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Hitoshi Sakuraba Selected Research

Cathepsin A

4/2006Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
5/2004Expression of lysosomal protective protein/cathepsin A in a stably transformed human neuroblastoma cell line during bi-directional differentiation into neuronal and Schwannian cells.

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Hitoshi Sakuraba Research Topics

Disease

30Fabry Disease (Fabry's Disease)
07/2015 - 10/2002
7Sandhoff Disease (Sandhoff's Disease)
01/2013 - 08/2006
6GM2 Gangliosidoses (GM2 Gangliosidosis)
06/2011 - 01/2002
6Tay-Sachs Disease
06/2011 - 01/2003
5Mucopolysaccharidoses
02/2014 - 04/2008
5Glycogen Storage Disease Type II (Pompe's Disease)
06/2011 - 01/2004
5Mucolipidoses (Sialidosis)
03/2007 - 01/2002
3Mucopolysaccharidosis IV (Morquio Syndrome)
09/2009 - 01/2003
3Lysosomal Storage Diseases (Lysosomal Storage Disease)
09/2009 - 04/2006
2Globoid Cell Leukodystrophy (Krabbe Disease)
09/2015 - 01/2014
2Costello Syndrome
08/2008 - 08/2006
2Nervous System Diseases (Neurological Disorders)
08/2006 - 01/2004
2Neuroblastoma
07/2004 - 05/2004
1Wilms Tumor (Wilm's Tumor)
05/2015
1Demyelinating Diseases (Demyelinating Disease)
01/2014
1Bernard-Soulier Syndrome (Giant Platelet Syndrome)
04/2013
1Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
01/2013
1Chronic Kidney Failure (Chronic Renal Failure)
09/2012
1Wolman Disease (Wolman's Disease)
02/2012
1Cholesterol Ester Storage Disease
02/2012
1Metabolic Diseases (Metabolic Disease)
04/2011
1Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
08/2010
1GM1 Gangliosidosis (Gangliosidosis GM1)
09/2009
1Aspartylglucosaminuria
12/2008
1Mucopolysaccharidosis I (Hurler Syndrome)
09/2008
1Cardiomyopathies (Cardiomyopathy)
10/2006
1Distal Myopathies (Distal Muscular Dystrophy)
04/2005

Drug/Important Bio-Agent (IBA)

12alpha-Galactosidase (Beano)IBA
09/2010 - 10/2002
10GalactosidasesIBA
05/2015 - 05/2011
6beta-N-AcetylhexosaminidasesIBA
08/2010 - 01/2002
5globotriaosyl lysosphingolipidIBA
07/2015 - 07/2010
5globotriaosylceramide (globotriosylceramide)IBA
05/2015 - 11/2009
5G(M2) Ganglioside (Ganglioside GM2)IBA
08/2010 - 08/2006
5Proteins (Proteins, Gene)IBA
08/2010 - 04/2006
4Iduronidase (alpha-L-Iduronidase)IBA
02/2014 - 09/2008
4Glycoproteins (Glycoprotein)IBA
04/2013 - 12/2002
4Messenger RNA (mRNA)IBA
01/2013 - 02/2006
4Imino SugarsIBA
06/2011 - 05/2008
4Hexosaminidase A (Hex A)IBA
06/2011 - 01/2003
4alpha-Glucosidases (Acid Maltase)IBA
06/2009 - 01/2004
4Neuraminidase deficiency with beta-galactosidase deficiencyIBA
04/2006 - 01/2003
3AntibodiesIBA
05/2015 - 03/2007
3GlycosphingolipidsIBA
01/2015 - 01/2012
3Mannose (D-Mannose)IBA
04/2011 - 01/2006
3beta-Galactosidase (Lactaid)IBA
09/2009 - 01/2003
3EnzymesIBA
03/2007 - 01/2002
35'-deoxy-5'-phosphonomethyladenosine phosphateIBA
04/2006 - 05/2004
2GalactosylceramidaseIBA
09/2015 - 01/2014
2agalsidase betaFDA Link
01/2015 - 01/2006
2Biological Markers (Surrogate Marker)IBA
01/2015 - 07/2010
2Hexosaminidases (Hexosaminidase)IBA
01/2013 - 06/2011
2N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA
04/2012 - 04/2008
2PolysaccharidesIBA
01/2012 - 09/2009
2agalsidase alfaIBA
01/2012 - 01/2006
2alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)IBA
11/2009 - 01/2004
2TropoelastinIBA
08/2008 - 08/2006
2GlycoconjugatesIBA
03/2007 - 06/2004
2LectinsIBA
03/2007 - 06/2004
2Neuraminidase (Sialidase)IBA
04/2006 - 01/2002
2Complementary DNA (cDNA)IBA
04/2006 - 05/2004
2Cathepsin AIBA
04/2006 - 05/2004
1podocalyxinIBA
05/2015
1VimentinIBA
05/2015
1Protein Isoforms (Isoforms)IBA
01/2015
11-deoxygalactonojirimycinIBA
07/2014
1Psychosine (Galactosylsphingosine)IBA
01/2014
1Heparitin Sulfate (Heparan Sulfate)IBA
09/2013
1von Willebrand factor receptor (VWF receptor)IBA
04/2013
1von Willebrand FactorIBA
04/2013
1ThrombinFDA Link
04/2013
1RistocetinIBA
04/2013
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
11/2012
1tartaric acid (tartrate)FDA Link
11/2012
1Sterol Esterase (Hormone-Sensitive Lipase)IBA
02/2012
1Hexosaminidase BIBA
06/2011
1lysoganglioside G(M2)IBA
01/2011
1GlycolipidsIBA
09/2010
1palmitoyl-protein thioesteraseIBA
08/2010
1Aspartylglucosylaminase (Aspartylglucosaminidase)IBA
12/2008
1CytokinesIBA
08/2008
1CollagenIBA
08/2008
1ChemokinesIBA
08/2008
1Interleukin-8 (Interleukin 8)IBA
08/2008
1Interleukin-1beta (Interleukin 1 beta)IBA
08/2008
1Proteoglycans (Proteoglycan)IBA
08/2008
1GangliosidesIBA
08/2007
1Monoclonal AntibodiesIBA
03/2007
1IsoenzymesIBA
03/2007
1Mutant Proteins (Protein, Mutant)IBA
01/2007
1Nonsense Codon (Nonsense Mutation)IBA
01/2007
1PhospholipidsIBA
10/2006
1Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseIBA
04/2006
1sialooligosaccharidesIBA
04/2006
1Fluorescein-5-isothiocyanate (FITC)IBA
04/2006
1AvidinIBA
04/2006
1mannose-6-phosphateIBA
01/2006
1Tyrosine (L-Tyrosine)FDA Link
07/2004

Therapy/Procedure

14Enzyme Replacement Therapy
01/2015 - 10/2002
1Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/2013
1Renal Dialysis (Hemodialysis)
09/2012