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Kenichi Mishima Selected Research

Brain Ischemia (Cerebral Ischemia)

10/2012ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury.
1/2012Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors.
4/2011Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia.
1/2011Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia.
9/2010Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia.
7/2010Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
4/2010Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia.
4/2010Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice.
2/2010ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.
10/2009Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism.
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Kenichi Mishima Research Topics

Disease

30Brain Ischemia (Cerebral Ischemia)
10/2012 - 01/2003
17Ischemia
10/2012 - 12/2002
11Alzheimer Disease (Alzheimer's Disease)
07/2013 - 12/2002
8Dementia (Dementias)
03/2014 - 10/2003
6Memory Disorders (Memory Loss)
08/2012 - 01/2006
6Cerebral Infarction
09/2009 - 01/2003
6Anoxia (Hypoxia)
11/2005 - 10/2002
5Stroke (Strokes)
10/2015 - 04/2010
5Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
09/2008 - 10/2005
4Brain Injuries (Brain Injury)
10/2015 - 03/2008
4Infarction
12/2008 - 10/2004
4Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
03/2007 - 12/2003
3Hypertension (High Blood Pressure)
04/2012 - 09/2010
3Amyloid Plaque
07/2010 - 05/2005
3Hypothermia
01/2008 - 05/2004
3Catalepsy
01/2008 - 11/2006
3Tremor (Tremors)
01/2008 - 01/2006
2Cleidocranial Dysplasia (Cleidocranial Dysostosis)
02/2015 - 01/2014
2Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
03/2013 - 07/2012
2Inflammation
10/2012 - 03/2005
2Cerebrovascular Disorders (Cerebrovascular Occlusion)
09/2007 - 03/2007
2Schizophrenia (Dementia Praecox)
12/2006 - 02/2003
1Hemorrhage
10/2015
1Cerebral Hemorrhage
10/2015
1Neurofibromatosis 2 (Neurofibromatosis Type II)
10/2015
1Intracranial Vasospasm
12/2014
1Colitis
11/2014
1Adenocarcinoma
11/2014
1Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
01/2014
1Congenital Abnormalities (Deformity)
11/2013
1Fibrosis (Cirrhosis)
10/2013
1Myocardial Infarction
10/2013
1Campomelic Dysplasia
10/2013
1Transient Ischemic Attack
07/2013
1Achondroplasia
01/2013
1Chondrosarcoma
01/2013
1Thanatophoric Dysplasia (Dwarfism, Thanatophoric)
01/2013
1Heterotopic Ossification (Ectopic Ossification)
01/2013
1Motion Sickness (Airsickness)
01/2013
1Myositis Ossificans
01/2013
1Encephalitis (Encephalitis, Rasmussen)
10/2012

Drug/Important Bio-Agent (IBA)

9Tetrahydrocannabinol (THC)FDA LinkGeneric
02/2008 - 10/2004
8Amyloid (Amyloid Fibrils)IBA
07/2013 - 12/2002
7HMGB1 Protein (HMG1)IBA
10/2015 - 03/2008
7CannabidiolIBA
09/2009 - 10/2004
6Acetylcholine (Acetylcholine Chloride)FDA Link
01/2009 - 12/2002
5Yi-Gan SanIBA
03/2014 - 03/2009
3von Willebrand FactorIBA
10/2015 - 02/2010
3glucuronyl glucosamine glycan sulfate (Vessel)IBA
07/2013 - 09/2004
3telmisartan (Micardis)FDA Link
01/2012 - 10/2009
3Serotonin (5 Hydroxytryptamine)IBA
04/2011 - 06/2007
3Glutamic Acid (Glutamate)FDA Link
04/2010 - 04/2004
35-HT1A Serotonin ReceptorIBA
09/2008 - 10/2005
3Scopolamine (Hyoscine)FDA Link
01/2008 - 01/2005
3theanineIBA
01/2008 - 06/2004
3OxotremorineIBA
01/2008 - 01/2006
2Transcription Factors (Transcription Factor)IBA
02/2015 - 01/2014
2Dynamin IIBA
07/2013 - 07/2010
2Protein Isoforms (Isoforms)IBA
12/2012 - 01/2003
2Type 1 Angiotensin ReceptorIBA
01/2012 - 09/2010
2donepezil (Aricept)FDA LinkGeneric
01/2011 - 06/2006
2PPAR gammaIBA
09/2010 - 10/2009
2SynaptophysinIBA
07/2010 - 04/2010
2Kangen-karyuIBA
04/2010 - 03/2009
2olanzapine (Zyprexa)FDA Link
09/2008 - 02/2008
2Antipsychotic Agents (Antipsychotics)IBA
09/2008 - 10/2005
2Haloperidol (Haldol)FDA LinkGeneric
02/2008 - 10/2005
2nilvadipine (Escor)IBA
04/2007 - 10/2003
2Amlodipine (Norvasc)FDA LinkGeneric
04/2007 - 10/2003
2CB1 Cannabinoid Receptor (CB1 Receptor)IBA
03/2007 - 10/2004
2AMPA Receptors (AMPA Receptor)IBA
01/2007 - 01/2005
2N-Methylaspartate (NMDA)IBA
01/2004 - 12/2002
1Tissue Plasminogen Activator (Alteplase)FDA Link
10/2015
1Macrodactyly of the footIBA
10/2015
1Glutamine (L-Glutamine)FDA Link
02/2015
1salicylhydroxamic acid (SHAM)IBA
12/2014
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
11/2014
1DNA (Deoxyribonucleic Acid)IBA
11/2014
1Dextrans (Dextran)FDA Link
11/2014
1InterleukinsIBA
11/2014
1Toll-Like Receptors (Toll-Like Receptor)IBA
11/2014
1TeicoplaninIBA
01/2014
1Ischiopatellar dysplasiaIBA
10/2013
1C-Reactive ProteinIBA
03/2013
1procalcitoninIBA
03/2013
1Interleukin-6 (Interleukin 6)IBA
03/2013
1Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
01/2013
1Meclizine (Meclozine)FDA LinkGeneric
01/2013
1perhexiline maleateIBA
01/2013
1Histamine (Histamine Dihydrochloride)FDA Link
01/2013
1Carbon MonoxideIBA
10/2012
1Glycoproteins (Glycoprotein)IBA
10/2012
1MagnesiumIBA
07/2012
1PropaneIBA
04/2011

Therapy/Procedure

3Oral Administration
11/2014 - 04/2010
2Drug Repositioning
01/2013 - 01/2013
1Osteotomy
11/2013
1Homologous Transplantation (Allograft)
10/2013
1Transplantation (Transplant Recipients)
10/2013
1Hemodilution
04/2012