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Sebastiaan Overeem Selected Research

orexins (orexin)

10/2015The effects of sodium oxybate on core body and skin temperature regulation in narcolepsy.
6/2014Challenges in diagnosing narcolepsy without cataplexy: a consensus statement.
1/2014Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study.
1/2013Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin.
1/2013Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: basal concentrations and response to sodium oxybate.
1/2013ImmunoChip study implicates antigen presentation to T cells in narcolepsy.
12/2012Association between hypocretin-1 and amyloid-β42 cerebrospinal fluid levels in Alzheimer's disease and healthy controls.
8/2012Hypocretin (orexin) loss in Alzheimer's disease.
4/2012Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men.
6/2011Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls.
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Sebastiaan Overeem Research Topics

Disease

28Narcolepsy
10/2015 - 10/2002
11Cataplexy
06/2014 - 10/2002
5Alzheimer Disease (Alzheimer's Disease)
12/2014 - 08/2012
5Parkinson Disease (Parkinson's Disease)
10/2013 - 10/2002
4Obesity
01/2014 - 09/2003
4Sleep Disorders
12/2012 - 10/2002
2Body Weight (Weight, Body)
01/2013 - 03/2003
2Nervous System Diseases (Neurological Disorders)
02/2009 - 10/2002
1Sleep Deprivation
08/2014
1Weight Loss (Weight Reduction)
01/2014
1Hallucinations (Hallucination)
09/2013
1Wounds and Injuries (Trauma)
09/2013
1Dementia (Dementias)
08/2012
1Respiratory Sounds (Crackle)
01/2011
1Fasciculation (Fasciculations)
01/2010
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2009
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
10/2009
1Huntington Disease (Huntington's Disease)
10/2008
1Abdominal Obesity
09/2003
1Sleep Initiation and Maintenance Disorders (Insomnia)
10/2002
1Disorders of Excessive Somnolence (Hypersomnia)
10/2002
1Restless Legs Syndrome (Restless Legs)
10/2002
1Prader-Willi Syndrome (Syndrome, Prader-Willi)
10/2002
1Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
10/2002
1Obstructive Sleep Apnea
10/2002

Drug/Important Bio-Agent (IBA)

31orexins (orexin)IBA
10/2015 - 10/2002
6Sodium Oxybate (gamma Hydroxybutyrate)FDA Link
10/2015 - 03/2011
2MelatoninIBA
01/2013 - 04/2012
2Growth Hormone (Somatotropin)IBA
06/2011 - 03/2003
2AntigensIBA
09/2010 - 04/2003
1Amyloid (Amyloid Fibrils)IBA
08/2014
1Biological Markers (Surrogate Marker)IBA
06/2014
1Glycerol (Glycerine)FDA LinkGeneric
01/2014
1Glucose (Dextrose)FDA LinkGeneric
01/2014
1Insulin (Novolin)FDA Link
01/2014
1HLA-DQB1 antigen (HLA DQB1)IBA
01/2014
1Transcription Factors (Transcription Factor)IBA
10/2013
1N-(4-aminophenethyl)spiroperidol (NAPS)IBA
09/2013
1Hydrocortisone (Cortisol)FDA LinkGeneric
09/2013
1propylene diquat (PDQ(+))IBA
05/2013
1Cathepsin HIBA
01/2013
1LeptinIBA
01/2013
1GhrelinIBA
01/2013
1OX40 LigandIBA
01/2013
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2013
1HormonesIBA
01/2013
1Neurotransmitter Agents (Neurotransmitter)IBA
08/2012
1Adrenocorticotropic Hormone (ACTH)FDA Link
03/2011
1ProlactinIBA
03/2011
1HLA-DRB1 antigen (HLA DRB1)IBA
09/2010
1Caffeine (No Doz)FDA LinkGeneric
01/2010
1melanin-concentrating hormone (melanin concentrating hormone)IBA
10/2008
1AutoantibodiesIBA
05/2006
1GangliosidesIBA
04/2003
1AntibodiesIBA
04/2003
1human HLA-DQB1 proteinIBA
10/2002
1Psychotropic Drugs (Psychoactive Drugs)IBA
10/2002
1HLA-DQ Antigens (HLA-DQ)IBA
10/2002

Therapy/Procedure

2Institutionalization (Institutionalized Persons)
12/2014 - 08/2012
1Aftercare (After-Treatment)
01/2014
1Activities of Daily Living (ADL)
10/2013
1Continuous Positive Airway Pressure
01/2011
1Tracheotomy
01/2011