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Zaklina Kovacevic Selected Research

Cyclin-Dependent Kinase Inhibitor p21

1/2013The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.
10/2011Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer.

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Zaklina Kovacevic Research Topics

Disease

18Neoplasms (Cancer)
11/2015 - 12/2006
17Neoplasm Metastasis (Metastasis)
11/2015 - 12/2006
5Pancreatic Neoplasms (Pancreatic Cancer)
01/2015 - 10/2008
2Prostatic Neoplasms (Prostate Cancer)
01/2015 - 01/2009
2Anoxia (Hypoxia)
01/2013 - 05/2012
1Colonic Neoplasms (Colon Cancer)
07/2014
1Peripheral Primitive Neuroectodermal Tumors (Peripheral Neuroectodermal Tumor)
01/2013
1Iron Overload
01/2013
1Carcinoma (Carcinomatosis)
01/2013
1Inborn Genetic Diseases (Disease, Hereditary)
12/2006

Drug/Important Bio-Agent (IBA)

18IronIBA
10/2015 - 12/2006
13Chelating AgentsIBA
10/2015 - 12/2006
6di- 2- pyridylketone- 4,4- dimethyl- 3- thiosemicarbazoneIBA
10/2015 - 01/2013
4LigandsIBA
08/2015 - 01/2011
3Phosphotransferases (Kinase)IBA
11/2015 - 09/2013
3Cyclin D1IBA
10/2015 - 10/2011
3ThiosemicarbazonesIBA
10/2015 - 09/2012
3CopperIBA
10/2015 - 01/2013
3Deferoxamine (Desferal)FDA LinkGeneric
01/2015 - 09/2012
2Proteins (Proteins, Gene)IBA
11/2015 - 01/2013
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
10/2015 - 04/2014
2DNA (Deoxyribonucleic Acid)IBA
10/2015 - 04/2014
2Cyclin-Dependent Kinase Inhibitor p21IBA
01/2013 - 10/2011
2Transforming Growth Factor beta (TGF-beta)IBA
01/2013 - 01/2009
1IntegrinsIBA
11/2015
1tyrosine receptor (receptor, tyrosine)IBA
11/2015
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2015
1CyclinsIBA
10/2015
1Messenger RNA (mRNA)IBA
10/2015
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
10/2015
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2015
1InterleukinsIBA
01/2015
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2015
1Transforming Growth Factors (Transforming Growth Factor)IBA
07/2014
1Cadherins (E-Cadherin)IBA
07/2014
13-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
04/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2014
1Actins (F Actin)IBA
09/2013
1Protein Kinases (Protein Kinase)IBA
09/2013
1Sirolimus (Rapamycin)FDA Link
09/2013
1Antineoplastic Agents (Antineoplastics)IBA
03/2013
1TunicamycinIBA
01/2013
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2013
1deferasiroxFDA Link
01/2013
1NF-kappa B (NF-kB)IBA
01/2013
1Caspase 3 (Caspase-3)IBA
01/2013
1Cyclin-Dependent Kinase Inhibitor p27IBA
01/2013
1quinolineIBA
09/2012
1Fluorouracil (Carac)FDA LinkGeneric
10/2011
1gemcitabineFDA Link
10/2011
1SiderophoresIBA
01/2011
1silybin (silibinin)IBA
01/2011
1CurcuminIBA
01/2011
1Cathepsin CIBA
10/2008
1metsulfuron methyl (Ally)IBA
12/2006
1AndrogensIBA
12/2006
1LOM type hereditary motor and sensory NeuropathyIBA
12/2006

Therapy/Procedure

3Therapeutics
10/2015 - 01/2011
3Heterologous Transplantation (Xenotransplantation)
01/2015 - 10/2011
1Drug Therapy (Chemotherapy)
11/2013