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Takeshi Sakurai Selected Research

Sleep Disorders

10/2013Orexin deficiency and narcolepsy.
2/2013Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status.
8/2011Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal.
1/2008Orexins and orexin receptors: from molecules to integrative physiology.
8/2004Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.

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Takeshi Sakurai Research Topics

Disease

35Narcolepsy
06/2015 - 12/2002
13Cataplexy
06/2015 - 03/2004
6Obesity
09/2013 - 06/2005
6Myocardial Infarction
06/2011 - 01/2002
5Schizophrenia (Dementia Praecox)
11/2015 - 09/2005
5Insulin Resistance
02/2015 - 07/2002
5Sleep Disorders
10/2013 - 08/2004
5Thrombosis (Thrombus)
07/2011 - 02/2006
4Substance-Related Disorders (Drug Abuse)
08/2011 - 07/2006
4Acute Coronary Syndrome
06/2011 - 09/2010
4Coronary Artery Disease (Coronary Atherosclerosis)
01/2011 - 07/2002
3Sleep Initiation and Maintenance Disorders (Insomnia)
06/2015 - 08/2011
3Body Weight (Weight, Body)
09/2014 - 09/2006
3Sleep Deprivation
11/2008 - 07/2006
2Fever (Fevers)
11/2013 - 11/2010
2Hyperphagia
09/2013 - 05/2003
2Necrosis
03/2013 - 06/2010
2Pain (Aches)
01/2013 - 01/2008
2Autistic Disorder (Autism)
08/2012 - 05/2009
2Pervasive Child Development Disorders
01/2011 - 05/2010
2Angina Pectoris
01/2010 - 07/2002
2Coronary Stenosis (Coronary Artery Stenosis)
01/2010 - 10/2002
1Postoperative Pain
01/2015
1Goiter
01/2015
1Tobacco Use Disorder (Nicotine Dependence)
01/2015
1Glucose Intolerance
06/2013
1Hyperinsulinism (Hyperinsulinemia)
06/2013
1Brain Injuries (Brain Injury)
03/2013
1Infection
03/2013
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
03/2013
1Brain Neoplasms (Brain Tumor)
03/2013
1Inflammation
03/2013
1Brain Ischemia (Cerebral Ischemia)
03/2013
1Epilepsy (Aura)
08/2012
1Nervous System Diseases (Neurological Disorders)
08/2012
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
01/2012
1Unstable Angina
07/2011
1Coronary Occlusion
06/2011
1Paralysis (Palsy)
04/2011
1Spasm (Spasms)
06/2010
1Acute Kidney Injury (Acute Renal Failure)
03/2010
1Hereditary Nephritis (Alport Syndrome)
03/2010
1Kidney Diseases (Kidney Disease)
03/2010
1Chest Pain (Chest Pains)
01/2010
1Genetic Predisposition to Disease (Genetic Predisposition)
05/2009
1Herpes Simplex
10/2008
1Eating Disorders (Eating Disorder)
01/2008
1Bradycardia
06/2006

Drug/Important Bio-Agent (IBA)

47orexins (orexin)IBA
06/2015 - 12/2002
14NeuropeptidesIBA
06/2015 - 05/2004
5PeptidesIBA
05/2014 - 03/2004
4LeptinIBA
09/2013 - 03/2004
3orexin receptorsIBA
01/2015 - 02/2013
2Glucose (Dextrose)FDA LinkGeneric
02/2015 - 03/2004
2Glutamic Acid (Glutamate)FDA Link
11/2013 - 01/2011
2Blood Glucose (Blood Sugar)IBA
06/2013 - 09/2003
2FibrinIBA
07/2011 - 06/2011
2Evans Blue (Blue, Evans)FDA Link
01/2011 - 01/2010
2Nitroglycerin (Dynamite)FDA LinkGeneric
01/2011 - 10/2002
2Acetylcholine (Acetylcholine Chloride)FDA Link
06/2010 - 07/2002
2Insulin (Novolin)FDA Link
01/2009 - 09/2003
24-nitrophenethyl bromide (NPB)IBA
01/2008 - 05/2003
2Lipoproteins (Lipoprotein)IBA
09/2003 - 07/2002
2Lipoprotein Lipase (Diacylglycerol Lipase)IBA
07/2002 - 01/2002
1Methamphetamine (Desoxyn)FDA LinkGeneric
01/2015
1tyramine-deoxysorbitolIBA
01/2015
1Doxycycline (Vibramycin)FDA LinkGeneric
05/2014
1Diphtheria ToxinIBA
05/2014
1Dinoprostone (PGE2)FDA Link
11/2013
1Excitatory Amino Acid AntagonistsIBA
11/2013
1tebufenozide (Mimic)IBA
11/2013
1Antipsychotic Agents (Antipsychotics)IBA
05/2013
1Messenger RNA (mRNA)IBA
03/2013
1salicylhydroxamic acid (SHAM)IBA
03/2013
1Interleukin-6 (Interleukin 6)IBA
03/2013
1Proteins (Proteins, Gene)IBA
08/2012
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
01/2012
1Tyrosine (L-Tyrosine)FDA Link
10/2011
1Protein Tyrosine PhosphatasesIBA
10/2011
1Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA
01/2011
1Dopamine (Intropin)FDA LinkGeneric
01/2011
1Phenobarbital (Luminal)FDA Link
11/2010
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
06/2010
1CatecholaminesIBA
06/2010
1Fluorescein (Funduscein)FDA LinkGeneric
05/2010
1aspartate-glutamate carrierIBA
05/2010
1Bone Morphogenetic Protein 7IBA
03/2010
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
03/2010
1CollagenIBA
03/2010
1UbiquitinIBA
05/2009
1AutoantibodiesIBA
01/2009
1GABA-B Receptor AgonistsIBA
07/2006
1GABA-B Receptors (Receptor, GABA-B)IBA
07/2006
1CalciumIBA
07/2006
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
06/2006
1Atenolol (Tenormin)FDA LinkGeneric
06/2006

Therapy/Procedure

4Stents
01/2011 - 07/2003
1Therapeutics
11/2015
1Injections
11/2013
1Angioplasty (Angioplasty, Transluminal)
02/2006