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John F Lyons Selected Research

human AKT2 protein

1/2003Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

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John F Lyons Research Topics

Disease

8Neoplasms (Cancer)
01/2015 - 01/2003
2Leukemia
09/2010 - 04/2010
1Melanoma (Melanoma, Malignant)
12/2014
1Prostatic Neoplasms (Prostate Cancer)
07/2012
1Inflammation
01/2011
1Pleurisy (Pleuritis)
01/2011
1Myeloproliferative Disorders (Myeloproliferative Disorder)
07/2010
1Glioblastoma (Glioblastoma Multiforme)
05/2010
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
04/2010
1B-Cell Leukemia (Leukemia, B Cell)
04/2010
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
04/2010
1Colonic Neoplasms (Colon Cancer)
02/2009
1Neoplasm Metastasis (Metastasis)
01/2003
1Ovarian Neoplasms (Ovarian Cancer)
01/2003
1Breast Neoplasms (Breast Cancer)
01/2003

Drug/Important Bio-Agent (IBA)

6Phosphotransferases (Kinase)IBA
12/2014 - 01/2003
34- (2,6- dichlorobenzoylamino)- 1H- pyrazole- 3- carboxylic acid piperidin-4-ylamideIBA
01/2011 - 02/2009
2aurora kinase (aurora A kinase)IBA
01/2015 - 07/2010
21- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA
01/2015 - 07/2010
270-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
07/2012 - 05/2010
2CyclinsIBA
01/2011 - 04/2010
1(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA
12/2014
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
07/2012
1rho-Associated KinasesIBA
07/2012
1OvalbuminIBA
01/2011
1benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
01/2011
1Isoleucine (L-Isoleucine)FDA Link
09/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2010
1imatinib (Gleevec)FDA Link
09/2010
1Threonine (L-Threonine)FDA Link
09/2010
1glycogen synthase kinase 3 betaIBA
05/2010
1AT 7867IBA
05/2010
1Ribosomal Proteins (Ribosomal Protein)IBA
05/2010
1Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
05/2010
1Adenosine Triphosphate (ATP)IBA
05/2010
1Cyclin-Dependent Kinases (cdk Proteins)IBA
04/2010
1RNA Polymerase II (RNA Polymerase B)IBA
04/2010
1Growth Factor ReceptorsIBA
12/2003
1tensins (tensin)IBA
01/2003
1Complementary DNA (cDNA)IBA
01/2003
1IntegrinsIBA
01/2003
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2003
1wortmanninIBA
01/2003
1CollagenIBA
01/2003
1human AKT2 proteinIBA
01/2003

Therapy/Procedure

3Heterologous Transplantation (Xenotransplantation)
07/2012 - 02/2009
1Therapeutics
05/2010