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Oscar Millet Selected Research

Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)

11/2014Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria.
11/2013Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria.
4/2011Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R.
1/2011Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase: molecular basis of congenital erythropoietic porphyria.
1/2009Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability.

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Oscar Millet Research Topics

Disease

5Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)
11/2014 - 01/2009
1Hemolytic Anemia
11/2013

Drug/Important Bio-Agent (IBA)

5Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA
11/2014 - 01/2009
1Proteasome Endopeptidase Complex (Proteasome)IBA
11/2013
1Heme (Haem)IBA
01/2011