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Thomas R Kosten Selected Research

Cocaine (Cocaine HCl)

8/2013Can you vaccinate against substance abuse?
4/2013DBH gene as predictor of response in a cocaine vaccine clinical trial.
3/2013Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.
3/2013Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.
1/2012The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial.
1/2011Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients.
9/2010Anti-cocaine vaccine development.
10/2009Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.
4/2009Vaccines for cocaine abuse.
1/2009Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.
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Thomas R Kosten Research Topics

Disease

51Schizophrenia (Dementia Praecox)
01/2016 - 01/2002
38Cocaine-Related Disorders (Cocaine Addiction)
09/2014 - 04/2002
19Substance-Related Disorders (Drug Abuse)
11/2014 - 01/2002
9Movement Disorders (Movement Disorder)
10/2013 - 05/2010
7Substance Withdrawal Syndrome (Withdrawal Symptoms)
05/2009 - 01/2002
6Tobacco Use Disorder (Nicotine Dependence)
10/2012 - 04/2002
4Opioid-Related Disorders (Opiate Addiction)
10/2013 - 01/2004
4Body Weight (Weight, Body)
01/2012 - 06/2007
4Alcoholism (Alcohol Abuse)
02/2011 - 01/2007
3Paranoid Disorders (Paranoia)
04/2013 - 05/2005
3Weight Gain
08/2008 - 06/2007
2Gambling (Pathological Gambling)
11/2015 - 10/2004
2Type 2 Diabetes Mellitus (MODY)
04/2013 - 07/2012
2Diabetes Mellitus
08/2011 - 04/2011
2Pain (Aches)
01/2007 - 11/2003
1Parkinson Disease (Parkinson's Disease)
11/2015
1Impulse Control Disorders (Kleptomania)
11/2015
1Depressive Disorder (Melancholia)
08/2015
1Post-Traumatic Stress Disorders (PTSD)
08/2014
1Brain Injuries (Brain Injury)
06/2013
1Muscle Weakness
03/2013
1Hyperprolactinemia
07/2009

Drug/Important Bio-Agent (IBA)

27Cocaine (Cocaine HCl)IBA
08/2013 - 01/2002
16Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2016 - 12/2007
14Dopamine (Intropin)FDA LinkGeneric
08/2014 - 01/2002
12Antipsychotic Agents (Antipsychotics)IBA
01/2014 - 06/2007
11Methadone (Dolophine)FDA LinkGeneric
01/2011 - 01/2002
10Disulfiram (Antabuse)FDA Link
03/2014 - 04/2002
7Superoxide DismutaseIBA
05/2014 - 05/2007
7VaccinesIBA
08/2013 - 10/2002
6Buprenorphine (Subutex)FDA LinkGeneric
03/2014 - 01/2002
6Clozapine (Clozaril)FDA LinkGeneric
01/2014 - 06/2007
5NicotineFDA Link
08/2013 - 04/2002
4Naltrexone (ReVia)FDA LinkGeneric
10/2013 - 07/2003
4Carbon MonoxideIBA
04/2013 - 01/2012
4Risperidone (Risperdal Consta)FDA LinkGeneric
09/2012 - 12/2007
4Heroin (Diamorphine)IBA
01/2009 - 01/2002
3CytokinesIBA
01/2016 - 07/2008
3Interleukin-2 (IL2)IBA
01/2016 - 05/2009
3Interleukin-6 (Interleukin 6)IBA
01/2016 - 07/2008
3Norepinephrine (Noradrenaline)FDA LinkGeneric
08/2014 - 02/2013
3Methamphetamine (Desoxyn)FDA LinkGeneric
08/2013 - 10/2008
3Dopamine beta-HydroxylaseIBA
07/2013 - 11/2003
2InterleukinsIBA
01/2016 - 12/2008
2Interleukin-8 (Interleukin 8)IBA
01/2016 - 12/2008
2Dopamine Receptors (Dopamine Receptor)IBA
11/2015 - 07/2013
2Superoxides (Superoxide)IBA
05/2014 - 01/2012
2Interleukin-18 (Interleukin 18)IBA
08/2013 - 08/2012
2Carrier Proteins (Binding Protein)IBA
04/2013 - 05/2010
2ButyrylcholinesteraseIBA
03/2013 - 03/2013
2SmokeIBA
01/2012 - 01/2002
2Monoamine Oxidase (MAO)IBA
09/2009 - 01/2003
2Methylphenidate (Ritalin)FDA LinkGeneric
01/2009 - 04/2002
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2008 - 12/2008
2ProgesteroneFDA LinkGeneric
10/2007 - 08/2004
2Bupropion (Wellbutrin)FDA LinkGeneric
02/2006 - 07/2002
2tiagabine (Gabitril)FDA Link
11/2005 - 11/2003
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2004 - 08/2003
2Desipramine (Pertofrane)FDA LinkGeneric
08/2003 - 01/2002
1Nerve Growth Factors (Neurotrophins)IBA
01/2016
1pramipexol (pramipexole)FDA LinkGeneric
11/2015
1kappa Opioid Receptors (kappa Opioid Receptor)IBA
08/2015
1Carbidopa (Lodosyn)FDA LinkGeneric
07/2014
1Levodopa (L Dopa)FDA LinkGeneric
07/2014
1Cholera ToxinIBA
07/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2014
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
05/2014
1Free RadicalsIBA
10/2013
1Guanfacine (Tenex)FDA LinkGeneric
10/2013
1OxygenIBA
10/2013
1Vitamin EFDA LinkGeneric
10/2013
1AntioxidantsIBA
10/2013
1EnzymesIBA
08/2013
1Phosphotransferases (Kinase)IBA
07/2013
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
06/2013
1Insulin-Like Growth Factor II (Somatomedin A)IBA
04/2013
1Messenger RNA (mRNA)IBA
04/2013
1ThioredoxinsIBA
02/2013
1CopperIBA
02/2013
1Valine (L-Valine)FDA Link
10/2012
1Methionine (L-Methionine)FDA Link
10/2012
1valylvaline (Val-Val)IBA
10/2012
1Ginkgo biloba extract 761 (Rokan)IBA
10/2012
1Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
09/2012
1tropisetron (Navoban)IBA
09/2012
1Street Drugs (Illicit Drugs)IBA
07/2012
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
06/2012
1Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2012
1Haloperidol (Haldol)FDA LinkGeneric
04/2012
1Doxazosin (Cardura)FDA LinkGeneric
01/2012
1Genetic Markers (Genetic Marker)IBA
02/2011
1tetrahydropalmatineIBA
01/2011
1CalciumIBA
05/2010
1Biological Markers (Surrogate Marker)IBA
12/2009
1aripiprazole (Abilify)FDA Link
07/2009
1Hydrocortisone (Cortisol)FDA LinkGeneric
05/2009
1Adrenocorticotropic Hormone (ACTH)FDA Link
05/2009
1AntibodiesIBA
04/2009

Therapy/Procedure

18Drug Therapy (Chemotherapy)
09/2014 - 04/2004
5Immunotherapy
11/2014 - 02/2004