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Pedro A Lazo Selected Research

Vaccinia

1/2015The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.
1/2015VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.
4/2014Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response.
4/2013Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.
12/2012Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
7/2012Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
12/2011Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications.
8/2011Roles of VRK1 as a new player in the control of biological processes required for cell division.
1/2011Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
10/2010VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.
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Pedro A Lazo Research Topics

Disease

25Vaccinia
01/2015 - 03/2002
9Neoplasms (Cancer)
04/2014 - 02/2003
5Carcinoma (Carcinomatosis)
04/2014 - 02/2002
3Breast Neoplasms (Breast Cancer)
04/2014 - 10/2010
3Infection
09/2011 - 08/2006
2Anoxia (Hypoxia)
10/2008 - 10/2007
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
01/2015
1Colorectal Neoplasms (Colorectal Cancer)
12/2013
1Neurodegenerative Diseases (Neurodegenerative Disease)
04/2013
1Ataxia Telangiectasia (Louis Bar Syndrome)
07/2012
1Genomic Instability
01/2010
1Adenoma (Adenomas)
01/2010
1Lung Neoplasms (Lung Cancer)
04/2009
1RNA Virus Infections
10/2008
1B-Cell Lymphoma (Lymphoma, B Cell)
10/2008
1T-Cell Lymphoma (Lymphoma, T Cell)
02/2003

Drug/Important Bio-Agent (IBA)

25Phosphotransferases (Kinase)IBA
01/2015 - 03/2002
11Proteins (Proteins, Gene)IBA
04/2013 - 04/2003
5DNA (Deoxyribonucleic Acid)IBA
04/2014 - 10/2008
3Viral ProteinsIBA
09/2011 - 08/2006
3Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2008 - 08/2006
2Nonsense Codon (Nonsense Mutation)IBA
01/2015 - 04/2009
2Mitogen-Activated Protein KinasesIBA
04/2013 - 01/2011
2Small Interfering RNA (siRNA)IBA
07/2012 - 10/2007
2ChromatinIBA
08/2011 - 11/2008
2Protein Kinases (Protein Kinase)IBA
10/2010 - 10/2007
2Viral DNAIBA
01/2010 - 10/2008
2Complementary DNA (cDNA)IBA
04/2009 - 02/2002
2Serine (L-Serine)FDA Link
04/2009 - 10/2008
2Transcription Factors (Transcription Factor)IBA
11/2008 - 12/2007
2tebufenozide (Mimic)IBA
02/2003 - 02/2002
1Amyloid (Amyloid Fibrils)IBA
01/2015
1Doxorubicin (Adriamycin)FDA LinkGeneric
04/2014
1Estrogens (Estrogen)FDA Link
04/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2013
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2012
1IonomycinIBA
12/2012
1phorbolIBA
12/2012
1Nuclear Proteins (Protein, Nuclear)IBA
12/2011
1Cyclin D1IBA
08/2011
1Histones (Histone)IBA
08/2011
1Epidermal Growth Factor (EGF)IBA
10/2010
1Tumor Viral Antigens (Large T Antigen)IBA
01/2010
1Messenger RNA (mRNA)IBA
04/2009
1GTP Phosphohydrolases (GTPases)IBA
11/2008
1Carbon MonoxideIBA
10/2008
1EnzymesIBA
10/2008
1Interferon Type IIBA
10/2008
1Tumor Suppressor Protein p53IBA
10/2008
1Casein Kinase I (Casein Kinase 1)IBA
10/2008
1JNK Mitogen-Activated Protein KinasesIBA
10/2007
1Protein Isoforms (Isoforms)IBA
06/2006
1CD53 antigenIBA
02/2003
1AntigensIBA
02/2003

Therapy/Procedure

1Ligation
02/2003