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Kazuaki Niikura Selected Research

Vacuolar Proton-Translocating ATPases (V-Type ATPase)

9/2007Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
12/2005A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
9/2005A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application.
6/2004A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase.

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Kazuaki Niikura Research Topics

Disease

7Bone Resorption
09/2007 - 06/2004
3Bone Diseases (Bone Disease)
04/2007 - 06/2004
2Hypercalcemia (Milk Alkali Syndrome)
04/2007 - 09/2005
1Breast Neoplasms (Breast Cancer)
09/2007
1Neoplasms (Cancer)
09/2007
1Osteolysis
09/2007
1Neoplasm Metastasis (Metastasis)
09/2007
1Rheumatoid Arthritis
04/2007
1Inflammation
04/2007
1Arthritis (Polyarthritis)
04/2007
1Osteopetrosis
04/2006
1Periodontitis
12/2005
1Alveolar Bone Loss
12/2005
1Periodontal Diseases (Periodontal Disease)
12/2005
1Body Weight (Weight, Body)
09/2005

Drug/Important Bio-Agent (IBA)

6Adenosine Triphosphatases (ATPase)IBA
09/2007 - 06/2004
4Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA
09/2007 - 06/2004
22,6- dichloro- N- (3- methyl- 4- (3- methyl- 2- oxo- 1- imidazolidinyl)- 8- quinolinyl)benzamideIBA
09/2007 - 12/2005
2Tretinoin (Retinoic Acid)FDA LinkGeneric
04/2007 - 09/2005
2Interleukin-1 (Interleukin 1)IBA
04/2007 - 09/2005
2Interleukin-6 (Interleukin 6)IBA
04/2007 - 09/2005
2FR 167356IBA
09/2005 - 06/2004
12,6- dichloro- N- (1- (2- (4- morpholinyl)- 2- oxoethyl)- 2- (trifluoromethyl)- 1H- benzimidazol- 4- yl)benzamideIBA
04/2007
1N-Acetylneuraminic Acid (Sialic Acid)IBA
04/2007
1cimadronateIBA
02/2007
1Dihydrotachysterol (AT 10)IBA
02/2007
1Parathyroid Hormone (Parathormone)IBA
02/2007
1apicularen AIBA
02/2007
1apicularen BIBA
02/2007
1Interleukin-1beta (Interleukin 1 beta)IBA
02/2007

Therapy/Procedure

1Oral Administration
12/2005
1Ligation
12/2005