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Reuben Lotan Selected Research

Retinoids

6/2010Mortality in the randomized, controlled lung intergroup trial of isotretinoin.
8/2007Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosis.
5/2006Fenretinide activity in retinoid-resistant oral leukoplakia.
1/2006Expression of retinoid receptors in sebaceous cell carcinoma.
5/2005Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells.
3/20059-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers.
1/2005Effect of retinoic acid and interferon alpha-2a on transitional cell carcinoma of bladder.
10/2004Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling.
9/2004Retinoids in lung cancer: friend, foe, or fellow traveler?
4/2004Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting.
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Reuben Lotan Research Topics

Disease

56Neoplasms (Cancer)
07/2012 - 01/2002
18Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2011 - 01/2002
16Lung Neoplasms (Lung Cancer)
11/2010 - 01/2002
13Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2012 - 01/2002
8Carcinoma (Carcinomatosis)
11/2007 - 05/2003
7Head and Neck Neoplasms (Head and Neck Cancer)
07/2012 - 01/2002
5Adenocarcinoma
03/2011 - 12/2006
4Metaplasia
02/2010 - 02/2003
3Chronic Obstructive Pulmonary Disease (COPD)
12/2012 - 11/2009
3Inflammation
01/2012 - 11/2009
3Esophageal Neoplasms (Esophageal Cancer)
03/2009 - 01/2002
3Oral Leukoplakia
01/2009 - 03/2004
3Prostatic Neoplasms (Prostate Cancer)
03/2006 - 06/2004
3Neoplasm Metastasis (Metastasis)
10/2005 - 01/2002
3Breast Neoplasms (Breast Cancer)
05/2004 - 03/2003
2Leukoplakia
03/2010 - 01/2009
2Urinary Bladder Neoplasms (Bladder Cancer)
01/2008 - 01/2005
2Hyperplasia
12/2006 - 12/2003
2Colorectal Neoplasms (Colorectal Cancer)
12/2004 - 02/2002
2Skin Neoplasms (Skin Cancer)
03/2004 - 01/2002
2Actinic Keratosis
03/2004 - 07/2002
1Starvation
11/2010
1Acne Vulgaris
06/2010
1Cardiovascular Diseases (Cardiovascular Disease)
06/2010
1Pneumonia (Pneumonitis)
04/2010
1Stomach Neoplasms (Stomach Cancer)
03/2010
1Diarrhea
01/2009
1Carcinoid Tumor (Carcinoid)
11/2007
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
11/2007
1Melanoma (Melanoma, Malignant)
08/2007

Drug/Important Bio-Agent (IBA)

13Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2012 - 01/2002
13RetinoidsIBA
06/2010 - 01/2002
9FenretinideIBA
01/2009 - 03/2003
8GTP-Binding Proteins (G-Protein)IBA
12/2012 - 02/2004
8retinoic acid receptor betaIBA
01/2006 - 01/2002
7Biological Markers (Surrogate Marker)IBA
07/2007 - 09/2002
6Messenger RNA (mRNA)IBA
12/2011 - 01/2002
5Proteins (Proteins, Gene)IBA
03/2011 - 01/2002
4celecoxib (Celebrex)FDA Link
02/2010 - 09/2004
4naphthaleneIBA
07/2005 - 04/2002
3Phosphotransferases (Kinase)IBA
11/2010 - 10/2004
3NF-kappa B (NF-kB)IBA
04/2010 - 10/2005
3Galectin 3 (LGALS3)IBA
03/2010 - 05/2004
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2007 - 01/2002
3Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
07/2006 - 01/2002
3retinamideIBA
05/2006 - 09/2002
3DNA (Deoxyribonucleic Acid)IBA
03/2005 - 09/2002
3Vitamin A (Retinol)FDA LinkGeneric
03/2004 - 01/2002
2SmokeIBA
01/2012 - 11/2009
2Isotretinoin (Accutane)FDA LinkGeneric
06/2010 - 01/2002
2Small Interfering RNA (siRNA)IBA
03/2010 - 03/2005
2Eukaryotic Initiation Factor-4EIBA
03/2010 - 03/2005
2CurcuminIBA
03/2010 - 11/2009
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
07/2009 - 01/2004
2vorinostat (suberoylanilide hydroxamic acid)FDA Link
11/2007 - 12/2004
2Histone Deacetylase InhibitorsIBA
11/2007 - 12/2004
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2007 - 09/2005
2Dinoprostone (PGE2)FDA Link
01/2007 - 09/2004
2Cadherins (E-Cadherin)IBA
12/2006 - 06/2004
2AntibodiesIBA
01/2006 - 07/2005
2retinoic acid receptor alphaIBA
01/2006 - 07/2005
2Insulin (Novolin)FDA Link
07/2005 - 10/2004
2Cisplatin (Platino)FDA LinkGeneric
03/2005 - 01/2002
2lonafarnib (SCH 66336)IBA
10/2004 - 08/2003
2methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oateIBA
10/2004 - 01/2002
1Cyclin-Dependent Kinase Inhibitor p16IBA
12/2011
1ParaffinIBA
03/2011
1Formaldehyde (Formol)FDA Link
03/2011
1MicroRNAs (MicroRNA)IBA
12/2010
1alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA
11/2010
1CytokinesIBA
11/2010
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2010
1Repressor ProteinsIBA
03/2010
1Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA
03/2010
1eIF-4BIBA
03/2010
1Carrier Proteins (Binding Protein)IBA
03/2010
1beta-galactosideIBA
03/2010
1Interleukin-1 (Interleukin 1)IBA
01/2010
1Interleukin-1 Receptor-Associated KinasesIBA
01/2010
1tyrosine receptor (receptor, tyrosine)IBA
07/2009
1phorbolIBA
05/2009
1Transcription Factors (Transcription Factor)IBA
05/2009
1Protein Kinase CIBA
05/2009
1Drug CombinationsIBA
03/2009
1Complementary DNA (cDNA)IBA
03/2009
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10/2008
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
10/2008
1Ketoconazole (Nizoral)FDA LinkGeneric
01/2008
1Adenocarcinoma of lungIBA
11/2007
1Hydroxyeicosatetraenoic Acids (HETE)IBA
01/2007
1Leukotriene B4IBA
01/2007
1Arachidonic Acid (Vitamin F)IBA
01/2007
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
01/2007
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2007
1EnzymesIBA
01/2007
170-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
12/2006
1Caspase 8 (Caspase-8)IBA
12/2006
1Actins (F Actin)IBA
07/2006

Therapy/Procedure

21Chemoprevention
07/2012 - 01/2002