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Ruben Niesvizky Selected Research

Dexamethasone (Maxidex)

12/2015Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma.
1/2015Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma.
12/2014Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: an open-label phase 1/2 study.
12/2014Thalidomide, clarithromycin, lenalidomide and dexamethasone therapy in newly diagnosed, symptomatic multiple myeloma.
10/2013Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma.
4/2013Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma.
3/2013BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma.
12/2012Treatment with lenalidomide and dexamethasone in patients with multiple myeloma and renal impairment.
11/2012Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.
3/2012A review of second primary malignancy in patients with relapsed or refractory multiple myeloma treated with lenalidomide.
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Ruben Niesvizky Research Topics

Disease

55Multiple Myeloma
12/2015 - 03/2002
11Neoplasms (Cancer)
03/2013 - 03/2002
4Lymphoma (Lymphomas)
01/2009 - 02/2006
4Non-Hodgkin Lymphoma (Lymphosarcoma)
04/2008 - 08/2005
3Melanoma (Melanoma, Malignant)
07/2011 - 07/2005
3Disease Progression
07/2009 - 09/2002
3Thrombosis (Thrombus)
07/2008 - 09/2002
2Hematologic Neoplasms (Hematological Malignancy)
10/2013 - 02/2009
2Fever (Fevers)
01/2012 - 04/2009
2Renal Insufficiency (Renal Failure)
01/2012 - 11/2010
2Thromboembolism
01/2010 - 12/2007
2Venous Thromboembolism
01/2010 - 11/2007
2Testicular Neoplasms (Testicular Cancer)
01/2010 - 07/2005
2Fatigue
08/2009 - 04/2009
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
04/2008 - 03/2008
2Waldenstrom Macroglobulinemia (Macroglobulinemia)
04/2003 - 09/2002
1Peripheral Nervous System Diseases (PNS Diseases)
12/2014
1Necrotizing Fasciitis
03/2014
1Dyspnea (Shortness of Breath)
11/2013
1Heart Failure
11/2013
1Neoplasm Metastasis (Metastasis)
07/2012
1Skin Neoplasms (Skin Cancer)
03/2012
1HIV Infections (HIV Infection)
01/2012
1Thrombotic Microangiopathies
01/2012
1Purpura
01/2012
1Inflammation
05/2010
1Diarrhea
08/2009
1Nausea
04/2009
1Hemorrhage
07/2008
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
07/2008
1Acute Promyelocytic Leukemia
07/2008
1Neutropenia
11/2007
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
08/2005
1B-Cell Lymphoma (Lymphoma, B Cell)
08/2005
1Monoclonal Gammopathy of Undetermined Significance
07/2005

Drug/Important Bio-Agent (IBA)

24Dexamethasone (Maxidex)FDA LinkGeneric
12/2015 - 03/2002
21lenalidomide (CC 5013)FDA Link
01/2015 - 09/2007
12bortezomib (Velcade)FDA Link
12/2015 - 11/2005
7Thalidomide (Thalomid)FDA Link
12/2014 - 09/2002
7Clarithromycin (Biaxin)FDA LinkGeneric
12/2014 - 09/2002
6carfilzomibIBA
10/2015 - 01/2013
6Proteasome Endopeptidase Complex (Proteasome)IBA
01/2015 - 11/2012
3Cyclin-Dependent Kinase 4IBA
08/2012 - 12/2005
3AntigensIBA
07/2011 - 07/2005
3Prednisone (Sone)FDA LinkGeneric
03/2010 - 03/2008
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
07/2008 - 03/2008
2CyclinsIBA
12/2015 - 12/2005
2milatuzumabIBA
11/2013 - 01/2009
2Melphalan (Alkeran)FDA LinkGeneric
05/2013 - 03/2010
2thymidine 5'-triphosphate (TTP)IBA
01/2012 - 04/2009
2Procarbazine (Matulane)FDA Link
05/2008 - 03/2008
2Etoposide (VP 16)FDA LinkGeneric
05/2008 - 03/2008
2Monoclonal AntibodiesIBA
04/2008 - 08/2005
2rituximab (Mabthera)FDA Link
04/2008 - 08/2005
2IodineIBA
02/2006 - 08/2005
1Phosphotransferases (Kinase)IBA
12/2015
1pomalidomideIBA
05/2014
1Immunoglobulin G (IgG)IBA
03/2014
1CreatinineIBA
11/2013
1bendamustineFDA Link
05/2013
1DNA (Deoxyribonucleic Acid)IBA
11/2012
1Histone Deacetylase InhibitorsIBA
01/2011
1romidepsin (FK228)FDA Link
01/2011
1EnzymesIBA
05/2010
1dacetuzumabIBA
05/2010
1Proteins (Proteins, Gene)IBA
01/2010
1vorinostat (suberoylanilide hydroxamic acid)FDA Link
08/2009
1tranilast (N 5')IBA
08/2009
1oblimersen (G3139)IBA
04/2009
1Transforming Growth Factor beta1 (TGF beta 1)IBA
02/2009
1Transforming Growth Factor beta (TGF-beta)IBA
02/2009
1AutoantibodiesIBA
07/2008
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
12/2007
16- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- oneIBA
08/2006
1Cyclin D1IBA
12/2005
1Retinoblastoma ProteinIBA
12/2005
1Cyclin D2IBA
12/2005
1Cyclin-Dependent Kinase 6IBA
12/2005
1fludarabineIBA
08/2005
1hLL2 agent (epratuzumab)IBA
08/2005
1Messenger RNA (mRNA)IBA
07/2005
1Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
04/2005
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
04/2005
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
04/2005
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
04/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2005

Therapy/Procedure

6Drug Therapy (Chemotherapy)
10/2011 - 03/2002
5Stem Cell Transplantation
02/2014 - 08/2009
3Heterologous Transplantation (Xenotransplantation)
08/2012 - 08/2006
2Immunotherapy
11/2013 - 07/2005
2Hematopoietic Stem Cell Mobilization
03/2013 - 07/2008
2Combination Drug Therapy (Combination Chemotherapy)
05/2008 - 03/2008
1Radiotherapy
07/2012
1Brachytherapy
07/2012
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2012
1Transplants (Transplant)
03/2010
1Salvage Therapy
06/2009
1Immunomodulation
12/2008
1Splenectomy
04/2008
1Radioimmunotherapy
08/2005