Janus Kinase 2

A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

Also Known As:

JAK-2 Protein Tyrosine Kinase; JAK2 Protein Tyrosine Kinase; JAK 2 Protein Tyrosine Kinase

Enzymes and Coenzymes: 1
- Enzymes: 25006
  - Transferases: 3229
    - Phosphotransferases: 16675
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 5788
        Protein-Tyrosine Kinases: 6303
        Janus Kinases: 39
        Janus Kinase 2: 118
Amino Acids, Peptides, and Proteins
- Proteins: 58343
  - Intracellular Signaling Peptides and Proteins: 17
    - Janus Kinases: 39
      - Janus Kinase 2: 118
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 1282
      - Proto-Oncogene Proteins: 4
        Janus Kinase 2: 118

Daniel Prater Selected Research

Daniel Prater Research Topics

Disease

Drug/Important Bio-Agent (IBA)