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Hiroshi Miyazaki Selected Research

Thrombopoietin (c-mpl Ligand)

2/2008Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor.
3/2006Thrombopoietin in postoperative thrombocytopenia following living donor hepatectomy.
8/2005Determination of thrombopoietin-derived peptides recognized by both cellular and humoral immunities in healthy donors and patients with thrombocytopenia.
4/2005Thrombopoietin in the cerebrospinal fluid of patients with aseptic and bacterial meningitis.
6/2004Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin.
8/2003Thrombopoietin-producing hepatocellular carcinoma.
5/2003Thrombopoietin upregulates nucleolin mRNA and protein in thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO.
8/2002Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia.
3/2002Elevation of serum thrombopoietin precedes thrombocytosis in acute infections.

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Hiroshi Miyazaki Research Topics

Disease

11Neoplasms (Cancer)
01/2014 - 01/2003
6Neoplasm Metastasis (Metastasis)
02/2012 - 03/2006
6Thrombocytopenia (Thrombopenia)
04/2009 - 08/2002
5Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/2010 - 08/2005
4Thrombocytosis (Thrombocythemia)
06/2004 - 03/2002
3Head and Neck Neoplasms (Head and Neck Cancer)
04/2010 - 03/2007
3Hypertrophy
12/2006 - 08/2003
2Ischemia
01/2014 - 01/2003
2Insulin Resistance
01/2014 - 01/2008
2Frontotemporal Lobar Degeneration (Semantic Dementia)
06/2012 - 10/2010
2Infection
02/2010 - 03/2002
2Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
10/2002 - 08/2002
1Hyperglycemia
01/2014
1Fatty Liver
01/2014
1Infarction
01/2014
1Cerebral Infarction
01/2014
1Hemorrhage
01/2014
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2014
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2014
1Cardiovascular Diseases (Cardiovascular Disease)
01/2014
1Fibrosis (Cirrhosis)
01/2014
1Atherosclerosis
09/2013
1Stroke (Strokes)
01/2011
1Obesity
01/2011
1Dyslipidemias (Dyslipidemia)
01/2011
1Atrophy
10/2010
1Anemia
05/2010
1Lymphoma (Lymphomas)
02/2010
1Non-Hodgkin Lymphoma (Lymphosarcoma)
02/2010
1Hepatitis B
02/2010
1Thrombosis (Thrombus)
09/2009
1Congenital Abnormalities (Deformity)
04/2009
1Glioblastoma (Glioblastoma Multiforme)
04/2009
1Pancytopenia
04/2009
1Acute Promyelocytic Leukemia
02/2009
1Crohn Disease (Crohn's Disease)
02/2009
1Cardiomyopathies (Cardiomyopathy)
01/2009
1Breast Neoplasms (Breast Cancer)
01/2009
1Choline Deficiency
01/2009
1Takotsubo Cardiomyopathy
01/2009
1Papillary Carcinoma
12/2007
1Diarrhea
10/2007

Drug/Important Bio-Agent (IBA)

9Thrombopoietin (c-mpl Ligand)IBA
02/2008 - 03/2002
6Proteins (Proteins, Gene)IBA
05/2013 - 04/2005
4AntibodiesIBA
10/2010 - 08/2002
4Epidermal Growth Factor (EGF)IBA
01/2009 - 08/2005
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2013 - 03/2007
3ChemokinesIBA
04/2010 - 03/2007
3Transforming Growth Factor beta (TGF-beta)IBA
09/2008 - 03/2006
3polyethylene glycol-recombinant human megakaryocyte growth and development factor (PEG-MGDF)IBA
08/2005 - 10/2002
2Glucose (Dextrose)FDA LinkGeneric
01/2014 - 01/2014
2Vitamin EFDA LinkGeneric
01/2014 - 01/2009
2Insulin (Novolin)FDA Link
01/2014 - 03/2005
2CytokinesIBA
05/2013 - 03/2007
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
05/2013 - 03/2007
2protein TDP-43 (TDP-43)IBA
06/2012 - 10/2010
2Vitamin A (Retinol)FDA LinkGeneric
01/2011 - 01/2008
2Immunoglobulin G (IgG)IBA
02/2008 - 10/2002
2Phenylephrine (Neo-Synephrine)FDA LinkGeneric
03/2005 - 08/2003
2Caveolin 3IBA
03/2005 - 08/2003
2Thrombopoietin ReceptorsIBA
09/2004 - 08/2002
1Non-alcoholic Fatty Liver DiseaseIBA
01/2014
1phenylmethylpyrazoloneIBA
01/2014
1N,N-dimethylarginine (asymmetric dimethylarginine)IBA
09/2013
1Nitric Oxide Synthase (NO Synthase)IBA
09/2013
1Advanced Glycosylation End ProductsIBA
09/2013
1Transforming Growth Factors (Transforming Growth Factor)IBA
05/2013
1Tissue Plasminogen Activator (Alteplase)FDA Link
01/2011
1UbiquitinIBA
10/2010
1DNA-Binding Proteins (DNA Binding Protein)IBA
10/2010
1phenylhydrazine (phenylhydrazine hydrochloride)IBA
05/2010
1Messenger RNA (mRNA)IBA
05/2010
1Small Interfering RNA (siRNA)IBA
04/2010
1Vascular Endothelial Growth Factor CIBA
04/2010
1Vincristine (Oncovin)FDA LinkGeneric
02/2010
1DNA (Deoxyribonucleic Acid)IBA
02/2010
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2010
1rituximab (Mabthera)FDA Link
02/2010
1Prednisone (Sone)FDA LinkGeneric
02/2010
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2010
1Plasminogen Activator Inhibitor 1IBA
09/2009
1beta CateninIBA
04/2009
1temozolomide (Temodar)FDA LinkGeneric
04/2009
1Tretinoin (Retinoic Acid)FDA LinkGeneric
02/2009
1Methionine (L-Methionine)FDA Link
01/2009
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2009
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2009
1Adrenocorticotropic Hormone (ACTH)FDA Link
01/2009
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
01/2009
1Interleukin-8 (Interleukin 8)IBA
10/2008
1VimentinIBA
09/2008
1Keratins (Keratin)IBA
09/2008
1beta Carotene (Betacarotene)FDA Link
01/2008
1Retinaldehyde (Retinal)IBA
01/2008
1Neutralizing AntibodiesIBA
10/2007

Therapy/Procedure

1Intraperitoneal Injections
01/2014
1Drug Therapy (Chemotherapy)
02/2010
1Radiotherapy
04/2009
1Platelet Transfusion (Blood Platelet Transfusions)
04/2009
1Thyroidectomy
12/2007