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Isao Kubota Selected Research

Diacylglycerol Kinase

1/2014Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion.
1/2011Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.
1/2009Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
2/2008Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
1/2008Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
9/2007Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
2/2007Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
2/2007Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
1/2006Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice.
3/2005Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy.

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Isao Kubota Research Topics

Disease

38Heart Failure
01/2015 - 05/2003
11Cardiomegaly (Heart Hypertrophy)
01/2014 - 01/2003
9Hypertension (High Blood Pressure)
01/2015 - 04/2002
9Chronic Obstructive Pulmonary Disease (COPD)
01/2014 - 11/2003
8Atrial Fibrillation
10/2015 - 01/2003
8Myocardial Infarction
01/2015 - 07/2003
8Inflammation
05/2014 - 11/2005
6Body Weight (Weight, Body)
02/2014 - 11/2005
6Albuminuria
12/2013 - 03/2009
5Obesity
01/2015 - 01/2007
5Coronary Artery Disease (Coronary Atherosclerosis)
09/2014 - 11/2006
5Fibrosis (Cirrhosis)
09/2013 - 12/2003
4Neoplasms (Cancer)
04/2015 - 10/2003
4Renal Insufficiency (Renal Failure)
01/2015 - 10/2005
4Emphysema
01/2014 - 09/2006
4Insulin Resistance
01/2014 - 04/2007
4Hypertrophy
09/2013 - 04/2004
4Kidney Diseases (Kidney Disease)
08/2013 - 07/2009
4Stroke (Strokes)
08/2012 - 08/2006
4Edema
01/2010 - 09/2002
3Hemorrhage
08/2015 - 06/2009
3Cardiovascular Diseases (Cardiovascular Disease)
01/2015 - 01/2011
3Ischemia
01/2014 - 07/2003
3Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2013 - 04/2002
3Tachycardia (Tachyarrhythmias)
01/2011 - 07/2006
3Spasm (Spasms)
01/2011 - 07/2003
3Chronic Kidney Failure (Chronic Renal Failure)
06/2009 - 09/2002
3Ventricular Remodeling
02/2007 - 11/2002
2Peripheral Arterial Disease
12/2015 - 10/2015
2Cardiomyopathies (Cardiomyopathy)
05/2015 - 11/2003
2Hypotension (Low Blood Pressure)
01/2015 - 12/2013
2Anemia
05/2014 - 04/2014
2Pulmonary Emphysema
01/2014 - 05/2008
2Lung Diseases (Lung Disease)
01/2013 - 04/2012
2Proteinuria
01/2013 - 03/2007
2Death (Near-Death Experience)
07/2012 - 04/2009
2Glucose Intolerance
06/2011 - 08/2009
2Neoplasm Metastasis (Metastasis)
01/2010 - 10/2003
2Pathologic Constriction (Stenosis)
01/2010 - 06/2009
2Infection
05/2008 - 10/2006
2Vascular System Injuries
09/2007 - 07/2006

Drug/Important Bio-Agent (IBA)

11Brain Natriuretic Peptide (Natrecor)FDA Link
01/2015 - 08/2005
10Diacylglycerol KinaseIBA
01/2014 - 03/2005
8Carrier Proteins (Binding Protein)IBA
12/2015 - 02/2005
8CreatinineIBA
10/2015 - 10/2005
7Protein Kinase CIBA
01/2014 - 03/2005
5AdiponectinIBA
01/2015 - 08/2009
5Angiotensin IIIBA
09/2013 - 04/2004
5Uric Acid (Urate)IBA
08/2013 - 05/2006
5Collagen Type I (Type I Collagen)IBA
06/2007 - 12/2003
4PTX3 proteinIBA
12/2015 - 01/2008
4SodiumIBA
01/2015 - 04/2009
4Biological Markers (Surrogate Marker)IBA
08/2012 - 04/2004
4CollagenIBA
02/2007 - 04/2002
3Troponin T (T, Troponin)IBA
12/2015 - 03/2007
3Cystatin CIBA
10/2015 - 10/2005
3HMGB1 Protein (HMG1)IBA
05/2015 - 10/2008
3human NPPA protein (carperitide)IBA
01/2015 - 12/2013
3Hemoglobins (Hemoglobin)IBA
01/2015 - 04/2009
3tolvaptanFDA Link
01/2015 - 12/2013
3DNA (Deoxyribonucleic Acid)IBA
09/2013 - 10/2005
3SmokeIBA
01/2013 - 03/2007
3Interleukin-6 (Interleukin 6)IBA
12/2011 - 05/2008
3Glucose (Dextrose)FDA LinkGeneric
06/2011 - 01/2007
3Insulin (Novolin)FDA Link
06/2011 - 04/2009
3GTP-Binding Proteins (G-Protein)IBA
01/2009 - 09/2007
3Heat-Shock Proteins (Heat-Shock Protein)IBA
09/2008 - 12/2003
2Warfarin (Coumadin)FDA LinkGeneric
08/2015 - 01/2013
2ReninIBA
04/2015 - 04/2012
2Pregnancy-Associated Plasma Protein-A (PAPP-A)IBA
01/2015 - 10/2011
2LipidsIBA
01/2015 - 04/2012
2LDL CholesterolIBA
07/2014 - 08/2009
2Lipoproteins (Lipoprotein)IBA
07/2014 - 11/2006
2AdipokinesIBA
05/2014 - 01/2014
2midkineIBA
01/2014 - 04/2010
2Pancreatic Elastase (Elastase)IBA
01/2014 - 05/2008
2Contrast MediaIBA
08/2013 - 08/2013
2Carbon MonoxideIBA
04/2013 - 11/2003
2AntibodiesIBA
01/2013 - 01/2013
2CytokinesIBA
01/2013 - 01/2009
2Reactive Oxygen Species (Oxygen Radicals)IBA
07/2011 - 07/2006
2NeopterinIBA
11/2010 - 04/2005
2Adenocarcinoma of lungIBA
01/2010 - 10/2003
2C-Reactive ProteinIBA
04/2009 - 03/2005
2HDL CholesterolIBA
04/2009 - 08/2008
2Phospholipases (Phospholipase)IBA
01/2009 - 11/2005
2Endothelin-1 (Endothelin 1)IBA
03/2008 - 05/2003
2pentosidineIBA
03/2008 - 04/2007
2Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)IBA
02/2008 - 01/2006
2fibrinmonomerIBA
10/2007 - 08/2006
2CCAAT-Enhancer-Binding Protein-betaIBA
03/2007 - 10/2006
2Collagen Type III (Type III Collagen)IBA
02/2007 - 02/2007
2Phenylephrine (Neo-Synephrine)FDA LinkGeneric
02/2007 - 01/2006
2OxygenIBA
02/2006 - 11/2003

Therapy/Procedure

3Renal Dialysis (Hemodialysis)
06/2009 - 09/2002
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2015 - 09/2006
2Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
07/2012 - 01/2011
2Stents
01/2010 - 06/2009
2Angioplasty (Angioplasty, Transluminal)
06/2009 - 07/2006
2Intravenous Infusions
06/2008 - 01/2003