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Yves Pommier Selected Research

Topotecan (Hycamtin)

12/2014ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
9/2014Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
10/2012A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.
1/2012Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.
12/2011Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.
9/2011Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas.
11/2010Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
11/20094-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
12/2007Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
2/2004Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
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Yves Pommier Research Topics

Disease

90Neoplasms (Cancer)
11/2015 - 01/2002
19Carcinoma (Carcinomatosis)
09/2015 - 10/2002
15Poisoning
05/2015 - 08/2002
13Breast Neoplasms (Breast Cancer)
09/2012 - 01/2003
12Leukemia
08/2015 - 08/2002
11Acquired Immunodeficiency Syndrome (AIDS)
01/2016 - 12/2002
8Genomic Instability
04/2015 - 09/2007
8Ataxia Telangiectasia (Louis Bar Syndrome)
12/2009 - 05/2003
7Infection
01/2016 - 01/2009
7Hypersensitivity (Allergy)
02/2015 - 10/2006
5Sarcoma (Soft Tissue Sarcoma)
09/2015 - 07/2002
5Colonic Neoplasms (Colon Cancer)
08/2011 - 03/2002
3Lung Neoplasms (Lung Cancer)
08/2015 - 08/2002
3Colorectal Neoplasms (Colorectal Cancer)
06/2015 - 05/2004
3Lymphoma (Lymphomas)
06/2014 - 12/2003
3Glioblastoma (Glioblastoma Multiforme)
06/2014 - 02/2008
3HIV Infections (HIV Infection)
11/2011 - 03/2005
3Anoxia (Hypoxia)
01/2008 - 02/2004
2Fanconi Anemia (Fanconi's Anemia)
04/2015 - 11/2012
2Melanoma (Melanoma, Malignant)
12/2012 - 08/2011
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
09/2012 - 04/2011
2Neoplasm Metastasis (Metastasis)
12/2010 - 05/2004
2Cockayne Syndrome (Syndrome, Cockayne)
10/2008 - 09/2002
2Xeroderma Pigmentosum (Kaposi's Disease)
10/2008 - 09/2002
2Visceral Leishmaniasis (Kala Azar)
09/2008 - 12/2007
1Pheochromocytoma
11/2015
1Wounds and Injuries (Trauma)
09/2015
1Burkitt Lymphoma (Burkitt's Lymphoma)
06/2015
1Leukemia P388
10/2014
1Heart Failure
09/2014
1Immune System Diseases (Immune Disorders)
06/2014
1Werner Syndrome (Werner's Syndrome)
03/2014

Drug/Important Bio-Agent (IBA)

44DNA (Deoxyribonucleic Acid)IBA
04/2015 - 04/2003
43Type I DNA Topoisomerases (Topoisomerase I)IBA
11/2015 - 01/2002
32CamptothecinIBA
09/2015 - 02/2002
12Topotecan (Hycamtin)FDA LinkGeneric
12/2014 - 08/2002
8Doxorubicin (Adriamycin)FDA LinkGeneric
10/2014 - 01/2003
8Phosphotransferases (Kinase)IBA
12/2009 - 10/2002
7irinotecan (Camptosar)FDA LinkGeneric
12/2014 - 08/2002
7Human immunodeficiency virus 1 p31 integrase proteinIBA
06/2014 - 09/2008
7Cisplatin (Platino)FDA LinkGeneric
09/2012 - 09/2002
6IntegrasesIBA
01/2016 - 03/2006
6Topoisomerase I InhibitorsIBA
09/2015 - 01/2003
5trabectedin (ecteinascidin 743)IBA
03/2014 - 12/2002
51,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2014 - 12/2008
5MK 0518FDA Link
12/2012 - 09/2008
4Transcription Factors (Transcription Factor)IBA
09/2015 - 07/2004
4tyrosyl-DNA phosphodiesteraseIBA
05/2014 - 12/2006
4Small Interfering RNA (siRNA)IBA
03/2014 - 09/2007
4Messenger RNA (mRNA)IBA
08/2011 - 12/2002
4Etoposide (VP 16)FDA LinkGeneric
05/2010 - 11/2003
3EWS-FLI1 fusion proteinIBA
09/2015 - 02/2011
3Topoisomerase InhibitorsIBA
04/2015 - 01/2010
3Carbon MonoxideIBA
01/2012 - 01/2011
3checkpoint kinase 2IBA
12/2011 - 01/2009
3Proteins (Proteins, Gene)IBA
01/2011 - 12/2003
3Histones (Histone)IBA
01/2010 - 06/2005
3DNA-Activated Protein KinaseIBA
12/2009 - 05/2003
3aminoflavoneIBA
04/2008 - 06/2005
3P-GlycoproteinIBA
12/2007 - 12/2002
3AphidicolinIBA
09/2007 - 05/2003
37-hydroxystaurosporine (UCN 01)IBA
06/2004 - 10/2002
2Anti-Retroviral Agents (Antiretroviral Agents)IBA
01/2016 - 02/2014
2Hypoxia-Inducible Factor 1IBA
11/2015 - 02/2004
2Mitochondrial DNA (mtDNA)IBA
09/2015 - 09/2014
2Serine (L-Serine)FDA Link
06/2015 - 10/2011
2PoisonsIBA
05/2015 - 12/2012
2A-Form DNA (A-DNA)IBA
02/2015 - 01/2005
2Biological Markers (Surrogate Marker)IBA
01/2013 - 06/2005
2JTK 303IBA
12/2012 - 09/2008
2DNA TopoisomerasesIBA
10/2012 - 05/2010
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2011 - 09/2010
2Histone Deacetylase InhibitorsIBA
09/2011 - 11/2003
2Fluorouracil (Carac)FDA LinkGeneric
12/2010 - 11/2003
2ChromatinIBA
06/2010 - 11/2009
2Mitoxantrone (Novantrone)FDA LinkGeneric
05/2010 - 12/2007
2gemcitabineFDA Link
03/2010 - 08/2002
2Protein Kinases (Protein Kinase)IBA
12/2009 - 10/2005
2Cytochrome P-450 CYP1A1 (CYP1A1)IBA
04/2008 - 07/2006
2HormonesIBA
04/2008 - 01/2006
2StaurosporineIBA
09/2007 - 03/2003
2trioctyl phosphine oxide (TOPO)IBA
03/2005 - 12/2003
26- (3- (2- hydroxyethyl)amino- 1- propyl)- 5,6- dihydro- 2,3- dimethoxy- 8,9- methylenedioxy- 5,11- dioxo- 11H- indeno(1,2- )isoquinolineIBA
02/2005 - 11/2003
2Cytarabine (Cytosar-U)FDA LinkGeneric
06/2004 - 04/2003
2Complementary DNA (cDNA)IBA
03/2003 - 03/2002
1temozolomide (Temodar)FDA LinkGeneric
09/2015
1Ethidium (Ethidium Bromide)IBA
09/2015
13- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazoleIBA
08/2015
1ChlorineIBA
05/2015
1FluorineIBA
05/2015
1Immunoglobulins (Immunoglobulin)IBA
02/2015
1bis(p-chlorophenyl)acetic acid (DDA)IBA
02/2015
1pemetrexed (MTA)FDA Link
02/2015
1lamellarin DIBA
08/2014
1NucleosidesIBA
01/2014

Therapy/Procedure

11Drug Therapy (Chemotherapy)
11/2015 - 07/2002
6Therapeutics
01/2016 - 03/2006
5Heterologous Transplantation (Xenotransplantation)
03/2014 - 01/2003
1Hepatectomy
09/2015
1Transplants (Transplant)
10/2014