Norihiro Nishimoto Selected Research

Interleukin-6 (Interleukin 6)

09/2007	Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.
02/2007	Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor.
09/2006	Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas.
05/2006	Interleukin-6 in rheumatoid arthritis.
01/2005	[Interleukin-6 in pathogenesis of rheumatoid arthritis]
01/2005	All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice.
10/2004	TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
12/2002	Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
11/2002	Human interleukin-6 induces human herpesvirus-8 replication in a body cavity-based lymphoma cell line.
09/2002	[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]

5	Rheumatoid Arthritis 09/2007 - 06/2003
2	Neoplasms (Cancer) 02/2007 - 10/2004
1	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis) 03/2008
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2007
1	Mesothelioma 09/2006
1	Glomerulonephritis 01/2005
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 10/2004
1	Colonic Neoplasms (Colon Cancer) 10/2004
1	Amyloidosis 06/2004
1	Hematologic Diseases (Blood Diseases) 02/2004
1	Multiple Myeloma 10/2003
1	Giant Lymph Node Hyperplasia (Castleman's Disease) 12/2002
1	Lymphoma (Lymphomas) 11/2002
1	Autoimmune Diseases (Autoimmune Disease) 09/2002
1	Collagen Diseases (Collagen Disease) 09/2002
1	Hypersensitivity (Allergy) 09/2002

10	Interleukin-6 (Interleukin 6)IBA 09/2007 - 09/2002
3	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 10/2004 - 07/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2006 - 06/2003
1	tocilizumabIBA 03/2008
1	rituximab (Mabthera)FDA Link 01/2007
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2005
1	Transforming Growth Factor beta (TGF-beta)IBA 10/2004
1	Monoclonal AntibodiesIBA 02/2004
1	OsteopontinIBA 10/2003