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Irina G Obrosova Selected Research

Peripheral Nervous System Diseases (PNS Diseases)

7/2015Role of Peroxynitrite in the Development of Diabetic Peripheral Neuropathy.
11/2014Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy.
3/2013Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy.
4/2012Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
10/2011Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice.
7/2011Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.
5/2011PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function.
3/2011Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.
9/2010Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
5/2009Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.
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Irina G Obrosova Research Topics

Disease

18Diabetic Neuropathies (Diabetic Neuropathy)
11/2014 - 01/2002
15Peripheral Nervous System Diseases (PNS Diseases)
07/2015 - 01/2002
11Hyperglycemia
09/2013 - 03/2003
11Diabetes Complications
10/2011 - 08/2003
10Hyperalgesia
09/2013 - 01/2005
7Obesity
09/2013 - 12/2006
6Diabetic Nephropathies (Diabetic Nephropathy)
11/2010 - 08/2003
5Inflammation
07/2011 - 01/2009
3Cataract (Cataracts)
06/2012 - 06/2008
3Prediabetic State (Prediabetes)
03/2012 - 01/2010
3Diabetic Retinopathy (Retinopathy, Diabetic)
03/2011 - 03/2003
3Pain (Aches)
10/2009 - 01/2005
2Hyperinsulinism (Hyperinsulinemia)
04/2012 - 03/2012
2Kidney Diseases (Kidney Disease)
03/2012 - 04/2010
2Hypertrophy
10/2011 - 11/2010
2Atrophy
09/2010 - 06/2010
2Ischemia
07/2010 - 01/2009
2Reperfusion Injury
07/2010 - 01/2009
1Glucose Intolerance
09/2013
1Metabolic Diseases (Metabolic Disease)
09/2013
1Hypertriglyceridemia
04/2012
1Dyslipidemias (Dyslipidemia)
04/2012
1Hypercholesterolemia
04/2012
1Polyuria
03/2012
1Chronic Disease (Chronic Diseases)
07/2011
1Weight Gain
09/2010
1Hypertension (High Blood Pressure)
10/2009
1Neuralgia (Stump Neuralgia)
05/2009
1Blindness (Hysterical Blindness)
07/2005
1Renal Insufficiency (Renal Failure)
07/2005
1Anoxia (Hypoxia)
07/2004

Drug/Important Bio-Agent (IBA)

20Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
10/2011 - 08/2003
11Aldehyde Reductase (Aldose Reductase)IBA
04/2012 - 01/2002
9Sorbitol (Yal)FDA Link
06/2012 - 01/2002
8Peroxynitrous Acid (Peroxynitrite)IBA
07/2015 - 01/2005
8Streptozocin (Streptozotocin)FDA Link
03/2013 - 01/2005
7Glucose (Dextrose)FDA LinkGeneric
09/2013 - 11/2005
7Retinaldehyde (Retinal)IBA
06/2012 - 07/2004
7Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA
04/2012 - 10/2007
5fidarestatIBA
07/2010 - 03/2003
4Insulin (Novolin)FDA Link
04/2012 - 07/2005
4Protein Kinases (Protein Kinase)IBA
10/2011 - 07/2005
4Protein Kinase CIBA
03/2011 - 01/2005
3LeptinIBA
10/2009 - 12/2006
3Formaldehyde (Formol)FDA Link
10/2009 - 06/2006
3Superoxides (Superoxide)IBA
11/2005 - 01/2005
2AntioxidantsIBA
11/2014 - 01/2002
2Sodium-Hydrogen AntiporterIBA
08/2013 - 06/2012
2p38 Mitogen-Activated Protein KinasesIBA
06/2012 - 07/2011
2CollagenIBA
03/2012 - 11/2010
24-hydroxy-2-nonenal (4-hydroxynonenal)IBA
05/2011 - 10/2007
2PMI-5011IBA
03/2011 - 01/2010
2polyolIBA
03/2011 - 01/2005
2Poly Adenosine Diphosphate RiboseIBA
11/2010 - 10/2007
2AcidsIBA
09/2010 - 09/2010
2Arachidonic Acid (Vitamin F)IBA
09/2010 - 09/2010
23-nitrotyrosineIBA
06/2010 - 10/2007
2TaurineFDA Link
06/2006 - 01/2005
2NAD (NADH)IBA
06/2006 - 08/2003
1Proteins (Proteins, Gene)IBA
09/2013
1Fatty Acids (Saturated Fatty Acids)IBA
09/2013
1trimethyloxamine (trimethylamine N-oxide)IBA
09/2013
1salubrinalIBA
09/2013
1CCAAT-Enhancer-Binding ProteinsIBA
03/2013
1cariporideIBA
06/2012
1Nonesterified Fatty Acids (NEFA)IBA
04/2012
1Niacin (Nicotinic Acid)FDA LinkGeneric
04/2012
1acipimoxIBA
04/2012
1Mitogen-Activated Protein KinasesIBA
04/2012
1baicaleinIBA
07/2011
18-hydroxy-2'-deoxyguanosineIBA
05/2011
1IsoprostanesIBA
05/2011
1Galactose (Galactopyranose)FDA LinkGeneric
03/2011
1Advanced Glycosylation End ProductsIBA
03/2011
1Fibronectins (Fibronectin)IBA
11/2010
1Blood Glucose (Blood Sugar)IBA
09/2010
1L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)IBA
07/2010
1Biological Markers (Surrogate Marker)IBA
06/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2009
1Leptin ReceptorsIBA
10/2009
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
05/2009
1GPI 15427IBA
03/2008
1Mesylates (Mesylate)IBA
03/2008
1Asp(5)- oxytocin (OXA)IBA
03/2008
1Free RadicalsIBA
08/2007
1Oxidants (Oxidizing Agents)IBA
08/2007
1Endothelin-1 (Endothelin 1)IBA
07/2005
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2005
11,5-isoquinolinediolIBA
07/2004
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2004
1Messenger RNA (mRNA)IBA
07/2004
1Adenosine Diphosphate (ADP)IBA
08/2003
1Nuclear Proteins (Protein, Nuclear)IBA
08/2003
1Endothelins (Endothelin)IBA
08/2003
1Adenosine Diphosphate Ribose (ADP-Ribose)IBA
08/2003
1diacetyldichlorofluoresceinIBA
03/2003
1Reactive Oxygen Species (Oxygen Radicals)IBA
03/2003

Therapy/Procedure

3Amputation
10/2009 - 12/2003