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Benjamin G Neel Selected Research

Tyrosine (L-Tyrosine)

1/2015Differential regulation of FGFR3 by PTPN1 and PTPN2.
3/2012Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
11/2011Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
9/2011Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".
7/2011SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.
11/2010A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
4/2009Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
6/2008The tyrosine phosphatase Shp2 (PTPN11) in cancer.
1/2007Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
8/2006Neuronal PTP1B regulates body weight, adiposity and leptin action.
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Benjamin G Neel Research Topics

Disease

25Neoplasms (Cancer)
09/2015 - 09/2002
13Obesity
01/2015 - 04/2002
10Noonan Syndrome (Female Pseudo-Turner Syndrome)
11/2015 - 08/2004
7Insulin Resistance
07/2014 - 06/2004
5Hypersensitivity (Allergy)
09/2014 - 04/2002
4LEOPARD Syndrome (Syndrome, LEOPARD)
01/2014 - 01/2010
4Inflammation
03/2013 - 01/2007
3Neurofibromatosis 1 (Neurofibromatosis Type I)
08/2014 - 01/2010
3Ovarian Neoplasms (Ovarian Cancer)
01/2013 - 04/2011
3Breast Neoplasms (Breast Cancer)
10/2011 - 08/2002
3Leukemia
02/2007 - 03/2004
2Weight Loss (Weight Reduction)
01/2015 - 09/2014
2Weight Gain
09/2014 - 11/2011
2Body Weight (Weight, Body)
01/2012 - 08/2006
2Tics (Tic)
04/2011 - 09/2010
2Juvenile Myelomonocytic Leukemia
11/2010 - 04/2009
2Melanoma (Melanoma, Malignant)
09/2010 - 09/2002
1Adenocarcinoma
08/2015
1Fibrosarcoma
05/2015
1Sarcoma (Soft Tissue Sarcoma)
05/2015
1Multiple Myeloma
01/2015
1Coffin-Lowry Syndrome (Syndrome, Coffin-Lowry)
08/2014
1Hyperglycemia
07/2014
1Disease Progression
07/2014
1Hypertriglyceridemia
07/2014
1Osteochondroma (Osteocartilaginous Exostosis)
01/2013
1Chondroma (Enchondroma)
01/2013
1Anoxia (Hypoxia)
01/2012
1Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
03/2011
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2011
1Lung Neoplasms (Lung Cancer)
05/2010
1Costello Syndrome
01/2010
1Glucose Intolerance
03/2009
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
03/2008
1Carcinoma (Carcinomatosis)
03/2008
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2008
1Neuroblastoma
03/2008
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
03/2008
1Glomerulonephritis
07/2007
1Mental Retardation (Idiocy)
04/2007
1Learning Disorders (Learning Disability)
04/2007

Drug/Important Bio-Agent (IBA)

12Tyrosine (L-Tyrosine)FDA Link
01/2015 - 08/2002
11Insulin (Novolin)FDA Link
01/2015 - 04/2002
10Protein Tyrosine PhosphatasesIBA
01/2015 - 04/2002
8LeptinIBA
01/2015 - 04/2002
8Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
07/2013 - 06/2004
7Phosphotransferases (Kinase)IBA
11/2015 - 01/2007
6Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
03/2012 - 01/2007
56-pyruvoyltetrahydropterin synthase (PTPS)IBA
07/2014 - 06/2004
4Proteins (Proteins, Gene)IBA
11/2015 - 07/2005
3Epidermal Growth Factor Receptor (EGF Receptor)IBA
08/2015 - 01/2003
3Glucose (Dextrose)FDA LinkGeneric
07/2014 - 01/2012
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2015 - 03/2004
2Adenocarcinoma of lungIBA
08/2015 - 03/2008
2GTP Phosphohydrolases (GTPases)IBA
05/2015 - 03/2013
2Growth Hormone (Somatotropin)IBA
07/2014 - 03/2012
2Parathyroid Hormone-Related ProteinIBA
07/2013 - 01/2013
2Insulin ReceptorIBA
01/2012 - 08/2007
2Sirolimus (Rapamycin)FDA Link
03/2011 - 03/2004
2Messenger RNA (mRNA)IBA
05/2010 - 08/2002
2DNA (Deoxyribonucleic Acid)IBA
03/2008 - 07/2007
1RNA (Ribonucleic Acid)IBA
09/2015
1ral Guanine Nucleotide Exchange FactorIBA
05/2015
1GuanineIBA
05/2015
1raf KinasesIBA
05/2015
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2015
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2015
1PhosphotyrosineIBA
01/2015
1Nonsense Codon (Nonsense Mutation)IBA
08/2014
1Insulin-Like Growth Factor I (IGF-1)IBA
07/2014
1Non-alcoholic Fatty Liver DiseaseIBA
05/2014
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
05/2014
1Biological Markers (Surrogate Marker)IBA
04/2013
1GTP-Binding Proteins (G-Protein)IBA
03/2013
1Guanosine Triphosphate (GTP)IBA
03/2013
1Folic Acid (Vitamin M)FDA LinkGeneric
01/2013
1Hetastarch (Pentastarch)FDA Link
10/2012
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
10/2012
1Small Interfering RNA (siRNA)IBA
02/2012
1Complement System Proteins (Complement)IBA
02/2012
1histone methyltransferaseIBA
07/2011
1Cyclin D1IBA
07/2011
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2011
1Fluorouracil (Carac)FDA LinkGeneric
01/2011
1Cisplatin (Platino)FDA LinkGeneric
01/2011
1Heme (Haem)IBA
01/2011
1Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)IBA
01/2011
1IronIBA
01/2011
1Paclitaxel (Taxol)FDA LinkGeneric
01/2011
1Aldehyde DehydrogenaseIBA
09/2010
1gefitinib (Iressa)FDA Link
05/2010
1Legius syndromeIBA
01/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2008
1Protein Kinases (Protein Kinase)IBA
03/2008
1AntibodiesIBA
07/2007
1Immunoglobulins (Immunoglobulin)IBA
07/2007
1Antigen-Antibody Complex (Immune Complex)IBA
07/2007
1Interferon-gamma (Interferon, gamma)IBA
01/2007

Therapy/Procedure

8Heterologous Transplantation (Xenotransplantation)
08/2015 - 09/2010
1Drug Therapy (Chemotherapy)
01/2011