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Pal Pacher Selected Research

Peroxynitrous Acid (Peroxynitrite)

3/2013Role of peroxynitrite in the cardiovascular dysfunction of septic shock.
1/2013Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo.
6/2011Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis.
2/2011Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo.
5/2009Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.
1/2009Role of peroxynitrite in the redox regulation of cell signal transduction pathways.
7/2008Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease.
12/2007Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes.
8/2007A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.
9/2006Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo.
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Pal Pacher Research Topics

Disease

16Inflammation
07/2015 - 01/2006
7Diabetes Complications
10/2011 - 08/2003
7Diabetic Neuropathies (Diabetic Neuropathy)
05/2009 - 03/2004
6Atherosclerosis
01/2015 - 06/2002
6Hyperglycemia
06/2012 - 02/2002
6Necrosis
02/2011 - 09/2006
5Cardiovascular Diseases (Cardiovascular Disease)
01/2015 - 07/2005
5Ischemia
01/2013 - 01/2002
4Fibrosis (Cirrhosis)
10/2015 - 01/2008
4Peripheral Nervous System Diseases (PNS Diseases)
10/2011 - 12/2007
4Reperfusion Injury
07/2010 - 06/2002
3Pneumonia (Pneumonitis)
10/2015 - 08/2011
3Sepsis (Septicemia)
03/2013 - 01/2010
3Septic Shock (Toxic Shock Syndrome)
03/2013 - 01/2010
3Hypertension (High Blood Pressure)
12/2012 - 06/2002
3Hypertrophy
10/2011 - 08/2007
3Myocardial Infarction
02/2011 - 04/2002
3Neoplasms (Cancer)
01/2011 - 02/2008
3Neuralgia (Stump Neuralgia)
05/2009 - 07/2007
3Heart Failure
01/2009 - 06/2005
3Pain (Aches)
02/2008 - 06/2006
2Cardiomyopathies (Cardiomyopathy)
11/2014 - 07/2008
2Neointima
05/2013 - 03/2012
2Multiple Organ Failure (MODS)
03/2013 - 05/2009
2Obesity
12/2012 - 03/2011
2Cataract (Cataracts)
06/2012 - 06/2008
2Edema
08/2011 - 09/2009
2Acute Lung Injury
08/2011 - 09/2009
2Lung Injury
06/2011 - 12/2002
2Hyperalgesia
03/2011 - 06/2006
2Liver Diseases (Liver Disease)
05/2010 - 05/2009
2Metabolic Diseases (Metabolic Disease)
11/2009 - 07/2009
2Stroke (Strokes)
07/2008 - 12/2006
2Shock
07/2008 - 06/2002
2Myocardial Ischemia (Ischemic Heart Diseases)
07/2008 - 09/2006
2Diabetic Nephropathies (Diabetic Nephropathy)
04/2006 - 08/2003
1Alcoholic Hepatitis
10/2015
1Pulmonary Fibrosis (Hamman Rich Syndrome)
10/2015
1Mitochondrial Diseases (Mitochondrial Disease)
02/2015
1Breast Neoplasms (Breast Cancer)
01/2013
1Gram-Negative Bacterial Infections
12/2012
1Type 2 Diabetes Mellitus (MODY)
12/2012
1Insulin Resistance
12/2012
1Sleep Apnea Syndromes (Sleep Apnea)
12/2012
1Obstructive Sleep Apnea
12/2012
1Apnea
12/2012
1Infection
06/2012

Drug/Important Bio-Agent (IBA)

11Peroxynitrous Acid (Peroxynitrite)IBA
03/2013 - 06/2005
11Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
10/2011 - 06/2002
6resveratrolIBA
01/2011 - 01/2006
5Endocannabinoids (Endocannabinoid)IBA
01/2015 - 07/2007
5OxygenIBA
05/2014 - 06/2002
5CytokinesIBA
05/2010 - 01/2009
4NitrogenIBA
05/2014 - 06/2002
4Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2011 - 12/2002
4Aldehyde Reductase (Aldose Reductase)IBA
07/2010 - 01/2005
3Toll-Like Receptors (Toll-Like Receptor)IBA
07/2015 - 01/2010
3CB1 Cannabinoid Receptor (CB1 Receptor)IBA
05/2013 - 07/2007
3Cannabinoid Receptors (Cannabinoid Receptor)IBA
12/2012 - 01/2008
3Retinaldehyde (Retinal)IBA
06/2012 - 06/2008
3FlagellinIBA
06/2012 - 01/2010
3Sorbitol (Yal)FDA Link
06/2012 - 07/2010
3fidarestatIBA
07/2010 - 01/2005
3Interleukin-6 (Interleukin 6)IBA
05/2010 - 01/2010
3Caspase 3 (Caspase-3)IBA
01/2010 - 09/2006
3Reactive Oxygen Species (Oxygen Radicals)IBA
11/2009 - 07/2005
3EnzymesIBA
11/2008 - 10/2005
3CannabinoidsIBA
02/2008 - 07/2007
2Ethanol (Ethyl Alcohol)IBA
10/2015 - 04/2010
2Transcription Factors (Transcription Factor)IBA
02/2015 - 05/2010
2Carbon Tetrachloride (Tetrachloromethane)IBA
05/2014 - 05/2010
2anandamide (arachidonylethanolamide)IBA
05/2013 - 12/2012
2Free RadicalsIBA
03/2013 - 08/2007
2Glucose (Dextrose)FDA LinkGeneric
12/2012 - 06/2012
2Peroxidase (Myeloperoxidase)IBA
08/2011 - 09/2009
2NicotineFDA Link
08/2011 - 05/2009
2Superoxides (Superoxide)IBA
06/2011 - 01/2005
2NF-kappa B (NF-kB)IBA
05/2010 - 01/2010
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2010 - 05/2009
2Phosphotransferases (Kinase)IBA
01/2010 - 08/2007
2SmokeIBA
01/2009 - 06/2008
1AM6545IBA
10/2015
1Toll-Like Receptor 5IBA
07/2015
1Cocaine (Cocaine HCl)IBA
11/2014
1Poly Adenosine Diphosphate RiboseIBA
05/2014
1Apolipoproteins E (ApoE)IBA
05/2013
1IronIBA
03/2013
1ManganeseIBA
03/2013
1Mn(III) 5,10,15,20- tetrakis(N- methylpyridinium- 2- yl)porphyrinIBA
03/2013
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2013
1trastuzumab (Herceptin)FDA Link
01/2013
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
12/2012
1p38 Mitogen-Activated Protein KinasesIBA
06/2012
1cariporideIBA
06/2012
1Sodium-Hydrogen AntiporterIBA
06/2012
1CB2 Cannabinoid ReceptorIBA
03/2012

Therapy/Procedure

2Ligation
05/2014 - 06/2011
1Radiotherapy
10/2015
1Angioplasty (Angioplasty, Transluminal)
05/2013
1Ischemic Postconditioning
01/2013