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Takeshi Maruo Selected Research

Leiomyoma (Uterine Fibroids)

9/2011Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas.
11/2010Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system.
5/2010Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth.
4/2008Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
3/2008Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells.
12/2007Comparative effects of SPRM asoprisnil (J867) on proliferation, apoptosis, and the expression of growth factors in cultured uterine leiomyoma cells and normal myometrial cells.
10/2007Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells.
6/2007Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas.
5/2007Concentration-dependent effects of a selective estrogen receptor modulator raloxifene on proliferation and apoptosis in human uterine leiomyoma cells cultured in vitro.
4/2007Progesterone and progesterone receptor modulator in uterine leiomyoma growth.
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Takeshi Maruo Research Topics

Disease

24Leiomyoma (Uterine Fibroids)
09/2011 - 03/2002
9Endometriosis (Adenomyosis)
01/2007 - 02/2004
6Neoplasms (Cancer)
10/2008 - 08/2002
4Menorrhagia
09/2011 - 11/2003
3Myoma
11/2010 - 11/2003
2Thrombosis (Thrombus)
08/2015 - 01/2011
2Atherosclerosis
11/2008 - 01/2005
2Threatened Abortion
12/2007 - 11/2004
2Premature Obstetric Labor (Premature Labor)
12/2007 - 06/2002
2Endometrial Neoplasms (Endometrial Cancer)
05/2007 - 10/2006
2Spontaneous Abortion (Miscarriage)
11/2004 - 06/2002
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2004 - 04/2003
1Myocardial Infarction
08/2015
1Death (Near-Death Experience)
08/2015
1Thrombocytopenia (Thrombopenia)
01/2012
1Myocarditis (Carditis)
01/2012
1Hypersensitivity (Allergy)
01/2011
1Hypertension (High Blood Pressure)
11/2008
1Carcinoma (Carcinomatosis)
10/2008
1Habitual Abortion (Recurrent Miscarriage)
12/2007
1Pre-Eclampsia (Preeclampsia)
04/2007
1Infarction
02/2007
1Ascites
01/2007
1Virilism (Virilization)
07/2006
1Brenner Tumor
07/2006
1Postpartum Hemorrhage
01/2006
1Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis)
11/2005
1Choriocarcinoma
08/2005

Drug/Important Bio-Agent (IBA)

13Progesterone Receptors (Progesterone Receptor)IBA
11/2010 - 04/2004
11ProgesteroneFDA LinkGeneric
11/2010 - 08/2002
9Epidermal Growth Factor (EGF)IBA
11/2010 - 11/2003
8asoprisnilIBA
09/2011 - 04/2006
7ulipristalIBA
09/2011 - 02/2005
7Proliferating Cell Nuclear Antigen (PCNA)IBA
11/2010 - 03/2002
7Messenger RNA (mRNA)IBA
03/2008 - 03/2002
7Insulin-Like Growth Factor I (IGF-1)IBA
12/2007 - 06/2002
6Estrogens (Estrogen)FDA Link
05/2010 - 04/2004
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2010 - 09/2006
4AdrenomedullinIBA
11/2010 - 04/2003
4CollagenIBA
11/2010 - 03/2008
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2010 - 11/2003
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2010 - 11/2003
4Gonadotropin-Releasing Hormone (GnRH)FDA Link
04/2006 - 03/2002
4Phenolsulfonphthalein (Phenol Red)IBA
02/2005 - 08/2002
3Levonorgestrel (Plan B)FDA LinkGeneric
11/2010 - 11/2003
3Matrix MetalloproteinasesIBA
04/2008 - 04/2006
3Caspase 3 (Caspase-3)IBA
12/2007 - 02/2005
3DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
12/2007 - 04/2003
3Epidermal Growth Factor Receptor (EGF Receptor)IBA
12/2007 - 01/2007
2Heparin (Liquaemin)FDA LinkGeneric
01/2012 - 06/2005
2Tissue Inhibitor of Metalloproteinase-2IBA
11/2010 - 04/2008
2EnzymesIBA
05/2010 - 04/2008
2CD147 Antigens (Basigin)IBA
04/2008 - 03/2008
2deoxyuridine triphosphateIBA
12/2007 - 04/2003
2Transforming Growth Factor beta (TGF-beta)IBA
12/2007 - 07/2006
2Proteins (Proteins, Gene)IBA
10/2007 - 04/2006
2Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
10/2006 - 04/2006
2Estradiol (Estrace)FDA LinkGeneric
07/2006 - 08/2002
2Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
02/2006 - 02/2005
2LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA
02/2005 - 03/2002
2DNA (Deoxyribonucleic Acid)IBA
02/2005 - 02/2004
2IGF Type 1 Receptor (IGF 1 Receptor)IBA
01/2005 - 04/2004
2Estriol (Epiestriol)IBA
01/2005 - 01/2005
2Gonadal Steroid Hormones (Sex Hormones)IBA
11/2003 - 08/2002
1Sirolimus (Rapamycin)FDA Link
08/2015
1PolymersIBA
01/2011
1Collagen Type III (Type III Collagen)IBA
11/2010
1Protein Isoforms (Isoforms)IBA
05/2010
1Brain Natriuretic Peptide (Natrecor)FDA Link
11/2008
1Cisplatin (Platino)FDA LinkGeneric
10/2008
1Tissue Inhibitor of Metalloproteinase-1IBA
04/2008
1Matrix Metalloproteinase 14 (MT1-MMP)IBA
04/2008
1Dihydrotachysterol (AT 10)IBA
04/2008
1Transforming Growth Factors (Transforming Growth Factor)IBA
12/2007
1Selective Estrogen Receptor Modulators (SERM)IBA
05/2007
1Raloxifene (Evista)FDA Link
05/2007
1AdiponectinIBA
04/2007
1LatexIBA
02/2007
1TNF-Related Apoptosis-Inducing LigandIBA
02/2007
1Inhibitor of Apoptosis ProteinsIBA
02/2007
1Caspase 8 (Caspase-8)IBA
02/2007
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
09/2006
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
09/2006
1Vascular Endothelial Growth Factor BIBA
09/2006
1Testosterone (Sustanon)FDA Link
07/2006
1Oxytocin (Pitocin)FDA LinkGeneric
01/2006
1Methylergonovine (Methergine)FDA LinkGeneric
01/2006
1Prednisone (Sone)FDA LinkGeneric
11/2005
1Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
08/2005
1heparin-binding EGF-like growth factor (HB-EGF)IBA
06/2005
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
05/2005
1N-acetyltransferase 1IBA
04/2005
1TransferasesIBA
04/2005

Therapy/Procedure

2Stents
08/2015 - 01/2011
2Drug Therapy (Chemotherapy)
10/2008 - 12/2004
2Laparotomy
01/2007 - 06/2004
2Cesarean Section (Caesarean Section)
01/2004 - 05/2003
1Hysterectomy
09/2011
1Oral Administration
09/2011
1Microspheres (Microsphere)
02/2007