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Alan H Lazarus Selected Research

Intravenous Immunoglobulins (IVIG)

6/2015CD44 antibody-mediated amelioration of murine immune thrombocytopenia (ITP): mouse background determines the effect of FcγRIIb genetic disruption.
6/2014Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.
3/2014Antibody specific for the glycophorin A complex mediates intravenous immune globulin-resistant anemia in a murine model.
1/2013Amelioration of murine passive immune thrombocytopenia by IVIg and a therapeutic monoclonal CD44 antibody does not require the Myd88 signaling pathway.
1/2012Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production.
12/2011The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia.
1/2011Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP?
5/2010Adoptive-transfer effects of intravenous immunoglobulin in autoimmunity.
4/2008The mechanisms of action of intravenous immunoglobulin and polyclonal anti-d immunoglobulin in the amelioration of immune thrombocytopenic purpura: what do we really know?
1/2007A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
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Alan H Lazarus Research Topics

Disease

24Thrombocytopenia (Thrombopenia)
07/2015 - 05/2003
8Autoimmune Diseases (Autoimmune Disease)
06/2015 - 12/2003
6Thrombocytopenic Purpura (Thrombopenic Purpura)
04/2009 - 01/2005
5Hemorrhage
07/2015 - 04/2006
3Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
12/2003 - 05/2003
2Inflammation
06/2014 - 01/2013
2Arthritis (Polyarthritis)
06/2014 - 01/2013
2Anemia
03/2014 - 05/2003
2Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
01/2013 - 04/2009
2Purpura
07/2003 - 05/2003
1Body Weight (Weight, Body)
06/2014
1Hemolytic Anemia
03/2014
1Hemolysis
03/2014
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2013
1Acute Lung Injury
01/2012
1Shock
01/2012
1Dyspnea (Shortness of Breath)
01/2012
1Tetanus
09/2010
1Neonatal Alloimmune Thrombocytopenia
04/2006

Drug/Important Bio-Agent (IBA)

23Inosine Triphosphate (ITP)IBA
07/2015 - 05/2003
18Intravenous Immunoglobulins (IVIG)FDA Link
06/2015 - 05/2003
11AntibodiesIBA
06/2015 - 05/2003
9Immunoglobulins (Immunoglobulin)IBA
01/2013 - 05/2003
6AntigensIBA
01/2013 - 05/2003
5Immunoglobulin G (IgG)IBA
06/2014 - 05/2003
4Monoclonal AntibodiesIBA
06/2015 - 05/2003
3RHO(D) antibody (anti-D)IBA
06/2015 - 06/2003
2Fc Receptors (Fc Receptor)IBA
07/2010 - 02/2005
1AutoantibodiesIBA
07/2015
1Membrane Proteins (Integral Membrane Proteins)IBA
07/2015
1DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN)IBA
06/2014
1CollagenIBA
06/2014
1Glycophorin (Glycophorin C)IBA
03/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2012
1neonatal Fc receptorIBA
12/2011
1Muramidase (Lysozyme)IBA
09/2010
1Diphtheria-Tetanus VaccineIBA
09/2010
1gamma-Globulins (gamma-Globulin)IBA
02/2010
1Rho(D) Immune Globulin (RhoGAM)IBA
04/2008
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2007
1Antigen-Antibody Complex (Immune Complex)IBA
10/2006
1IgG Receptors (Fc gamma RI)IBA
06/2006
1Caspase 3 (Caspase-3)IBA
04/2006
1Glycoproteins (Glycoprotein)IBA
04/2006
1Platelet Membrane Glycoprotein IIbIBA
04/2006
1Integrin beta3 (GPIIIa)IBA
04/2006
1Toll-Like Receptors (Toll-Like Receptor)IBA
01/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2006
1Fc gamma receptor IIBIBA
02/2005
1tebufenozide (Mimic)IBA
01/2005
1Heparin (Liquaemin)FDA LinkGeneric
05/2003
1Immunoglobulin M (IgM)IBA
05/2003

Therapy/Procedure

2Therapeutics
01/2013 - 01/2013
1Platelet Transfusion (Blood Platelet Transfusions)
01/2014