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Razelle Kurzrock Selected Research

bevacizumab

8/2015Dose-finding study of hepatic arterial infusion of irinotecan-based treatment in patients with advanced cancers metastatic to the liver.
4/2015VEGF-A Expression Correlates with TP53 Mutations in Non-Small Cell Lung Cancer: Implications for Antiangiogenesis Therapy.
2/2015A phase I trial of combination trastuzumab, lapatinib, and bevacizumab in patients with advanced cancer.
2/2015Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors.
11/2014A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours.
11/2014Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab.
8/2014Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms.
7/2014Dual inhibition of the vascular endothelial growth factor pathway: a phase 1 trial evaluating bevacizumab and AZD2171 (cediranib) in patients with advanced solid tumors.
4/2014Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus.
4/2014Pediatric patients with refractory central nervous system tumors: experiences of a clinical trial combining bevacizumab and temsirolimus.
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Razelle Kurzrock Research Topics

Disease

156Neoplasms (Cancer)
12/2015 - 07/2002
24Neoplasm Metastasis (Metastasis)
08/2015 - 08/2004
14Fatigue
08/2015 - 02/2004
13Carcinoma (Carcinomatosis)
09/2015 - 11/2004
13Thrombocytopenia (Thrombopenia)
07/2015 - 02/2004
13Pancreatic Neoplasms (Pancreatic Cancer)
03/2015 - 09/2006
11Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2015 - 10/2010
11Breast Neoplasms (Breast Cancer)
03/2015 - 06/2009
10Colorectal Neoplasms (Colorectal Cancer)
01/2015 - 08/2004
10Myelodysplastic Syndromes (Myelodysplastic Syndrome)
10/2008 - 07/2002
9Melanoma (Melanoma, Malignant)
12/2015 - 08/2005
9Hematologic Neoplasms (Hematological Malignancy)
12/2014 - 01/2002
9Ovarian Neoplasms (Ovarian Cancer)
06/2014 - 04/2011
8Giant Lymph Node Hyperplasia (Castleman's Disease)
01/2016 - 09/2007
8Exanthema (Rash)
08/2015 - 07/2006
7Infection
10/2015 - 01/2002
7Neutropenia
08/2015 - 11/2010
7Hypertension (High Blood Pressure)
07/2015 - 01/2010
7Mucositis
04/2014 - 07/2006
6Diarrhea
08/2015 - 01/2008
6BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2014 - 10/2002
6Fever (Fevers)
07/2013 - 10/2003
6Lung Neoplasms (Lung Cancer)
01/2013 - 12/2007
6Ewing's Sarcoma (Sarcoma, Ewing)
01/2013 - 04/2010
6Leukemia
01/2008 - 07/2002
5Prostatic Neoplasms (Prostate Cancer)
11/2015 - 10/2010
5Nausea
09/2015 - 10/2002
5Renal Cell Carcinoma (Grawitz Tumor)
02/2015 - 02/2002
5Disease Progression
04/2014 - 07/2008
5Lymphoma (Lymphomas)
09/2011 - 02/2004
4Lymphoproliferative Disorders (Lymphoproliferative Disorder)
10/2015 - 08/2003
4Weight Loss (Weight Reduction)
09/2015 - 12/2004
4Anoxia (Hypoxia)
11/2014 - 06/2009
4Erdheim-Chester Disease
07/2014 - 11/2005
4Pain (Aches)
10/2011 - 12/2007
4B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
02/2009 - 08/2002
4Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
07/2006 - 07/2003
3Hypercholesterolemia
10/2015 - 04/2014
3Hypertriglyceridemia
10/2015 - 02/2004
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2015 - 06/2008
3Sarcoma (Soft Tissue Sarcoma)
01/2015 - 05/2007
3Hemorrhage
07/2014 - 02/2005

Drug/Important Bio-Agent (IBA)

27bevacizumabFDA Link
08/2015 - 01/2010
20Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2015 - 12/2004
15Phosphotransferases (Kinase)IBA
01/2015 - 05/2007
13Interleukin-6 (Interleukin 6)IBA
10/2015 - 02/2002
13CurcuminIBA
02/2013 - 11/2004
13Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2011 - 08/2002
11DNA (Deoxyribonucleic Acid)IBA
09/2015 - 06/2009
11oxaliplatin (Eloxatin)FDA LinkGeneric
08/2015 - 04/2007
11temsirolimusFDA Link
07/2015 - 04/2011
11Epidermal Growth Factor Receptor (EGF Receptor)IBA
03/2015 - 07/2008
9Interleukin-8 (Interleukin 8)IBA
08/2013 - 11/2004
9tipifarnib (R115777)IBA
04/2011 - 07/2002
8AntibodiesIBA
04/2015 - 12/2006
8sorafenib (BAY 43-9006)FDA Link
02/2015 - 05/2008
8Farnesyltranstransferase (Farnesyltransferase)IBA
12/2010 - 07/2002
7tranilast (N 5')IBA
11/2015 - 09/2010
7Insulin (Novolin)FDA Link
07/2015 - 01/2011
7imatinib (Gleevec)FDA Link
07/2014 - 08/2006
7Fluorouracil (Carac)FDA LinkGeneric
02/2013 - 08/2004
6monoclonal antibody CNTO 328IBA
01/2016 - 08/2010
6Biological Markers (Surrogate Marker)IBA
11/2015 - 09/2008
6CytokinesIBA
09/2015 - 12/2004
6Sirolimus (Rapamycin)FDA Link
07/2015 - 08/2010
6Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2015 - 01/2005
6Paclitaxel (Taxol)FDA LinkGeneric
03/2015 - 12/2006
6PlatinumIBA
01/2015 - 04/2011
6NF-kappa B (NF-kB)IBA
12/2009 - 11/2004
5InterleukinsIBA
10/2015 - 02/2002
5cetuximab (Erbitux)FDA Link
08/2015 - 02/2011
5Aspartate Aminotransferases (Aspartate Transaminase)IBA
07/2015 - 03/2009
5Lipase (Acid Lipase)FDA Link
01/2015 - 12/2010
5Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
08/2014 - 05/2008
5Interferon-alpha (Interferon Alfa)FDA Link
01/2011 - 01/2002
4Protein Kinases (Protein Kinase)IBA
12/2015 - 08/2005
4ParaffinIBA
09/2015 - 05/2006
4everolimusFDA Link
06/2015 - 11/2013
4Carboplatin (JM8)FDA LinkGeneric
06/2015 - 06/2012
4lapatinib (GW572016)FDA Link
02/2015 - 11/2013
4erlotinib (CP 358,774)FDA Link
01/2014 - 07/2008
4Heat-Shock Proteins (Heat-Shock Protein)IBA
09/2013 - 11/2011
4Leucovorin (Folinic Acid)FDA Link
02/2013 - 09/2010
4Doxorubicin (Adriamycin)FDA LinkGeneric
10/2012 - 11/2010
3aurora kinase (aurora A kinase)IBA
12/2015 - 12/2014
3irinotecan (Camptosar)FDA LinkGeneric
08/2015 - 12/2012
3Staphylococcal Protein A (A, Protein)IBA
06/2015 - 09/2003
3Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
04/2015 - 10/2008
3trastuzumab (Herceptin)FDA Link
02/2015 - 03/2014
3medullary Thyroid cancerIBA
02/2015 - 11/2009
3Estrogens (Estrogen)FDA Link
01/2015 - 01/2011
3Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
07/2014 - 06/2010
3Interleukin-1 (Interleukin 1)IBA
07/2014 - 12/2004
3Adrenal Cortex Hormones (Corticosteroids)IBA
07/2014 - 01/2002
3Histone Deacetylase InhibitorsIBA
03/2014 - 06/2009

Therapy/Procedure

21Drug Therapy (Chemotherapy)
09/2015 - 01/2002
10Heterologous Transplantation (Xenotransplantation)
04/2014 - 10/2002
8Therapeutics
11/2015 - 05/2003
4Individualized Medicine
09/2014 - 09/2011
3Molecular Targeted Therapy
09/2015 - 09/2011