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Serge Przedborski Selected Research

Parkinson Disease (Parkinson's Disease)

01/2007Protocol for the MPTP mouse model of Parkinson's disease.
08/2006Proteasome inhibition and Parkinson's disease modeling.
07/2005Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
05/2005Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease.
08/2004MPTP as a mitochondrial neurotoxic model of Parkinson's disease.
07/2004L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease.
02/2004Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
01/2004JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
11/2003Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.
09/2003D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.
07/2003The rotenone model of Parkinson's disease.
06/2003Nitric oxide and reactive oxygen species in Parkinson's disease.
06/2003The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease.
05/2003Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.
05/2003NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
04/2003Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration.
01/2003Free radical and nitric oxide toxicity in Parkinson's disease.
03/2002Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

Articles by Research Topic

Disease

18Parkinson Disease (Parkinson's Disease)
01/2007 - 03/2002
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
08/2006 - 05/2002
1Primary Progressive Aphasia (Progressive Nonfluent Aphasia)
12/2005
1Parkinsonian Disorders (Parkinsonism)
11/2005
1Huntington Disease (Huntington's Disease)
12/2003

Drug/Important Bio-Agent (IBA)

71- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2007 - 03/2002
2NADPH Oxidase (NAD(P)H oxidase)IBA
08/2006 - 05/2003
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2004 - 04/2003
2Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2003 - 01/2003
1Proteasome Endopeptidase Complex (Proteasome)IBA
08/2006
1Codon (Codons)IBA
12/2005
1Dopamine (Intropin)FDA LinkGeneric
11/2005
1Peroxidase (Myeloperoxidase)IBA
07/2005
1OxygenIBA
05/2005
1NitrogenIBA
05/2005
1OxidoreductasesIBA
07/2004
1CaspasesIBA
12/2003
1Cyclin-Dependent Kinase 5IBA
11/2003
13-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA
09/2003
1RotenoneIBA
07/2003
1Reactive Oxygen Species (Oxygen Radicals)IBA
06/2003
1Cytochromes c (Cytochrome c)IBA
05/2002
1Minocycline (Cyclops)FDA LinkGeneric
05/2002