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Brendan Lee Selected Research

Nitrogen

7/2015Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder.
11/2012A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria.
5/2012Argininosuccinate lyase deficiency.
6/2011Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase-deficient patients.
10/2008Diagnosis, symptoms, frequency and mortality of 260 patients with urea cycle disorders from a 21-year, multicentre study of acute hyperammonaemic episodes.
12/2007Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes.
1/2006In vivo urea kinetic studies in conscious mice.
10/2005Unmasked adult-onset urea cycle disorders in the critical care setting.
10/2005Nutritional management of urea cycle disorders.
10/2005Considerations in the difficult-to-manage urea cycle disorder patient.
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Brendan Lee Research Topics

Disease

18Inborn Urea Cycle Disorders
07/2015 - 12/2002
12Hyperammonemia
06/2013 - 10/2004
8Ornithine Carbamoyltransferase Deficiency Disease
09/2013 - 10/2003
8Argininosuccinic Aciduria
06/2013 - 10/2004
7Osteogenesis Imperfecta (Lobstein Disease)
06/2014 - 12/2006
5Neoplasms (Cancer)
02/2015 - 09/2005
3Hypertrophy
05/2015 - 12/2005
3Congenital Abnormalities (Deformity)
04/2015 - 02/2007
3Osteoporosis
02/2014 - 12/2006
3Fibrosis (Cirrhosis)
01/2013 - 10/2004
3Hyperargininemia
02/2011 - 10/2004
2Hypertension (High Blood Pressure)
05/2015 - 09/2009
2Contracture
09/2014 - 03/2011
2Inflammation
12/2013 - 05/2003
2Ventricular Heart Septal Defects (Ventricular Septal Defect)
01/2013 - 01/2003
2Hearing Loss (Hearing Impairment)
01/2013 - 11/2007
2Hemophilia A (Haemophilia)
02/2011 - 12/2007
2Citrullinemia
08/2008 - 03/2005
2Nail-Patella Syndrome (Syndrome, Nail-Patella)
05/2007 - 05/2002
2Thrombocytopenia (Thrombopenia)
03/2005 - 02/2002
2Pathologic Constriction (Stenosis)
10/2004 - 01/2003
1Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson)
06/2015
1Genomic Instability
06/2015
1Marfan Syndrome (Marfan's Syndrome)
04/2015
1Necrosis
08/2014
1Leukemia
04/2013
1Lactic Acidosis
03/2013
1Inborn Errors Metabolism (Inborn Errors of Metabolism)
03/2013
1Diaphragmatic Hernia
03/2013
1Pseudohypoparathyroidism
01/2013
1Microphthalmos
01/2013
1Double Outlet Right Ventricle
01/2013
1Pseudopseudohypoparathyroidism
01/2013
1Dysostoses
01/2013
1Infection
12/2012
1Muscular Diseases (Myopathy)
10/2012
1Tracheoesophageal Fistula
07/2012
1Esophageal Atresia
07/2012
1Sleep Apnea Syndromes (Sleep Apnea)
01/2012
1Constipation
01/2012
1Epilepsy (Aura)
01/2012
1Deglutition Disorders (Dysphagia)
01/2012
1Ataxia (Dyssynergia)
01/2012

Drug/Important Bio-Agent (IBA)

14NitrogenIBA
07/2015 - 12/2002
11Urea (Carbamide)FDA LinkGeneric
07/2015 - 12/2002
9AmmoniaIBA
07/2015 - 12/2002
6EnzymesIBA
05/2012 - 02/2002
5Arginine (L-Arginine)FDA Link
11/2012 - 08/2008
5Collagen Type I (Type I Collagen)IBA
03/2011 - 12/2006
4Glycerol (Glycerine)FDA LinkGeneric
05/2014 - 07/2010
4Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA
09/2013 - 09/2004
4SodiumIBA
06/2013 - 07/2010
4Argininosuccinic AcidIBA
06/2013 - 10/2004
4Proteins (Proteins, Gene)IBA
10/2012 - 05/2002
3Glutamine (L-Glutamine)FDA Link
07/2015 - 10/2003
3Congenital diaphragmatic herniaIBA
04/2015 - 02/2007
3Messenger RNA (mRNA)IBA
08/2014 - 09/2005
3Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2012 - 09/2009
3CollagenIBA
01/2010 - 05/2002
3ArginaseIBA
07/2009 - 10/2004
3OrnithineIBA
03/2009 - 07/2006
3CitrullineIBA
03/2009 - 03/2007
2Dietary ProteinsIBA
07/2015 - 02/2011
2DNA (Deoxyribonucleic Acid)IBA
09/2013 - 06/2009
2Hereditary renal agenesisIBA
03/2013 - 01/2013
2AntigensIBA
01/2013 - 02/2007
2phenylacetic acid (phenylacetate)FDA Link
02/2011 - 10/2008
2Branched-Chain Amino AcidsIBA
02/2011 - 04/2004
2Factor VIII (Coagulation Factor VIII)IBA
02/2011 - 12/2007
2Amino AcidsFDA Link
07/2006 - 10/2005
1Craniosynostosis radial aplasia syndromeIBA
06/2015
1DNA HelicasesIBA
06/2015
1AngiotensinsIBA
05/2015
1Losartan (Cozaar)FDA LinkGeneric
05/2015
1Antihypertensive Agents (Antihypertensives)IBA
05/2015
1Angiotensin Receptor AntagonistsIBA
05/2015
1fibrillinIBA
04/2015
1Cadherins (E-Cadherin)IBA
02/2015
1Tacrolimus Binding Proteins (FKBP)IBA
09/2014
1Metalloproteases (Metalloproteinases)IBA
08/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
06/2014
1Carbon MonoxideIBA
02/2014
1Teriparatide (Parathar)FDA Link
02/2014
1E-SelectinIBA
12/2013
1Histone Deacetylases (Histone Deacetylase)IBA
04/2013
1ChromatinIBA
04/2013
1Pyruvate dehydrogenase deficiencyIBA
03/2013
1Lactic AcidFDA LinkGeneric
03/2013
1Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
03/2013
1AcrodysostosisIBA
01/2013
1Cyclic AMP (AMP, Cyclic)IBA
01/2013
1Chromosome 2q37 deletion syndromeIBA
01/2013
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
12/2012
1VACTERL associationIBA
07/2012
1Glucose (Dextrose)FDA LinkGeneric
05/2012
1LipidsIBA
05/2012
1Choline O-Acetyltransferase (Choline Acetyltransferase)IBA
01/2012
1Vesicular Acetylcholine Transport Proteins (Vesicular Acetylcholine Transporter)IBA
01/2012

Therapy/Procedure

3Liver Transplantation
05/2012 - 10/2004
1Hepatectomy
03/2013