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Stephen Safe Selected Research

Cyclin D1

1/2015Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.
7/2014MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.
2/2014Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors.
12/2013Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.
4/2012Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.
1/2012Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.
1/2012Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors.
1/2011Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
1/2011Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
11/2010Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer.
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Stephen Safe Research Topics

Disease

97Neoplasms (Cancer)
10/2015 - 03/2002
63Breast Neoplasms (Breast Cancer)
10/2015 - 01/2002
35Pancreatic Neoplasms (Pancreatic Cancer)
09/2015 - 09/2002
28Colonic Neoplasms (Colon Cancer)
10/2015 - 09/2004
10Neoplasm Metastasis (Metastasis)
01/2014 - 11/2005
10Prostatic Neoplasms (Prostate Cancer)
11/2012 - 06/2002
7Urinary Bladder Neoplasms (Bladder Cancer)
04/2012 - 01/2006
5Leukemia
05/2015 - 12/2005
5Lung Neoplasms (Lung Cancer)
11/2012 - 01/2009
4Parkinson Disease (Parkinson's Disease)
10/2015 - 11/2009
4Liver Neoplasms (Liver Cancer)
05/2015 - 01/2003
4Inflammation
01/2014 - 01/2011
3Hepatocellular Carcinoma (Hepatoma)
09/2015 - 11/2004
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2013 - 03/2010
3Endometrial Neoplasms (Endometrial Cancer)
07/2008 - 06/2002
2Rhabdomyosarcoma
09/2015 - 02/2013
2Skin Neoplasms (Skin Cancer)
07/2015 - 01/2013
2Renal Cell Carcinoma (Grawitz Tumor)
01/2015 - 11/2007
2Insulin Resistance
01/2014 - 06/2012
2Esophageal Neoplasms (Esophageal Cancer)
06/2012 - 07/2009
2Pituitary Neoplasms (Pituitary Adenoma)
09/2011 - 01/2011
2Necrosis
01/2011 - 10/2010
2Adenocarcinoma
03/2009 - 11/2007
2Anoxia (Hypoxia)
08/2007 - 10/2002

Drug/Important Bio-Agent (IBA)

37Proteins (Proteins, Gene)IBA
09/2015 - 06/2003
34Estrogens (Estrogen)FDA Link
09/2015 - 06/2002
33Sp Transcription FactorsIBA
09/2015 - 03/2007
23Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2015 - 02/2004
23PPAR gammaIBA
06/2010 - 03/2003
22Messenger RNA (mRNA)IBA
10/2015 - 08/2002
21Estrogen Receptor alphaIBA
06/2010 - 01/2002
17Cyclin D1IBA
01/2015 - 03/2003
15Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
05/2015 - 06/2002
15HormonesIBA
09/2011 - 06/2002
13Tetrachlorodibenzodioxin (TCDD)IBA
09/2015 - 06/2002
12tolfenamic acidIBA
02/2014 - 06/2006
11Transcription Factors (Transcription Factor)IBA
06/2012 - 05/2003
9LigandsIBA
10/2015 - 03/2003
91,1- bis(3'- indolyl)- 1- (4- t- butylphenyl)methaneIBA
09/2011 - 09/2004
8Cytochrome P-450 CYP1A1 (CYP1A1)IBA
10/2015 - 01/2004
8MicroRNAs (MicroRNA)IBA
07/2014 - 01/2006
7Epidermal Growth Factor Receptor (EGF Receptor)IBA
10/2015 - 05/2010
7diindolylmethaneIBA
06/2015 - 01/2009
7betulinic acidIBA
12/2014 - 03/2007
7LuciferasesIBA
10/2014 - 02/2004
7methyl 2- cyano- 3,11- dioxo- 18beta- olean- 1,12- dien- 30- oateIBA
09/2012 - 05/2007
7Caveolin 1IBA
05/2010 - 09/2004
6Reactive Oxygen Species (Oxygen Radicals)IBA
09/2015 - 08/2010
6Proteasome Endopeptidase Complex (Proteasome)IBA
01/2011 - 10/2002
5Proto-Oncogene Proteins c-metIBA
02/2014 - 07/2009
4CurcuminIBA
01/2012 - 07/2008
4TamoxifenFDA LinkGeneric
01/2012 - 06/2002
46-methyl-1,3,8-trichlorodibenzofuranIBA
01/2012 - 04/2004
4Phosphotransferases (Kinase)IBA
11/2010 - 12/2005
4Estrogen Receptor Modulators (Antiestrogen)IBA
11/2008 - 05/2003
3Member 2 Group A Nuclear Receptor Subfamily 4IBA
10/2015 - 12/2008
3Metformin (Glucophage)FDA LinkGeneric
09/2015 - 12/2013
3Omeprazole (Esomeprazole)FDA LinkGeneric
05/2015 - 11/2012
3Sulindac (Copal)FDA LinkGeneric
01/2015 - 11/2012
3Member 1 Group A Nuclear Receptor Subfamily 4IBA
01/2015 - 09/2010
31,1- bis(3'- indolyl)- 1- (4- hydroxyphenyl)methaneIBA
10/2014 - 09/2010
31,1- bis(3'- indolyl)- 1- (4- biphenyl)methaneIBA
07/2014 - 01/2007
3Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
02/2014 - 06/2006
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
08/2013 - 07/2008
3Glutathione (Reduced Glutathione)IBA
02/2011 - 10/2005
3docetaxel (Taxotere)FDA Link
11/2010 - 01/2009
3Small Interfering RNA (siRNA)IBA
09/2010 - 08/2002
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2010 - 07/2005
3Nerve Growth Factor (NGF)IBA
03/2010 - 10/2008
35,5'-dibromo-1,1-bis(3'-indolyl)methaneIBA
03/2010 - 05/2006
3Glycyrrhetinic Acid (Po 12)IBA
08/2009 - 05/2007
3Cyclin-Dependent Kinase Inhibitor p21IBA
07/2009 - 09/2002
3Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
02/2008 - 06/2006
3RNA (Ribonucleic Acid)IBA
07/2005 - 08/2002
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2015 - 02/2015
2ThioredoxinsIBA
10/2015 - 04/2014
2Antineoplastic Agents (Antineoplastics)IBA
09/2015 - 03/2002
2cytochrome P-450 CYP1B1 (CYP1B1)IBA
09/2015 - 11/2012
2Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
06/2015 - 06/2011
2tranilast (N 5')IBA
05/2015 - 01/2014
2ChromatinIBA
05/2015 - 11/2004
2Sirolimus (Rapamycin)FDA Link
10/2014 - 10/2014
2Orphan Nuclear ReceptorsIBA
02/2014 - 03/2010
2leflunomide (Arava)FDA LinkGeneric
01/2014 - 11/2012
2resveratrolIBA
01/2013 - 05/2008
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2012 - 01/2011
23,3'-diindolylmethaneIBA
09/2011 - 04/2006
2MethylcholanthreneIBA
09/2010 - 02/2006
2methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oateIBA
08/2010 - 07/2005
2Mediator Complex Subunit 1IBA
06/2010 - 12/2004
2indoleIBA
05/2010 - 10/2008
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2008 - 07/2005
2CCAAT-Enhancer-Binding ProteinsIBA
10/2008 - 06/2008
2EstersIBA
04/2008 - 07/2005
23,4,5,3',4'-pentachlorobiphenylIBA
03/2008 - 02/2006
2cobaltous chloride (cobalt(II)chloride)IBA
08/2007 - 10/2002
2Androgen Receptors (Androgen Receptor)IBA
02/2007 - 06/2002

Therapy/Procedure

22Heterologous Transplantation (Xenotransplantation)
01/2015 - 07/2005
14Drug Therapy (Chemotherapy)
10/2015 - 11/2005
3Chemoprevention
07/2015 - 06/2012