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Steven A Middleton Selected Research

JNJ-7706621

10/2006Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
10/2005The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.

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Steven A Middleton Research Topics

Disease

10Neoplasms (Cancer)
07/2012 - 09/2004
5Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
01/2008 - 03/2007
2Melanoma (Melanoma, Malignant)
07/2005 - 06/2005
1Neuroblastoma
04/2015
1Liposarcoma
11/2012
1Carcinoma (Carcinomatosis)
10/2006
1Retinoblastoma (Glioblastoma, Retinal)
10/2005
1Pain (Aches)
03/2005

Drug/Important Bio-Agent (IBA)

5Phosphotransferases (Kinase)IBA
02/2008 - 09/2004
4Adrenergic Antagonists (Antiadrenergic Agents)IBA
01/2008 - 06/2007
4alpha-1 Adrenergic Receptors (alpha 1 Adrenergic Receptor)IBA
01/2008 - 03/2007
3Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
07/2005 - 09/2004
2Doxorubicin (Adriamycin)FDA LinkGeneric
04/2015 - 09/2004
2Cyclin-Dependent Kinases (cdk Proteins)IBA
10/2006 - 10/2005
2JNJ-7706621IBA
10/2006 - 10/2005
2aurora kinase (aurora A kinase)IBA
10/2006 - 10/2005
1Tumor Suppressor Protein p14ARF (p14ARF)IBA
04/2015
1Cisplatin (Platino)FDA LinkGeneric
04/2015
1temozolomide (Temodar)FDA LinkGeneric
04/2015
1Topotecan (Hycamtin)FDA LinkGeneric
04/2015
1Busulfan (Busulfex)FDA Link
04/2015
12,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
07/2012
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
07/2012
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
04/2009
1pyrimidineIBA
04/2009
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
04/2009
1Tyrosine (L-Tyrosine)FDA Link
02/2008
1JNJ 28871063IBA
02/2008
1benzocycloheptapyridineIBA
08/2007
1PDGF receptor tyrosine kinaseIBA
12/2005
1platelet-derived growth factor BB (becaplermin)FDA Link
12/2005
1Aniline CompoundsIBA
12/2005
1tyrosine receptor (receptor, tyrosine)IBA
12/2005
1CDC2 Protein Kinase (Protein p34cdc2)IBA
10/2005
1P-GlycoproteinIBA
10/2005
1A 17 (A-17)IBA
03/2005
1nociceptinIBA
03/2005
14- (4- (1- Amino- 1- methylethyl)phenyl)- 2- (4- (2- morpholin- 4- yl- ethyl)phenylamino)pyrimidine- 5- carbonitrileIBA
09/2004
1Paclitaxel (Taxol)FDA LinkGeneric
09/2004

Therapy/Procedure

7Heterologous Transplantation (Xenotransplantation)
02/2008 - 09/2004
2Drug Therapy (Chemotherapy)
04/2015 - 11/2012
1Aftercare (After-Treatment)
09/2004