Paul A Lapchak Selected Research

Stroke (Strokes)

1/2019	CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.
1/2018	Intravenous xenogeneic human cardiosphere-derived cell extracellular vesicles (exosomes) improves behavioral function in small-clot embolized rabbits.
1/2018	Data Standardization and Quality Management.
4/2017	Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones.
1/2016	Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial.
1/2016	A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke.
10/2015	Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection.
4/2015	A blinded, randomized study of L-arginine in small clot embolized rabbits.
8/2014	Effect of the Pleiotropic Drug CNB-001 on Tissue Plasminogen Activator (tPA) Protease Activity in vitro: Support for Combination Therapy to Treat Acute Ischemic Stroke.
4/2013	Synergistic Effect of AJW200, a von Willebrand Factor Neutralizing Antibody with Low Dose (0.9 mg/mg) Thrombolytic Therapy Following Embolic Stroke in Rabbits.

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Paul A Lapchak Research Topics

Disease

42	Stroke (Strokes) 01/2019 - 01/2002
39	Ischemic Stroke 04/2017 - 01/2002
24	Embolic Stroke 01/2016 - 05/2002
14	Ischemia 12/2019 - 01/2002
13	Thrombosis (Thrombus) 04/2013 - 01/2002
12	Cerebral Hemorrhage 01/2018 - 01/2002
12	Hemorrhage 01/2011 - 01/2002
10	Infarction (Infarctions) 01/2019 - 01/2002
5	Embolism (Embolus) 08/2010 - 01/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 01/2012
4	Brain Ischemia (Cerebral Ischemia) 06/2011 - 10/2007
3	Spinal Cord Ischemia 12/2019 - 01/2003
3	Alzheimer Disease (Alzheimer's Disease) 07/2015 - 05/2006
3	Hepatocellular Carcinoma (Hepatoma) 08/2013 - 03/2011
3	Hemorrhagic Stroke 06/2013 - 09/2007
2	Paraplegia (Spastic Paraplegia) 12/2019 - 01/2003
2	Inflammation (Inflammations) 04/2013 - 03/2007
1	Wounds and Injuries (Trauma) 12/2019
1	Abdominal Aortic Aneurysm 12/2019
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2019
1	Hypotension (Low Blood Pressure) 10/2015
1	Apnea 10/2015
1	Hypoxia (Hypoxemia) 07/2015
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2015
1	Type 2 Diabetes Mellitus (MODY) 09/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 09/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2014
1	Neoplasms (Cancer) 09/2014
1	Insulin Resistance 05/2014
1	Glucose Intolerance 05/2014
1	Obesity 05/2014
1	Body Weight (Weight, Body) 05/2014

Drug/Important Bio-Agent (IBA)

31	Tissue Plasminogen Activator (Alteplase)FDA Link 04/2017 - 01/2002
16	Pharmaceutical PreparationsIBA 01/2018 - 11/2002
11	Neuroprotective AgentsIBA 01/2017 - 05/2002
7	CNB 001IBA 12/2019 - 01/2011
7	disufenton sodium (NXY 059)IBA 03/2011 - 05/2002
6	CurcuminIBA 12/2019 - 01/2011
5	SuspensionsIBA 07/2010 - 05/2002
4	Simvastatin (Zocor)FDA LinkGeneric 07/2015 - 12/2009
3	Memantine (Namenda)FDA Link 12/2019 - 05/2006
3	Proteins (Proteins, Gene)FDA Link 07/2015 - 04/2013
3	EdaravoneIBA 01/2013 - 01/2009
3	Metalloproteases (Metalloproteinases)IBA 01/2011 - 03/2007
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2010 - 09/2007
3	Tenecteplase FDA Link 10/2009 - 01/2004
3	AntioxidantsIBA 01/2009 - 08/2003
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 09/2007 - 02/2006
3	Free RadicalsIBA 01/2003 - 01/2002
3	SM 20302IBA 01/2003 - 01/2002
2	Phenol (Carbolic Acid)FDA Link 12/2019 - 05/2014
2	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 12/2019 - 01/2019
2	Adenosine Triphosphate (ATP)IBA 01/2016 - 01/2010
2	Insulin (Novolin)FDA Link 09/2014 - 05/2014
2	Tyrosine (L-Tyrosine)FDA Link 09/2014 - 05/2014
2	DiarylheptanoidsIBA 05/2014 - 01/2011
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2013 - 01/2002
2	FlavonoidsIBA 01/2012 - 10/2007
2	Erythropoietin FDA Link 10/2010 - 09/2007
2	Drug CombinationsIBA 01/2009 - 06/2002
2	Platelet Membrane Glycoprotein IIbIBA 01/2003 - 01/2002
2	FibrinIBA 11/2002 - 01/2002
2	OxidesIBA 06/2002 - 05/2002
2	Benzene (Benzole)IBA 06/2002 - 05/2002
2	Glycoproteins (Glycoprotein)IBA 01/2002 - 01/2002
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 12/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019
1	triphosphoric acid (triphosphate)IBA 01/2016
1	Adenosine (Adenocard)FDA LinkGeneric 01/2016
1	Anesthetics (Anesthetic Agents)IBA 10/2015
1	Propofol (Diprivan)FDA LinkGeneric 10/2015
1	Isoflurane FDA LinkGeneric 10/2015
1	EnzymesIBA 07/2015
1	Amyloid (Amyloid Fibrils)IBA 07/2015
1	Arginine (L-Arginine)FDA Link 04/2015
1	Nitric Oxide Synthase (NO Synthase)IBA 04/2015
1	Saline SolutionIBA 04/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2015
1	Peptide Hydrolases (Proteases)FDA Link 08/2014
1	Interleukin-6 (Interleukin 6)IBA 05/2014
1	Hypoglycemic Agents (Hypoglycemics)IBA 05/2014
1	Glucose (Dextrose)FDA LinkGeneric 05/2014
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/2014
1	PhosphoproteinsIBA 05/2014
1	Phosphotransferases (Kinase)IBA 05/2014
1	Triglycerides (Triacylglycerol)IBA 05/2014
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2014
1	J147IBA 08/2013
1	von Willebrand FactorIBA 04/2013
1	Neutralizing AntibodiesIBA 04/2013
1	Free Radical ScavengersIBA 01/2013

Therapy/Procedure

26	Therapeutics 01/2019 - 01/2002
9	Catheters 06/2011 - 01/2002
6	Thrombolytic Therapy 04/2017 - 01/2002
6	Laser Therapy (Surgery, Laser) 01/2016 - 08/2004
4	Lasers (Laser) 01/2016 - 08/2004
2	Endovascular Procedures 01/2019 - 04/2017
2	Treatment Delay 04/2013 - 01/2011
1	Operative Surgical Procedures 12/2019
1	Endovascular Aneurysm Repair 12/2019