2010 - 06/2002
7Reactive Oxygen Species (Oxygen Radicals)IBA
08/2005 - 06/2002
5Paclitaxel (Taxol)FDA LinkGeneric
12/2014 - 05/2012
5M40401IBA
10/2004 - 01/2003
5tebufenozide (Mimic)IBA
05/2004 - 06/2002
4Analgesics (Analgesic Drugs)IBA
10/2015 - 09/2009
4N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosineIBA
04/2015 - 05/2012
4AdenosineFDA LinkGeneric
04/2015 - 01/2003
4oxaliplatin (Eloxatin)FDA LinkGeneric
02/2015 - 05/2012
4CytokinesIBA
02/2015 - 02/2005
4NADPH Oxidase (NAD(P)H oxidase)IBA
12/2014 - 07/2003
4Lysosphingolipid ReceptorsIBA
07/2014 - 03/2011
4Narcotics (Narcotic Analgesics)IBA
02/2013 - 06/2004
4sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
02/2013 - 03/2011
4N-Methylaspartate (NMDA)IBA
01/2013 - 05/2002
4AnionsIBA
09/2004 - 05/2002
3Interleukin-2 (IL2)IBA
06/2011 - 06/2003
3dihydroceramide desaturaseIBA
02/2009 - 02/2008
3LigasesIBA
11/2002 - 06/2002
2Opioid Analgesics (Opioids)IBA
10/2015 - 09/2009
2Purinergic P1 Receptor AgonistsIBA
02/2015 - 12/2014
2taxaneIBA
12/2014 - 05/2012
2fingolimod (FTY720)FDA Link
07/2014 - 01/2013
2Transcription Factors (Transcription Factor)IBA
07/2014 - 08/2004
2PlatinumIBA
11/2013 - 05/2012
2bortezomib (Velcade)FDA Link
11/2013 - 05/2012
2Proteasome Endopeptidase Complex (Proteasome)IBA
11/2013 - 05/2012
2ManganeseIBA
07/2013 - 06/2004
2Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2013 - 06/2004
2OxygenIBA
09/2011 - 10/2010
2NitrogenIBA
09/2011 - 10/2010
2Prostaglandins E (PGE)IBA
08/2011 - 09/2008
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
08/2011 - 09/2008
2N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA
08/2011 - 09/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2011 - 02/2005
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
06/2011 - 05/2008
2acetovanillone (apocynin)IBA
03/2011 - 10/2010
2manganese tetrakis-(N-ethyl-2 pyridyl) porphyrinIBA
07/2009 - 01/2009
2fumonisin B1IBA
02/2009 - 10/2008
2ZymosanIBA
02/2009 - 01/2004
2OvalbuminIBA
02/2008 - 08/2005
2Malondialdehyde (Propanedial)IBA
10/2004 - 06/2003
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
09/2004 - 06/2004
2NF-kappa B (NF-kB)IBA
08/2004 - 05/2002
2CatecholaminesIBA
06/2003 - 01/2003
2Adenosine Diphosphate (ADP)IBA
11/2002 - 06/2002
1Opium (Papaveretum)IBA
10/2015
1gamma-Aminobutyric Acid (GABA)IBA
04/2015
1Interleukin-10 (Interleukin 10)IBA
02/2015
1Interleukin-4 (Interleukin 4)IBA
02/2015
1Adenosine KinaseIBA
01/2015
1Adenosine A3 ReceptorIBA
01/2015
1SphingolipidsIBA
07/2014
1Dichlorodiphenyldichloroethane (DDD)IBA
07/2014
1Freund's AdjuvantIBA
07/2014
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
06/2014
1Viral ProteinsIBA
06/2014
1Glucose (Dextrose)FDA LinkGeneric
06/2014
1Electron Transport Complex I (NADH-CoQ Reductase)IBA
11/2013
1TaxoidsIBA
11/2013
1Adenosine Triphosphate (ATP)IBA
11/2013
1Vinca AlkaloidsIBA
11/2013
1NucleosidesIBA
07/2013

Therapy/Procedure

6Drug Therapy (Chemotherapy)
02/2015 - 05/2012
4Therapeutics
01/2015 - 10/2008
2Oral Administration
09/2015 - 12/2011
2Analgesia
04/2015 - 09/2008
2Intraperitoneal Injections
09/2008 - 09/2004
1Ligation
07/2014