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Keiichi I Nakayama Selected Research

Cyclin-Dependent Kinase Inhibitor p27

3/2010Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.
11/2008A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
12/2006Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.
8/2005Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.

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Keiichi I Nakayama Research Topics

Disease

19Neoplasms (Cancer)
02/2015 - 10/2002
3Leukemia
03/2013 - 08/2004
3Neoplasm Metastasis (Metastasis)
06/2012 - 11/2007
3Atherosclerosis
11/2011 - 12/2004
3Obesity
07/2010 - 01/2007
3Retinoblastoma (Glioblastoma, Retinal)
11/2006 - 08/2005
2Infection
05/2014 - 07/2006
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
03/2013 - 03/2013
2Bone Resorption
01/2013 - 12/2012
2Breast Neoplasms (Breast Cancer)
05/2012 - 10/2003
2Fibrosis (Cirrhosis)
01/2012 - 01/2012
2Fatty Liver
09/2011 - 10/2002
2Neurodegenerative Diseases (Neurodegenerative Disease)
07/2010 - 05/2010
2Lymphoma (Lymphomas)
03/2010 - 12/2004
2Neointima
11/2009 - 12/2004
2Pheochromocytoma
05/2009 - 12/2004
2Bacterial Infections (Bacterial Infection)
05/2009 - 07/2006
2Atopic Dermatitis (Atopic Eczema)
05/2009 - 12/2003
2Glucose Intolerance
01/2007 - 01/2007
2Lung Diseases (Lung Disease)
01/2007 - 05/2006
2Inflammation
01/2007 - 01/2003
2Retinal Detachment (Retinal Detachments)
03/2006 - 05/2004
1Prostatic Neoplasms (Prostate Cancer)
01/2015
1Osteolysis
01/2013
1Osteoporosis
09/2012
1Adenocarcinoma
06/2012
1Corneal Opacity
01/2012
1Atherosclerotic Plaque (Atheroma)
11/2011
1Hydrocephalus (Hydrocephaly)
10/2011
1Acute Liver Failure (Fulminant Hepatic Failure)
09/2011
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
03/2011
1Thrombosis (Thrombus)
01/2011
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
01/2011
1Burkitt Lymphoma (Burkitt's Lymphoma)
03/2010
1Genetic Translocation (Chromosomal Translocation)
03/2010
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2009
1Stomach Neoplasms (Stomach Cancer)
05/2009
1Heart Failure
11/2008
1Reperfusion Injury
11/2008
1Myocardial Infarction
11/2008

Drug/Important Bio-Agent (IBA)

13UbiquitinIBA
03/2013 - 05/2004
6Phosphotransferases (Kinase)IBA
01/2012 - 10/2003
5CyclinsIBA
02/2012 - 10/2003
4Cyclin-Dependent Kinase Inhibitor p27IBA
03/2010 - 08/2005
4Cathepsin EIBA
05/2009 - 12/2003
3LigasesIBA
05/2012 - 05/2004
3Proteins (Proteins, Gene)IBA
03/2011 - 07/2005
3Messenger RNA (mRNA)IBA
04/2010 - 08/2007
3Cyclin D1IBA
11/2008 - 05/2004
3AntibodiesIBA
03/2006 - 04/2002
2Interleukin-12 (IL 12)IBA
05/2014 - 01/2003
2Protein Kinase CIBA
01/2013 - 01/2007
2Cathepsin KIBA
01/2013 - 12/2012
2Estrogens (Estrogen)FDA Link
09/2012 - 10/2003
2Glucose (Dextrose)FDA LinkGeneric
05/2012 - 06/2007
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2012 - 03/2011
2Serine (L-Serine)FDA Link
11/2011 - 03/2006
2Cyclin EIBA
03/2011 - 08/2006
2Nerve Growth Factor (NGF)IBA
05/2009 - 12/2004
2Proteasome Endopeptidase Complex (Proteasome)IBA
05/2008 - 02/2004
2Insulin (Novolin)FDA Link
01/2007 - 01/2007
2AsbestosIBA
01/2007 - 05/2006
2Proliferating Cell Nuclear Antigen (PCNA)IBA
03/2006 - 05/2004
2Threonine (L-Threonine)FDA Link
03/2006 - 08/2005
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
02/2015
1Histones (Histone)IBA
01/2015
1Lysine (L-Lysine)FDA Link
01/2015
1imatinib (Gleevec)FDA Link
03/2013
1rottlerinIBA
01/2013
1Protein Kinase C-deltaIBA
12/2012
1Aldehyde DehydrogenaseIBA
09/2012
1AcetaldehydeIBA
09/2012
1tebufenozide (Mimic)IBA
06/2012
1Calcibiotic Root Canal SealerIBA
06/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2012
1trastuzumab (Herceptin)FDA Link
05/2012
1AlkaliesIBA
01/2012
1DesminIBA
01/2012
1CollagenIBA
01/2012
1Protein Kinases (Protein Kinase)IBA
11/2011
1ApolipoproteinsIBA
11/2011
1Aminobutyric Acids (Aminobutyric Acid)IBA
10/2011
1IronIBA
09/2011
1Cullin 1IBA
03/2011
1sorafenib (BAY 43-9006)FDA Link
03/2011
1Glycogen Synthase Kinase 3IBA
03/2011
1ABT-737IBA
03/2011
1Antiphospholipid AntibodiesIBA
01/2011
1Peptide Elongation Factors (Elongation Factor)IBA
07/2010
1GTP Phosphohydrolases (GTPases)IBA
05/2010
1Immunoglobulins (Immunoglobulin)IBA
03/2010
1TYK2 Kinase (Tyrosine Kinase 2)IBA
12/2009
1oligodendrocyte-myelin glycoproteinIBA
12/2009
1Cyclin-Dependent Kinases (cdk Proteins)IBA
09/2008

Therapy/Procedure

2Transplants (Transplant)
11/2009 - 11/2007
2Aftercare (After-Treatment)
03/2006 - 12/2004
1Castration
01/2015
1Homologous Transplantation (Allograft)
06/2012
1Stents
11/2009
1Ligation
11/2008