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Alexandra Rucavado Selected Research

Venoms

5/2015Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection.
4/2015Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.
1/2015The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay.
9/2013Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico.
9/2013Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P-I metalloproteinase from Bothrops asper snake venom: insights from docking and molecular modeling.
3/2013Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model.
7/2012Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design.
1/2011Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves.
12/2009Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment.
12/2009Experimental pathology of local tissue damage induced by Bothrops asper snake venom.
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Alexandra Rucavado Research Topics

Disease

20Hemorrhage
05/2015 - 04/2002
8Snake Bites (Snake Bite)
09/2013 - 10/2003
6Edema
09/2013 - 04/2002
4Thrombocytopenia (Thrombopenia)
03/2013 - 02/2004
3Wounds and Injuries (Trauma)
01/2012 - 11/2009
2Hypovolemia
01/2015 - 12/2009
2Thrombosis (Thrombus)
03/2013 - 10/2003
2Rupture
01/2006 - 02/2005
1Melanoma (Melanoma, Malignant)
12/2014
1Necrosis
01/2011
1Fibrosis (Cirrhosis)
01/2011
1Ischemia
12/2009
1Shock
12/2009
1Bacterial Infections (Bacterial Infection)
12/2009
1Blister (Bulla)
10/2008
1Hemolysis
03/2007

Drug/Important Bio-Agent (IBA)

18VenomsIBA
05/2015 - 10/2003
12Snake Venoms (Snake Venom)IBA
04/2015 - 11/2003
10Metalloproteases (Metalloproteinases)IBA
04/2015 - 06/2005
4batimastat (BB 94)IBA
07/2012 - 04/2002
3Laminin (Merosin)IBA
04/2015 - 10/2008
3Extracellular Matrix ProteinsIBA
12/2014 - 11/2009
3estropipate (Ogen)FDA LinkGeneric
03/2013 - 07/2005
3Antivenins (Antivenoms)IBA
01/2012 - 01/2007
2EnzymesIBA
04/2015 - 12/2009
2Collagen Type IV (Type IV Collagen)IBA
04/2015 - 10/2008
2Fibronectins (Fibronectin)IBA
12/2014 - 11/2009
2AntibodiesIBA
12/2009 - 03/2007
2Phospholipases (Phospholipase)IBA
11/2009 - 10/2008
2jararhaginIBA
07/2005 - 11/2003
1Hemoglobins (Hemoglobin)IBA
05/2015
1nidogen (entactin)IBA
04/2015
1Collagen Type VIIBA
04/2015
1VitronectinIBA
12/2014
1Collagen Type I (Type I Collagen)IBA
12/2014
1DisintegrinsIBA
12/2014
1Toxic ActionsIBA
09/2013
1Creatine Kinase (Creatine Phosphokinase)IBA
09/2013
1glycolic acid (glycolate)IBA
09/2013
1Serine Proteases (Serine Protease)IBA
03/2013
1fibrin fragment D (D-dimer)IBA
03/2013
1ZincIBA
07/2012
1Immunoglobulin G (IgG)IBA
01/2012
1Biological Markers (Surrogate Marker)IBA
04/2011
1C-Type Lectins (C-Type Lectin)IBA
12/2009
1Fibrillar CollagensIBA
11/2009
1Non-Fibrillar CollagensIBA
11/2009
1Apolipoproteins AIBA
11/2009
1ApolipoproteinsIBA
11/2009
1Phospholipases A2 (Phospholipase A2)IBA
11/2009
1Doxycycline (Vibramycin)FDA LinkGeneric
12/2008
1Clodronic Acid (Clodronate)IBA
12/2008
1Proteins (Proteins, Gene)IBA
10/2008
1Sodium Chloride (Saline Solution)FDA LinkGeneric
01/2006
1aspercetinIBA
07/2005
1DNA (Deoxyribonucleic Acid)IBA
02/2005
1Blood Proteins (Serum Proteins)IBA
11/2003
1Prothrombin (Factor II)IBA
10/2003
1Matrix MetalloproteinasesIBA
04/2002
1growth inhibitory factorIBA
04/2002

Therapy/Procedure

1Intravenous Injections
07/2005