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Kathy Nicholls Selected Research

Galactosidases

1/2015Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase.
12/2013Analysis of left ventricular mass in untreated men and in men treated with agalsidase-β: data from the Fabry Registry.
1/2013Migalastat HCl reduces globotriaosylsphingosine (lyso-Gb3) in Fabry transgenic mice and in the plasma of Fabry patients.
1/2012Safety and pharmacodynamic effects of a pharmacological chaperone on α-galactosidase A activity and globotriaosylceramide clearance in Fabry disease: report from two phase 2 clinical studies.
10/2011Targeted urine microscopy in Anderson-Fabry disease: a cheap, sensitive and specific diagnostic technique.
11/2010Effects of enzyme replacement therapy in Fabry disease--a comprehensive review of the medical literature.
11/2010Therapeutic goals in the treatment of Fabry disease.

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Kathy Nicholls Research Topics

Disease

14Fabry Disease (Fabry's Disease)
01/2015 - 01/2005
3Chronic Kidney Failure (Chronic Renal Failure)
05/2009 - 03/2006
2Proteinuria
02/2014 - 05/2009
1Nephrotic Syndrome (Syndrome, Nephrotic)
07/2015
1Gastroenteritis
02/2014
1Herpes Zoster
02/2014
1Lupus Nephritis
02/2014
1Infection
02/2014
1Kidney Diseases (Kidney Disease)
12/2013
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2013
1Renal Insufficiency (Renal Failure)
07/2013
1Albuminuria
10/2011
1Myocardial Infarction
03/2011
1Heart Failure
03/2011
1Pain (Aches)
11/2010
1Neuralgia (Stump Neuralgia)
11/2010
1Atherosclerosis
03/2006
1Atherosclerotic Plaque (Atheroma)
03/2006

Drug/Important Bio-Agent (IBA)

7GalactosidasesIBA
01/2015 - 11/2010
5agalsidase alfaIBA
01/2015 - 05/2009
3globotriaosylceramide (globotriosylceramide)IBA
12/2013 - 01/2012
3alpha-Galactosidase (Beano)IBA
03/2011 - 01/2005
2agalsidase betaFDA Link
01/2015 - 01/2012
2CreatinineIBA
02/2014 - 10/2011
1HLA-DQA1 (HLA DQA1)IBA
07/2015
1GlucocorticoidsIBA
02/2014
1mycophenolate mofetil (Cellcept)FDA LinkGeneric
02/2014
1abatacept (BELATACEPT)FDA Link
02/2014
1Biological Markers (Surrogate Marker)IBA
12/2013
12'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA
05/2009
1Folic Acid (Vitamin M)FDA LinkGeneric
03/2006

Therapy/Procedure

7Enzyme Replacement Therapy
01/2015 - 05/2009
2Kidney Transplantation
07/2013 - 05/2006
1Transplants (Transplant)
07/2013