Stephen Safe Selected Research

Estrogens (Estrogen)

05/2008	1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.
10/2007	Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.
01/2007	Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.
09/2006	Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.
04/2005	Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.
07/2004	Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways.
02/2004	Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.
06/2003	Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.
05/2003	Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.
10/2002	Environmental estrogens: roles in male reproductive tract problems and in breast cancer.
08/2002	Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.
08/2002	Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.
06/2002	Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.

Articles by Research Topic

Disease

27	Breast Neoplasms (Breast Cancer) 05/2008 - 01/2002
10	Pancreatic Neoplasms (Pancreatic Cancer) 04/2008 - 09/2004
8	Colonic Neoplasms (Colon Cancer) 07/2008 - 09/2004
5	Neoplasms (Cancer) 10/2008 - 06/2002
4	Prostatic Neoplasms (Prostate Cancer) 02/2008 - 01/2004
2	Urinary Bladder Neoplasms (Bladder Cancer) 07/2008 - 01/2006
2	Anoxia (Hypoxia) 08/2007 - 10/2002
1	Hepatocellular Carcinoma (Hepatoma) 11/2004
1	Liver Neoplasms (Liver Cancer) 01/2003
1	Carcinoma (Carcinomatosis) 03/2002

Drug/Important Bio-Agent (IBA)

13	Estrogens (Estrogen)FDA Link 05/2008 - 06/2002
12	PPAR gammaIBA 02/2008 - 03/2003
10	Estrogen Receptor alphaIBA 02/2008 - 01/2002
9	Proteins (Proteins, Gene)IBA 02/2008 - 02/2004
6	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 08/2007 - 06/2002
3	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 02/2008 - 06/2006
3	Sp Transcription FactorsIBA 11/2007 - 03/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2005 - 02/2004
2	Estradiol (Estrace)FDA LinkGeneric 02/2008 - 01/2003
2	betulinic acidIBA 11/2007 - 03/2007
2	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2007 - 05/2003
2	Transcription Factors (Transcription Factor)IBA 01/2006 - 11/2005
2	HormonesIBA 01/2004 - 06/2002
2	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2003 - 10/2002
1	indole-3-carbinolIBA 10/2008
1	GKLF proteinIBA 07/2008
1	CurcuminIBA 07/2008
1	JNK Mitogen-Activated Protein KinasesIBA 06/2008
1	ursolic acidIBA 04/2008
1	cobaltous chloride (cobalt(II)chloride)IBA 08/2007
1	Glycyrrhetinic Acid (Po 12)IBA 05/2007
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 04/2007
1	Androgen Receptors (Androgen Receptor)IBA 02/2007
1	1,1- bis(3'- indolyl)- 1- (4- biphenyl)methaneIBA 01/2007
1	tolfenamic acidIBA 06/2006
1	5,5'-dibromo-1,1-bis(3'-indolyl)methaneIBA 05/2006
1	1,1-bis(3'-indolyl)methaneIBA 05/2006
1	3,3'-diindolylmethaneIBA 04/2006
1	Glutathione (Reduced Glutathione)IBA 10/2005
1	1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA 10/2005
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 08/2005
1	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acidIBA 07/2005
1	CytochromesIBA 11/2004
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 11/2004
1	Differentiation AntigensIBA 09/2004
1	lactate dehydrogenase 5IBA 07/2004
1	Protein Kinase CIBA 07/2004
1	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 07/2004
1	Cyclin D1IBA 03/2003
1	Messenger RNA (mRNA)IBA 08/2002
1	RNA (Ribonucleic Acid)IBA 08/2002
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 08/2002
1	Serum Response FactorIBA 06/2002
1	Doxycycline (Vibramycin)FDA LinkGeneric 03/2002
1	P-GlycoproteinIBA 03/2002
1	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 10/2008